Proteomic profile of preeclampsia in the first trimester of pregnancy

Jacobo‐Baca, Guillermo; Salazar-Ybarra, Rodolfo Amador; Cruz, Víctor Manuel Torres de la; Guzmán-López, Santos; Elizondo‐Omaña, Rodrigo Enrique; Guzmán-López, Abel; Vázquez-Barragán, Miguel Ángel; Martínez-de-Villarreal, Laura Elia

doi:10.1080/14767058.2020.1820980

Cited by 7 publications

(6 citation statements)

References 41 publications

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“…CE has been found to interfere decidualization during embryo implantation, 10 raising the concern that pre‐existing CE may exert negative impact on normal placentation, resulting in the development of placenta‐mediated pregnancy complications subsequently 22,23 . Our results demonstrated that the prevalence rates of pregnancy induced hypertension and preeclampsia were comparable between patients with CCE and NCE (6.1% vs. 8.0% and 1.0% vs.0.6%).…”

Section: Discussionmentioning

confidence: 55%

“…CE has been found to interfere decidualization during embryo implantation, 10 raising the concern that pre-existing CE may exert negative impact on normal placentation, resulting in the development of placenta-mediated pregnancy complications subsequently. 22,23 Our results demonstrated that the prevalence rates of pregnancy induced hypertension and preeclampsia were comparable between patients with CCE and NCE (6.1% vs. 8.0% and 1.0% vs.0.6%). Likewise, there were no significant differences between the groups of CCE and NCE on the rates of other placenta-derived complications, including placental previa, placenta abruption, low birthweight, and fetal death in late pregnancy.…”

Section: 1%)mentioning

confidence: 53%

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Impact of antibiotic cured chronic endometritis on perinatal outcomes: Re‐evaluation of a cohort study with a detailed follow‐up

Zhang

Yang

Xiong

et al. 2023

American J Rep Immunol

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Problem The impact of antibiotic‐cured chronic endometritis (CE) on perinatal outcomes of patients conceived with frozen embryo transfer (FET) was unclear. Method This study was to re‐evaluate the perinatal outcomes of a cohort of infertile patients who had undergone endometrial biopsy for CE detection from February 2018 to December 2019 and successfully delivered babies after FET. The study population was divided into two groups: the non‐CE (NCE) group (0‐4/HPF CD138) and the cured‐CE (CCE) group (CD138+/HPF≥5 and has been cured after one or two rounds of antibiotic treatment). For subgroup analysis, the NCE group was further divided into subgroup 1 (CD138+/HPF = 0), subgroup 2 (CD138+/HPF = 1‐4 with antibiotic treatment), and subgroup 3 (CD138+/HPF = 1‐4 without antibiotic treatment) Results A total of 321 live births, including 210 in the NCE group and 111 in the CCE group were analyzed. The prevalence rates of premature rupture of the membrane and preterm birth were comparable between NCE and CCE (6.2% vs. 7.1% and 10.8% vs. 10.1%, respectively) groups. In addition, no differences were detected in the rates of placenta‐mediated complications, such as preeclampsia, placenta abruption, or low birthweight. Multiple logistic analyses confirmed that CCE was not associated with an increased risk of any adverse perinatal outcomes. Subgroup analysis in NCE failed to find any significant differences in the incidences of obstetrical and neonatal complications. Conclusions CCE might not increase the risks of adverse perinatal outcomes after antibiotic treatment.

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Section: Discussionmentioning

confidence: 55%

Section: 1%)mentioning

confidence: 53%

Impact of antibiotic cured chronic endometritis on perinatal outcomes: Re‐evaluation of a cohort study with a detailed follow‐up

Zhang

Yang

Xiong

et al. 2023

American J Rep Immunol

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“…Previous studies reported upregulated expression of RBM25 in plasma samples of preeclampsia (PE) patients. 15 In order to investigate the expression and function of RBM25 in placental tissues of PE pregnant women, we collected placental tissues of normal and PE pregnant women, respectively. First, hematoxylin and eosin (HE) staining was used to identify these tissues (Figure 1(A)).…”

Section: Resultsmentioning

confidence: 99%

“…A recent study found that RBM25 is involved in cellular EMT processes and tumor cell migration by binding and promoting circAMOTL1L biogenesis. 14 Fascinatingly, Jacobo-Baca et al 15 used proteomic profile to find a significant increase in RBM25 expression in serum of PE pregnant women. However, the expression and function of RBM25 in PE placental are unclear.…”

Section: Introductionmentioning

confidence: 99%

RBM25 induces trophoblast epithelial-mesenchymal transition and preeclampsia disorder by enhancing the positive feedback loop between Grhl2 and RBM25

Zhang,

Chen,

Yang

et al. 2023

Exp Biol Med (Maywood)

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Defects in migration and invasion caused by dysregulation of trophoblast epithelial-mesenchymal transformation (EMT) are one of the key factors in the pathogenesis of preeclampsia (PE). RNA-binding motif protein 25 (RBM25) is an RNA-binding protein involved in a variety of cellular processes, including cell proliferation, apoptosis, cell migration and invasion, and EMT. However, the expression and function of RBM25 in placental of PE remain unclear. In this study, we reveal that the expression of RBM25 is significantly elevated in PE placental tissue. RBM25 depletion and over-expression in trophoblast cells increase and decrease, respectively, cell migration and invasion by regulating EMT marker E-cadherin and Vimentin expression. Mechanistically, Grhl2 is involved in RBM25-regulated trophoblast cell migration, invasion, and EMT through RBM25-facilitated mRNA stabilization. Furthermore, the upregulation of Grhl2 enhances the expression of RBM25 through transcription and forms a positive feedback regulation in the progression of PE. These findings suggest that upregulation of RBM25 induces dysregulation of trophoblast EMT by enhancing positive feedback regulation of Grhl2 and RBM25, leading to defects in cell migration and invasion. Targeting this newly identified regulatory axis may provide benefits in the prevention and treatment of PE.

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“…In addition, alternative splicing of PRRC2C was suggested to be related with lung adenocarcinoma (7); and mutation of PRRC2C was reported to be associated with Endemic Burkitt lymphoma (8). The expression of PRRC2C protein showed a tendency to be present in Serum of preeclampsia patients (9). The similar chromosome region has been reported to have frequent amplification in HCC (10), however the involvement and function of PRRC2C have not been explored in HCC.…”

Section: Introductionmentioning

confidence: 99%

Silencing proline-rich coiled-coil 2C inhibit the proliferation and metastasis of liver cancer cells

Zhang¹,

Xu²,

Chen³

2023

J Gastrointest Oncol

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Proteomic profile of preeclampsia in the first trimester of pregnancy

Cited by 7 publications

References 41 publications

Impact of antibiotic cured chronic endometritis on perinatal outcomes: Re‐evaluation of a cohort study with a detailed follow‐up

Impact of antibiotic cured chronic endometritis on perinatal outcomes: Re‐evaluation of a cohort study with a detailed follow‐up

RBM25 induces trophoblast epithelial-mesenchymal transition and preeclampsia disorder by enhancing the positive feedback loop between Grhl2 and RBM25

Silencing proline-rich coiled-coil 2C inhibit the proliferation and metastasis of liver cancer cells

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