Proteomic profile changes associated with diminished expression of T-cell intracellular antigens reveal a hormesis response

Alcalde, José; Izquierdo, José M.

doi:10.1016/j.bbrc.2018.07.017

Cited by 3 publications

(2 citation statements)

References 41 publications

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“…Hormesis is a process whereby exposure to a toxin induces increased resistance to its toxic effects, 30 , 31 and it is known to occur in various types of cells in the blood. 32–34 Hormesis is most accepted as a consequence of low-dose radiation exposure in the field of health physics, 35 but there is evidence from many other fields. 31 Indeed, since oil well fires are an accepted element in the risk profile of GWI incidence, 36 it is reasonable to conjecture that this exposure is responsible for induction of NER, since it is necessary for the repair of so-called “bulky DNA adducts” associated with reaction with the products of organic combustion.…”

Section: Discussionmentioning

confidence: 99%

Preliminary Evidence for a Hormetic Effect on DNA Nucleotide Excision Repair in Veterans with Gulf War Illness

et al. 2019

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Abstract Introduction Veterans of the 1991 Gulf War were potentially exposed to a mixture of stress, chemicals and radiation that may have contributed to the persistent symptoms of Gulf War Illness (GWI). The genotoxic effects of some of these exposures are mediated by the DNA nucleotide excision repair (NER) pathway. We hypothesized that individuals with relatively low DNA repair capacity would suffer greater damage from cumulative genotoxic exposures, some of which would persist, causing ongoing problems. Materials and Methods Blood samples were obtained from symptomatic Gulf War veterans and age-matched controls. The unscheduled DNA synthesis assay, a functional measurement of NER capacity, was performed on cultured lymphocytes, and lymphocyte mRNA was extracted and analyzed by sequencing. Results Despite our hypothesis that GWI would be associated with DNA repair deficiency, NER capacity in lymphocytes from affected GWI veterans actually exhibited a significantly elevated level of DNA repair (p = 0.016). Both total gene expression and NER gene expression successfully differentiated individuals with GWI from unaffected controls. The observed functional increase in DNA repair capacity was accompanied by an overexpression of genes in the NER pathway, as determined by RNA sequencing analysis. Conclusion We suggest that the observed elevations in DNA repair capacity and NER gene expression are indicative of a “hormetic,” i.e., induced or adaptive protective response to battlefield exposures. Normally such effects are short-term, but in these individuals this response has resulted in a long-term metabolic shift that may also be responsible for the persistent symptoms of GWI.

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Section: Discussionmentioning

confidence: 99%

Preliminary Evidence for a Hormetic Effect on DNA Nucleotide Excision Repair in Veterans with Gulf War Illness

et al. 2019

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“…Proteomic expression profiling is a powerful tool for comprehensively understanding physiological and pathological processes of organisms at the protein level (Alcalde & Izquierdo, 2018). DEPs between Groups 1 and Groups 2 are useful for exploring the molecular mechanism of L-lactic acid production in B. coagulans BCS13002 with distinct carbon sources.…”

Section: Proteomic Identification Of Differentially Expressed Proteins Between Groups 1 and Groupsmentioning

confidence: 99%

Gelatinised and hydrolysed corn starch is a cost‐effective carbon source with higher production of L‐lactic acid by Bacillus coagulans compared with glucose

Yao

Liu

Brennan

2020

Int J of Food Sci Tech

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L-lactic acid is an important organic acid widely used in pharmaceutical, food and textile industries. Bacillus coagulans BCS13002 can efficiently produce L-lactic acid with two kinds of carbon sources. BCS13002 produced L-lactic acid at a content of 10.23 AE 0.16 g/L and 11.67 AE 0.22 g/L, when glucose and gelatinised and hydrolysed corn starch (GHCS) were used, respectively. GHCS exhibits several advantages, including high yield of L-lactic acid and low cost. Proteomics analyses identified several key enzymes, which contributed to the higher production of L-lactic acid when GHCS was used as the carbon source. Those key enzymes were involved in the two-component system (SpoOF), pantothenate and CoA biosynthesis (pantothenate synthetase, 1.584-fold; dihydroxy-acid dehydratase, 1.517-fold), beta-alanine metabolism (1.605-fold) and valine, leucine and isoleucine biosynthesis (1.517-fold) pathways. This study provides a biological basis for using GHCS as a substitute of glucose in the production of L-lactic acid.

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TIAR and FMRP shape pro-survival nascent proteome of leukemia cells in the bone marrow microenvironment

Wolczyk¹,

Serwa²,

Kominek³

et al. 2023

iScience

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Proteomic profile changes associated with diminished expression of T-cell intracellular antigens reveal a hormesis response

Cited by 3 publications

References 41 publications

Preliminary Evidence for a Hormetic Effect on DNA Nucleotide Excision Repair in Veterans with Gulf War Illness

Preliminary Evidence for a Hormetic Effect on DNA Nucleotide Excision Repair in Veterans with Gulf War Illness

Gelatinised and hydrolysed corn starch is a cost‐effective carbon source with higher production of L‐lactic acid by Bacillus coagulans compared with glucose

TIAR and FMRP shape pro-survival nascent proteome of leukemia cells in the bone marrow microenvironment

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