2024
DOI: 10.1128/msystems.01335-24
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Proteomic profiling of the local and systemic immune response to pediatric respiratory viral infections

Emily Lydon,
Christina M. Osborne,
Brandie D. Wagner
et al.

Abstract: Viral lower respiratory tract infection (vLRTI) is a leading cause of hospitalization and death in children worldwide. Despite this, no studies have employed proteomics to characterize host immune responses to severe pediatric vLRTI in both the lower airway and systemic circulation. To address this gap, gain insights into vLRTI pathophysiology, and test a novel diagnostic approach, we assayed 1,305 proteins in tracheal aspirate (TA) and plasma from 62 critically ill children using SomaScan. We performed differ… Show more

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