2021
DOI: 10.3389/fmolb.2021.730473
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Proteomic Insights Into Susceptibility and Resistance to Chronic-Stress-Induced Depression or Anxiety in the Rat Striatum

Abstract: Chronic stress is a key factor for the onset of anxiety and depression disorders. However, the stress-induced common and unique molecular basis of the two psychiatric disorders is not fully known and still needs to be explored. Previously, we employed a chronic mild stress (CMS) procedure to induce a rat model including depression-susceptible (Dep-Sus), anxiety-susceptible (Anx-Sus), and insusceptible (Insus) cohorts. In this work, we continuously analyze the striatal proteomes of the three stressed cohorts by… Show more

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Cited by 6 publications
(1 citation statement)
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“…In the top 10 DMP genes (Table 2 , brain-blood correlated CpG sites were highlighted in bold), ACIN1 (Fig. 2F ) was associated with chronic stress [ 30 ], SCRT1 (Fig. 2G ) involved the conversion of microglia to neuron [ 31 ] and the nerve system development [ 32 ], C11orf80 (Fig.…”
Section: Resultsmentioning
confidence: 99%
“…In the top 10 DMP genes (Table 2 , brain-blood correlated CpG sites were highlighted in bold), ACIN1 (Fig. 2F ) was associated with chronic stress [ 30 ], SCRT1 (Fig. 2G ) involved the conversion of microglia to neuron [ 31 ] and the nerve system development [ 32 ], C11orf80 (Fig.…”
Section: Resultsmentioning
confidence: 99%