Proteomic insights into modifiable risk of venous thromboembolism and cardiovascular comorbidities

Yuan, Shuai; Xu, Fengzhe; Zhang, Han; Chen, Jie; Ruan, Xixian; Li, Yuying; Burgess, Stephen; Åkesson, Agneta; Li, Xue; Gill, Dipender; Larsson, Susanna C.

doi:10.1016/j.jtha.2023.11.013

Journal of Thrombosis and Haemostasis

2024

DOI: 10.1016/j.jtha.2023.11.013

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Proteomic insights into modifiable risk of venous thromboembolism and cardiovascular comorbidities

Shuai Yuan,

Fengzhe Xu,

Han Zhang

et al.

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Cited by 7 publications

References 54 publications

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Sodium-glucose cotransporter protein 2 inhibition, plasma proteins, and ischemic stroke: A mediation Mendelian randomization and colocalization study

Chen,

Meng,

Guo

et al. 2025

Journal of Stroke and Cerebrovascular Diseases

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Sodium-glucose cotransporter protein 2 inhibition, plasma proteins, and ischemic stroke: A mediation Mendelian randomization and colocalization study

Chen,

Meng,

Guo

et al. 2025

Journal of Stroke and Cerebrovascular Diseases

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Hereditary Angioedema and Venous Thromboembolism: Where There's Smoke, There's Fire

Grover

2024

Semin Thromb Hemost

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C1-inhibitor deficiency–associated hereditary angioedema (C1INH-HAE) is a rare congenital swelling disorder caused by mutations in the SERPING1 gene. Despite evidence of a systemic procoagulant state in C1INH-HAE, dogma held that this disorder was not associated with thrombotic pathologies. Recent population scale epidemiological evidence has directly challenged this, with C1INH-HAE being associated with a significantly increased risk of venous thromboembolism (VTE). This review considers the growing body of evidence supporting associations between HAE and both a systemic procoagulant state and an increased risk of VTE. In the setting of C1INH-HAE, the relationship between the observed procoagulant and thrombotic phenotypes is a prime example of “where there's smoke, there's fire.” This review also discusses the impact of C1INH-HAE disease modifying therapies on coagulation and VTE. Further, the utility of preclinical mouse models of C1-inhibitor deficiency is considered.

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Venous thromboembolism: diagnostic advances and unaddressed challenges in management

Mathews,

Hinds,

Nguyen

2024

Current Opinion in Hematology

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Purpose of review This review summarizes recent advances in developing targeted diagnostics for venous thromboembolism (VTE) and unaddressed knowledge gaps in patient management. Without addressing these critical data needs, the morbidity in VTE patients will persist. Recent findings Recent studies investigating plasma protein profiles in VTE patients have identified key diagnostic targets to address the currently unmet need for low-cost, confirmatory, point-of-care VTE diagnostics. These studies and a growing body of evidence from animal model studies have revealed the importance of inflammatory and vascular pathology in driving VTE, which are currently unaddressed targets for VTE therapy. To enhance the translation of preclinical animal studies, clinical quantification of thrombus burden and comparative component analyses between modeled VTE and clinical VTE are necessary. Summary Lead candidates from protein profiling of VTE patients’ plasma offer a promising outlook in developing low cost, confirmatory, point-of-care testing for VTE. Additionally, addressing the critical knowledge gap of quantitatively measuring clinical thrombi will allow for an array of benefits in VTE management and informing the translatability of experimental therapeutics.

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Proteomic insights into modifiable risk of venous thromboembolism and cardiovascular comorbidities

Cited by 7 publications

References 54 publications

Sodium-glucose cotransporter protein 2 inhibition, plasma proteins, and ischemic stroke: A mediation Mendelian randomization and colocalization study

Sodium-glucose cotransporter protein 2 inhibition, plasma proteins, and ischemic stroke: A mediation Mendelian randomization and colocalization study

Hereditary Angioedema and Venous Thromboembolism: Where There's Smoke, There's Fire

Venous thromboembolism: diagnostic advances and unaddressed challenges in management

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