Proteomic profiling of membrane vesicles from Mycobacterium avium subsp. paratuberculosis: Navigating towards an in silico design of a multi-epitope vaccine targeting membrane vesicle proteins

Lee, Jen-Jie; Abdullah, Mohd; Liu, Jinjing; Carvalho, Isabel Azevedo; Junior, Abelardo Silva; Moreira, Maria Aparecida Scatamburlo; Mohammed, Hussni; DeLisa, Matthew P.; McDonough, Sean P.; Chang, Yung-Fu

doi:10.1016/j.jprot.2023.105058

Journal of Proteomics

2024

DOI: 10.1016/j.jprot.2023.105058

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Proteomic profiling of membrane vesicles from Mycobacterium avium subsp. paratuberculosis: Navigating towards an in silico design of a multi-epitope vaccine targeting membrane vesicle proteins

Jen-Jie Lee,

Mohd Abdullah,

Jinjing Liu

et al.

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Bacterial membrane vesicles in the pathogenesis and treatment of inflammatory bowel disease

Olovo,

Wiredu Ocansey,

et al. 2024

Gut Microbes

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Inflammatory bowel disease (IBD) is a chronic and debilitating condition of relapsing and remitting inflammation in the gastrointestinal tract. Conventional therapeutic approaches for IBD have shown limited efficacy and detrimental side effects, leading to the quest for novel and effective treatment options for the disease. Bacterial membrane vesicles (MVs) are nanosized lipid particles secreted by lysis or blebbing processes from both Gram-negative and Gram-positive bacteria. These vesicles, known to carry bioactive components, are facsimiles of the parent bacterium and have been implicated in the onset and progression, as well as in the amelioration of IBD. This review discusses the overview of MVs and their impact in the pathogenesis, diagnosis, and treatment of IBD. We further discuss the technical challenges facing this research area and possible research questions addressing these challenges. We summarize recent advances in the diverse relationship between IBD and MVs, and the application of this knowledge as a viable and potent therapeutic strategy for IBD.

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Bacterial membrane vesicles in the pathogenesis and treatment of inflammatory bowel disease

Olovo,

Wiredu Ocansey,

et al. 2024

Gut Microbes

View full text Add to dashboard Cite

show abstract

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Proteomic profiling of membrane vesicles from Mycobacterium avium subsp. paratuberculosis: Navigating towards an in silico design of a multi-epitope vaccine targeting membrane vesicle proteins

Cited by 1 publication

References 92 publications

Bacterial membrane vesicles in the pathogenesis and treatment of inflammatory bowel disease

Bacterial membrane vesicles in the pathogenesis and treatment of inflammatory bowel disease

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