Proteomic Differences in Blood Plasma Associated with Antidepressant Treatment Response

Turck, Christoph W.; Guest, Paul C.; Maccarrone, Giuseppina; Ising, Marcus; Kloiber, Stefan; Lucae, Susanne; Holsboer, Florian; Martins-de-Souza, Daniel

doi:10.3389/fnmol.2017.00272

Cited by 18 publications

(10 citation statements)

References 33 publications

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“…Further, elevated proteoforms of hemopexin have been found in farmers with musculoskeletal disorder 35 . In addition, several proteomic studies of major depressive disorder have been conducted, revealing proteins to be involved in similar processes presented in this study, mainly acute-phase, blood coagulation, and immunity [51][52][53] . These studies indicate that the immune system and its proteins might be affected by elevated depression.…”

Section: Discussionmentioning

confidence: 64%

Significant correlation between plasma proteome profile and pain intensity, sensitivity, and psychological distress in women with fibromyalgia

Wåhlén

Ernberg

Mannerkorpi

et al. 2020

Sci Rep

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Fibromyalgia (FM) is a complex pain condition where the pathophysiological and molecular mechanisms are not fully elucidated. The primary aim of this study was to investigate the plasma proteome profile in women with FM compared to controls. The secondary aim was to investigate if plasma protein patterns correlate with the clinical variables pain intensity, sensitivity, and psychological distress. Clinical variables/background data were retrieved through questionnaires. Pressure pain thresholds (PPT) were assessed using an algometer. The plasma proteome profile of FM (n = 30) and controls (n = 32) was analyzed using two-dimensional gel electrophoresis and mass spectrometry. Quantified proteins were analyzed regarding group differences, and correlations to clinical parameters in FM, using multivariate statistics. Clear significant differences between FM and controls were found in proteins involved in inflammatory, metabolic, and immunity processes. Pain intensity, PPT, and psychological distress in FM had associations with specific plasma proteins involved in blood coagulation, metabolic, inflammation and immunity processes. This study further confirms that systemic differences in protein expression exist in women with FM compared to controls and that altered levels of specific plasma proteins are associated with different clinical parameters.

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Section: Discussionmentioning

confidence: 64%

Significant correlation between plasma proteome profile and pain intensity, sensitivity, and psychological distress in women with fibromyalgia

Wåhlén

Ernberg

Mannerkorpi

et al. 2020

Sci Rep

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“…Turck et al [41] showed that differences in the levels of 29 proteins at baseline were found in the group with a favorable treatment response, where most of these proteins were components of metabolism or immune response pathways as well as multiple components of the coagulation cascade. After the treatment period, 2 proteins that were altered in responders and 9 in nonresponders overlapped with those proteins that had been identified in the baseline group [41]. Of this, the fibrinogen alpha chain was 1 of the 9 altered proteins in nonresponders as shown by our group [42].…”

Section: Clinical Studiesmentioning

confidence: 99%

Molecular Mechanisms Associated with Antidepressant Treatment on Major Depression

et al. 2021

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Major depressive disorder (MDD) is a complex and multifactorial psychiatric disorder that causes serious health, social, and economic concerns worldwide. The main treatment of the symptoms is through antidepressant (AD) drugs. However, not all patients respond properly to these drugs. Omic sciences are widely used to analyze not only biomarkers for the AD response but also their molecular mechanism. In this review, we aimed to focus on omics data to better understand the molecular mechanisms involving AD effects on MDD. We consistently found, from preclinical to clinical data, that glutamatergic transmission, immune/inflammatory processes, energy metabolism, oxidative stress, and lipid metabolism were associated with traditional and potential new ADs. Despite efforts of studies investigating biomarkers of response to ADs, which could contribute to personalized treatment, there is no biomarker panel available for clinical application. From clinical genomic studies, we found that the main findings contribute to the development of pharmacogenomic tests for AD efficacy for each patient. Several studies pointed at DRD2, PXDNL, CACNA1E, and CACNA2D1 genes as potential targets for MDD treatment and the efficacy and rapid-antidepressant effect of ketamine. Finally, more in-depth studies of the molecular targets pointed here are needed to determine the clinical relevance and provide further evidence for precision MDD treatment.

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“…However, some plasma biomolecules have been reported as potential biomarkers for MDD. For example, apolipoprotein D and ceruloplasmin have been reported to be associated with changes in lipid metabolism and immunoregulation in MDD patients [ 1 , 2 , 3 ]. The concentrations of lipids such as carnitine C10:1 and PE-O 36:5 were shown to be downregulated, while the concentration of LPE 18:1 sn-2 appeared upregulated in MDD patients [ 4 ].…”

Section: Introductionmentioning

confidence: 99%

Characterization of Potential Protein Biomarkers for Major Depressive Disorder Using Matrix-Assisted Laser Desorption Ionization/Time-of-Flight Mass Spectrometry

Lin

Hung

et al. 2021

Molecules

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Matrix-assisted laser desorption ionization/time-of-flight (MALDI-TOF) mass spectrometry is a sensitive analytical tool for characterizing various biomolecules in biofluids. In this study, MALDI-TOF was used to characterize potential plasma biomarkers for distinguishing patients with major depressive disorder (MDD) from patients with schizophrenia and healthy controls. To avoid interference from albumin—the predominant protein in plasma—the plasma samples were pretreated using acid hydrolysis. The results obtained by MALDI-TOF were also validated by electrospray ionization-quadrupole time-of-flight (ESI-QTOF) mass spectrometry. The analytical results were further treated with principal component analysis (PCA), hierarchical clustering analysis (HCA), and receiver operating characteristic (ROC) curve analysis. The statistical analyses showed that MDD patients could be distinguished from schizophrenia patients and healthy controls by the lack of apolipoprotein C1 (Apo C1), which, in fact, was detected in healthy controls and schizophrenia patients. This protein is suggested to be a potential plasma biomarker for distinguishing MDD patients from healthy controls and schizophrenia patients. Since sample preparation for MALDI-TOF is very simple, high-throughput plasma apolipoprotein analysis for clinical purposes is feasible.

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Proteomic Differences in Blood Plasma Associated with Antidepressant Treatment Response

Cited by 18 publications

References 33 publications

Significant correlation between plasma proteome profile and pain intensity, sensitivity, and psychological distress in women with fibromyalgia

Significant correlation between plasma proteome profile and pain intensity, sensitivity, and psychological distress in women with fibromyalgia

Molecular Mechanisms Associated with Antidepressant Treatment on Major Depression

Characterization of Potential Protein Biomarkers for Major Depressive Disorder Using Matrix-Assisted Laser Desorption Ionization/Time-of-Flight Mass Spectrometry

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