Proteomics: a tool to develop novel diagnostic methods and unravel molecular mechanisms of pediatric diseases

Torres-Arroyo, Angélica; Ruiz-Lara, Arturo; Castillo-Villanueva, Adriana; Méndez-Cruz, Sara Teresa; Espinosa-Padilla, S; Espinosa-Rosales, Francisco; Zárate-Mondragón, Flora; Cervantes-Bustamante, Roberto; Bosch-Canto, Vanessa; Vizzuett-López, Iris; Ordaz-Fávila, Juan Carlos; Oria-Hernández, Jesús; Reyes‐Vivas, Horacio

doi:10.1016/j.bmhimx.2017.03.009

Cited by 1 publication

(2 citation statements)

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“…The same protein in different physiological states, different subcellular localization, different amino acid site modification, may correspond to different functions. 47 Ostareck-Lederer et al 48 showed that hnRNP K phosphorylation by c-Src reversibly impairs the binding between hnRNP K and the differentiation control element (DICE) of LOX mRNA, and activates the DICE-bearing mRNAs. For this phenomenon, Ostareck et al 49 explained the mechanism.…”

Section: Hnrnp K Involves In Posttranslational Modificationmentioning

confidence: 99%

“…Protein modification (PTM) is vital in the life process, which is closely related to gene expression, signaling pathway, cell division, and other processes. The same protein in different physiological states, different subcellular localization, different amino acid site modification, may correspond to different functions . Ostareck‐Lederer et al showed that hnRNP K phosphorylation by c‐Src reversibly impairs the binding between hnRNP K and the differentiation control element (DICE) of LOX mRNA, and activates the DICE‐bearing mRNAs.…”

Section: Hnrnp K Involves In Posttranslational Modificationmentioning

confidence: 99%

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Role of heterogeneous nuclear ribonucleoprotein K in tumor development

Chen

Zeng

Xiao

et al. 2019

J of Cellular Biochemistry

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Heterogeneous nuclear ribonucleoprotein K (hnRNP K) is an RNA/DNA special binding protein that participates in regulating the expression of related genes, transcription, RNA alternative splicing, translation, posttranslational modification, cell signal transduction, cell movement, interacts with ncRNAs, and induces angiogenesis. Moreover, several cellular functions forcefully indicated that hnRNP K participates in tumorigenesis. Numerous studies indicated hnRNP K is aberrantly elevated in multiple tumors. In addition, hnRNP K abnormal accumulation in cytoplasmic is also associated with poor prognosis. This suggests that hnRNP K may play a role in the development and progression of tumors. However, related studies demonstrated that hnRNP K acts as a tumor suppressor to suppress tumor formation. Therefore, this paper aims to explore the role of hnRNPK in tumors.

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Section: Hnrnp K Involves In Posttranslational Modificationmentioning

confidence: 99%

Section: Hnrnp K Involves In Posttranslational Modificationmentioning

confidence: 99%