Proteomics analysis of blood plasma in HIV-infected patients with chronic kidney disease

Lavinya, Amanda Anne; Lee, Cheng Siang; Hashim, Onn Haji; Azwa, Iskandar; Rajasuriar, Reena; Lim, Soo Kun; Wong, Yuen Fei

doi:10.1016/j.clinbiochem.2019.08.006

Cited by 5 publications

(4 citation statements)

References 36 publications

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“…Interestingly, premature aging and muscle tissue expression disorders were often detected in immunodeficiency mice, and MYH7 and TRIM63 gene expression disorders were also detected 42,43 . In addition, HP and ORM1 were related to immune response, and the expression was decreased in immunodeficiency virus (HIV) infected patients 44,45 . These evidences seem to suggest a link between muscle tissue disorders/immunodeficiency and ageing/cancer.…”

Section: Discussionmentioning

confidence: 99%

Transcriptomics analysis for the identification of potential age-related genes and cells associated with three major urogenital cancers

Cao

Yang

et al. 2021

Sci Rep

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Age is one of the most important risk factors of the occurrence for tumor patients. The majority of patients with urogenital cancers are the elderly, whose clinical characteristics are greatly affected by age and ageing. Our study aimed to explore age-related genes, cells, and biological changes in three common urogenital cancers via integrative bioinformatics analysis. First, mRNA (count format) and clinical data for bladder cancer, prostate cancer and renal cell carcinoma were downloaded from the Cancer Genome Atlas (TCGA). Through the comparison of clinicopathological characteristics, genes expression and cells infiltration between the old group and the young group, it was found that the clinical characteristics, genes and cells in the tumor microenvironment of different ages were quite different. And 4 key cells, 14 hub genes and some potential pathways were identified and considered as important factors. More importantly, we analyzed the differential landscape of the genes and cells from different perspectives, and confirmed its importance. In conclusion, we identified genes and cell types associated with age-related changes in the tumour microenvironment in urogenital cancer patients. These genes and cell types may play a critical role in the age-associated differences in clinicopathological characteristics among urogenital cancers, thus providing a link between ageing and cancer occurrence. The findings of this study may pave the way for the development of age-tailored approaches to treat cancer and other age-related diseases.

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Section: Discussionmentioning

confidence: 99%

Transcriptomics analysis for the identification of potential age-related genes and cells associated with three major urogenital cancers

Cao

Yang

et al. 2021

Sci Rep

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“…In addition, HP promoted Th1‐related reactions by preferentially inhibiting the release of Th2 cytokines (Arredouani et al, 2003). Moreover, HP was significantly elevated in HIV‐infected children with kidney dysfunction (Kooij et al, 2017; Lavinya et al, 2019). HP binds to CD4+ T cells, consuming them excessively.…”

Section: Discussionmentioning

confidence: 99%

Epidemiological investigation and proteomic profiling of typical TCM syndrome in HIV/AIDS immunological nonresponders

Zheng

et al. 2022

The Anatomical Record

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HIV/AIDS pandemic remains the world's most severe public health challenge, especially for HIV/AIDS immunological nonresponders (HIV/AIDS‐INRs), who tend to have higher mortality. Due to the advantages in promoting patients' immune reconstitution, Traditional Chinese medicine (TCM) has become one of the mainstays of complementary treatments for HIV/AIDS‐INRs. Given that effective TCM treatments largely depend on precise syndrome differentiation, there is an increasing interest in exploring biological evidence for the classification of TCM syndromes in HIV/AIDS‐INRs. In our study, to identify the typical HIV/AIDS‐INRs syndrome, an epidemiological survey was first conducted in the Liangshan prefecture (China), a high HIV/AIDS prevalence region. The key TCM syndrome, Yang deficiency of spleen and kidney (YDSK), was evaluated by using a tandem mass tag combined with liquid chromatography–tandem mass spectrometry (TMT‐LC–MS/MS). A total of 62 differentially expressed proteins (DEPs) of YDSK syndrome compared with healthy people were screened out. Comparative bioinformatics analyses showed that DEPs in YDSK syndrome were mainly associated with response to wounding and acute inflammatory response in the biological process. The pathway annotation is mainly enriched in complement and coagulation cascades. Finally, the YDSK syndrome‐specific DEPs such as HP and S100A9 were verified by ELISA, and confirmed as potential biomarkers for YDSK syndrome. Our study may lay the biological and scientific basis for the specificity of TCM syndromes in HIV/AIDs‐INRs, and may provide more opportunities for the deep understanding of TCM syndromes and the developing more effective and stable TCM treatment for HIV/AIDS‐INRs.

