2019
DOI: 10.1038/s41598-019-45473-9
|View full text |Cite
|
Sign up to set email alerts
|

Proteomic profiling of extracellular vesicles reveals additional diagnostic biomarkers for myocardial infarction compared to plasma alone

Abstract: Extracellular vesicles (EVs) are submicron, membrane-enclosed particles that are released from cells in various pathophysiological states. The molecular cargo of these vesicles is considered to reflect the composition of the cell of origin, and the EV proteome is therefore a potential source of biomarkers for various diseases. Our aim was to determine whether EVs isolated from plasma provide additional diagnostic value or improved pathophysiological understanding compared to plasma alone in the context of myoc… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1
1

Citation Types

5
50
0

Year Published

2020
2020
2023
2023

Publication Types

Select...
9
1

Relationship

1
9

Authors

Journals

citations
Cited by 56 publications
(55 citation statements)
references
References 40 publications
5
50
0
Order By: Relevance
“…Our results indicated that EVs contained more proteins that were significantly different compared to that from plasma. Similar observations were made by Gidlöf et al [ 43 ], who compared plasma and EVs from patients with myocardial infarction to controls using PEA. EVs provided additional information that could not have been obtained with plasma alone [ 43 ].…”
Section: Discussionsupporting
confidence: 85%
“…Our results indicated that EVs contained more proteins that were significantly different compared to that from plasma. Similar observations were made by Gidlöf et al [ 43 ], who compared plasma and EVs from patients with myocardial infarction to controls using PEA. EVs provided additional information that could not have been obtained with plasma alone [ 43 ].…”
Section: Discussionsupporting
confidence: 85%
“…Findings further support the potential benefits of such treatment. As IL-6 is also a marker with myocardial infarction and smoking, treatment efficacy may be modulated by active cigarette smoking or preexisting cardiovascular disease targeting related disease complications 25,27 .…”
Section: Resultsmentioning
confidence: 99%
“…Various pathways within the cell influence EV composition and may generate additional EV subpopulations. Furthermore, the EV membrane and cargo seem to differ based on the originating cell type [33]. EV research is not very transparent, with many publications from different research areas.…”
Section: Heterogeneity Of Extracellular Vesicles (Evs)mentioning
confidence: 99%