Proteomic identification of neurotrophins in the eutopic endometrium of women with endometriosis

Browne, Aimee S.; Yu, Jie; Huang, Ruo‐Pan; Francisco, A.M.C.; Sidell, Neil; Taylor, Robert N.

doi:10.1016/j.fertnstert.2012.05.027

Cited by 70 publications

(49 citation statements)

References 37 publications

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“…[80][81][82][83] This is particularly critical for the understanding of endometriosis-associated infertility. It is now becoming clear that the eutopic endometrium of women with endometriosis is different to that of women without endometriosis.…”

Section: Altered Eutopic Endometrium In Women With Endometriosismentioning

confidence: 99%

Natural Killer Cells: Key Players in Endometriosis

Thiruchelvam

Wingfield

O’Farrelly

2015

American J Rep Immunol

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Endometriosis affects more than 10% of women, causing significant pain and morbidity. It is also a significant cause of infertility. The aetiology of the disease remains an enigma, and the mechanisms responsible for the associated infertility are unclear. A role for immune cells in endometriosis has been postulated, with attention directed towards natural killer (NK) cells and macrophages. NK cells kill tumours and infected cells but also have roles in tissue remodelling in several organs including the uterus and are key to successful pregnancy. Here, we explore evidence (from peer-reviewed published articles) of phenotypic and functional abnormalities in NK cell subpopulations of women with endometriosis. It is clear that peripheral blood NK cells and peritoneal NK cells have reduced cytotoxic function in women with endometriosis. Uterine NK cells have a vital role in infertility, but very little research has been carried out in this area. We propose that abnormal u NK cell activity may contribute to the pathogenesis of endometriosis and its associated infertility and that future research should focus on this complex area.

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Section: Altered Eutopic Endometrium In Women With Endometriosismentioning

confidence: 99%

Natural Killer Cells: Key Players in Endometriosis

Thiruchelvam

Wingfield

O’Farrelly

2015

American J Rep Immunol

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“…Recent proteomic studies showed that levels of NT-4/5 and BDNF in biopsies from endometriosis cases are greater than in controls, whereas nerve growth factor levels are similar. These results suggest that alterations in levels of NT-4/5 and BDNF may stimulate differential nerve fiber growth and contribute to the pain associated with endometriosis (Browne et al, 2012; Kobayashi et al, 2014). Neurotrophins are also implicated in the development of innervation of ectopic endometrial lesions.…”

Section: Molecular Mechanisms Of Reproductive Tract Neuroplasticitymentioning

confidence: 84%

Estrogen and female reproductive tract innervation: Cellular and molecular mechanisms of autonomic neuroplasticity

Brauer

Smith

2015

Autonomic Neuroscience

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The female reproductive tract undergoes remarkable functional and structural changes associated with cycling, conception and pregnancy, and it is likely advantageous to both individual and species to alter relationships between reproductive tissues and innervation. For several decades, it has been appreciated that the mammalian uterus undergoes massive sympathetic axon depletion in late pregnancy, possibly representing an adaptation to promote smooth muscle quiescence and sustained blood flow. Innervation to other structures such as cervix and vagina also undergo pregnancy-related changes in innervation that may facilitate parturition. These tissues provide highly tractable models for examining cellular and molecular mechanisms underlying peripheral nervous system plasticity. Studies show that estrogen elicits rapid degeneration of sympathetic terminal axons in myometrium, which regenerate under low-estrogen conditions. Degeneration is mediated by the target tissue: under estrogen's influence, the myometrium produces proteins repulsive to sympathetic axons including BDNF, neurotrimin, semaphorins, and pro-NGF, and extracellular matrix components are remodeled. Interestingly, nerve depletion does not involve diminished levels of classical sympathetic neurotrophins that promote axon growth. Estrogen also affects sympathetic neuron neurotrophin receptor expression in ways that appear to favor pro-degenerative effects of the target tissue. In contrast to the uterus, estrogen depletes vaginal autonomic and nociceptive axons, with the latter driven in part by estrogen-induced suppression BMP4 synthesis. These findings illustrate that hormonally mediated physiological plasticity is a highly complex phenomenon involving multiple, predominantly repulsive target-derived factors acting in concert to achieve rapid and selective reductions in innervation.

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“…Thus, the expression of NGF and its receptor TrkA and p75 [38], as well as the expression BNDF and NT-4 were significantly increased [39].…”

Section: Neurogenesis In the Endometriummentioning

confidence: 92%

Innovative approach in assessing the role of neurogenesis, angiogenesis, and lymphangiogenesis in the pathogenesis of external genital endometriosis

Sheveleva¹,

Bejenar

Комличенко

et al. 2016

Gynecological Endocrinology

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Endometriosis is a chronic, progressive, relapsing estrogen-dependent disorder characterized by the growth of tissue structure and function similar to the endometrium outside the normal mucosa of the uterine cavity localization. Endometriosis is found in 10-15% of women in reproductive age and it is one of the main causes of pelvic pain syndrome and infertility. Mechanisms of the development of endometriosis and related pathological pain impulses are still poorly understood and therapeutic approaches do not always have a sufficient effect; in this connection, the study of the pathogenesis of endometriosis and endometriosis-associated pain currently is perspective. Identification of significant factors of angiogenesis, lymphangiogenesis, and neurogenesis in the external genital endometriosis will promote the development of non-invasive early diagnosis and pathogenetic therapy.

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Proteomic identification of neurotrophins in the eutopic endometrium of women with endometriosis

Cited by 70 publications

References 37 publications

Natural Killer Cells: Key Players in Endometriosis

Natural Killer Cells: Key Players in Endometriosis

Estrogen and female reproductive tract innervation: Cellular and molecular mechanisms of autonomic neuroplasticity

Innovative approach in assessing the role of neurogenesis, angiogenesis, and lymphangiogenesis in the pathogenesis of external genital endometriosis

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