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“…Baseline RBP-4 levels in HIV-positive subjects were reported to be comparable with [ 48 ] or lower than those of HIV-negative controls [ 49 ]. However, RBP4 was significantly increased in HIV-infected patients with proteinuric chronic kidney disease [ 50 ], in those with overt associated lipodystrophy syndrome [ 51 ], and in those following treatment with highly active antiretroviral therapy [ 48 ]. Even in HIV/HCV-coinfected patients, levels of RBP-4 were higher for those with renal function impairment [ 52 ].…”

Section: Discussionmentioning

confidence: 99%

Altering retinol binding protein 4 levels in hepatitis C: Inflammation and steatosis matter

Chang

Chen

et al. 2020

Virulence

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Both hepatitis C virus (HCV) infection and retinol-binding protein 4 (RBP4) might contribute to insulin resistance (IR), how RBP4 links to IR in HCV infection remain elusive. A joint study of a prospective cohort of 842 chronically HCV-infected (CHC) patients (with 842 controls) and a line of HCV core transgenic mice was conducted. Of 842 patients, 771 had completed anti-HCV therapy and 667 had sustained virological responses (SVRs). Compared with controls, CHC patients had lower RBP4 levels. At baseline, age (95% CI β: −0.87~−0.317), BMI (0.516~2.036), triglycerides (0.03~0.127), neutrophil-to-lymphocyte ratio (NLR) (1.561~7.327), and estimated glomerular filtration rate (eGFR) (−0.342~−0.149) levels were associated with RBP4 levels in CHC patients. At 24-week post-therapy, male sex (0.652~8.129), BMI (0.199~1.254), triglycerides (0.039~0.088), uric acid (0.599~3.067), eGFR (−0.247 ~−0.14) levels, and fibrosis-4 (−3.602~−0.039) scores were associated with RBP4 levels in SVR patients; compared with baseline, except genotype 3 HCV-infected patients, SVR patients had increased RBP4 levels, which were comparable with controls, while no HOMA-IR index alteration was noted after SVR. The HCV core transgenic mice exhibited nonobese hepatic steatosis, had higher hepatic RBP4 expression, higher serum levels of RBP4 and triglycerides, but comparable HOMA-IR levels than non-transgenic littermates. In conclusion, steatosis, sex, age, uric acid, NLR, and FIB-4 levels were associated with HCV-related RBP4 levels; BMI, triglycerides, and eGFR levels were associated with non-HCV-related RBP4 levels. Reversal of low RBP4 levels after SVR was evident in non-genotype 3 HCV-infected patients. Steatosis and inflammation linked with metabolic alteration other than IR, determined RBP4 levels in HCV-infected patients.

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Proteomics analysis of blood plasma in HIV-infected patients with chronic kidney disease

Cited by 5 publications

References 36 publications

Transcriptomics analysis for the identification of potential age-related genes and cells associated with three major urogenital cancers

Transcriptomics analysis for the identification of potential age-related genes and cells associated with three major urogenital cancers

Epidemiological investigation and proteomic profiling of typical TCM syndrome in HIV/AIDS immunological nonresponders

Altering retinol binding protein 4 levels in hepatitis C: Inflammation and steatosis matter

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