Proteomics and Its Application in Pandemic Diseases

Thakur, Suman

doi:10.1021/acs.jproteome.0c00824

Cited by 3 publications

(4 citation statements)

References 42 publications

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“…Proteomics facilitates the deciphering of the knowledge related to structure–function relationships of protein targets. This information would provide novel insights into drug development to prevent infection and as well as to control transmission [ 141 ]. Several molecular docking, dynamics and pharmacology approaches have been investigated based on the binding affinity of drug components against COVID-19 [ [142] , [143] , [144] ].…”

Section: Possibilities Of Harnessing Omics Approaches To Combat Covid-19mentioning

confidence: 99%

Exploring peptide studies related to SARS-CoV to accelerate the development of novel therapeutic and prophylactic solutions against COVID-19

Madhavan¹,

Alomair²,

Ks³

et al. 2021

Journal of Infection and Public Health

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Recent advances in peptide research revolutionized therapeutic discoveries for various infectious diseases. In view of the ongoing threat of the COVID-19 pandemic, there is an urgent need to develop potential therapeutic options. Intense and accomplishing research is being carried out to develop broad-spectrum vaccines and treatment options for corona viruses, due to the risk of recurrent infection by the existing strains or pandemic outbreaks by new mutant strains. Developing a novel medicine is costly and time consuming, which increases the value of repurposing existing therapies. Since, SARS-CoV-2 shares significant genomic homology with SARS-CoV, we have summarized various peptides identified against SARS-CoV using in silico and molecular studies and also the peptides effective against SARS-CoV-2. Dissecting the molecular mechanisms underlying viral infection could yield fundamental insights in the discovery of new antiviral agents, targeting viral proteins or host factors. We postulate that these peptides can serve as effective components for therapeutic options against SARS-CoV-2, supporting clinical scientists globally in selectively identifying and testing the therapeutic and prophylactic agents for COVID-19 treatment. In addition, we also summarized the latest updates on peptide therapeutics against SARS-CoV-2.

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Section: Possibilities Of Harnessing Omics Approaches To Combat Covid-19mentioning

confidence: 99%

Exploring peptide studies related to SARS-CoV to accelerate the development of novel therapeutic and prophylactic solutions against COVID-19

Madhavan¹,

Alomair²,

Ks³

et al. 2021

Journal of Infection and Public Health

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“…COVID-19 is a highly infectious, airborne viral disease with a big threat for patients having respiratory, cardiovascular diseases, compromised immune systems, hypertension, diabetes and other diseases [ 1–3 ]. It was declared a global pandemic on 11 March 2020 by World Health Organization (WHO).…”

Section: Introductionmentioning

confidence: 99%

Diverse vaccine platforms safeguarding against SARS-CoV-2 and its variants

Chatterjee

Thakur

2022

Expert Review of Vaccines

Self Cite

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Introduction Appearances of SARS-CoV-2 variants have created havoc and additional challenges for the ongoing vaccination drive against pandemic COVID-19. Interestingly, several vaccine platforms are showing great potential to produce successful vaccines against SARS-CoV-2 and its variants. Billions of COVID-19 vaccine doses have been administered worldwide. Mix-and-Match COVID-19 vaccines involving the mixing of the same platform vaccines and also two different vaccine platforms may provide greater protection against SARS-CoV-2 and its variants. COVID-19 vaccines have become one of the most important tools to mitigate the ongoing pandemic COVID-19. Areas covered We describe SARS-Cov-2 variants, their impact on the population, COVID-19 vaccines, diverse vaccine platforms, doses of vaccines, the efficacy of vaccines against SARS-CoV-2 and its variants, mitigation of the COVID-19 transmission- alternatives to vaccines. Expert opinion Diverse vaccine platforms may safeguard against ongoing, deadly SARS-CoV-2 and its infectious variants. The efficacies of COVID-19 vaccines are significantly high after the administration of the second dose. Further, it protects individuals including vulnerable patients with co-morbidities from SARS-CoV-2 and its variants. The hospitalizations and deaths of the individuals may be prevented by COVID-19 vaccines.

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“…Additionally, the application of phosphoproteomics in pharmacodynamics and toxicity studies offers insights into how drugs modulate cellular signaling pathways. 25,49,[69][70][71] Phosphoproteomics provides a multidimensional perspective on the role of phosphoproteins in cellular processes. Monitoring changes in phosphoprotein profiles upon drug treatment can aid in assessing drug efficacy, predicting drug responses, and identifying potential toxicities; this information will consequently result in the development of safer and more efficient therapeutic strategies.…”

Section: Phosphoproteomicsmentioning

confidence: 99%

“…Monitoring changes in phosphoprotein profiles upon drug treatment can aid in assessing drug efficacy, predicting drug responses, and identifying potential toxicities; this information will consequently result in the development of safer and more efficient therapeutic strategies. 24,49,69,70 By improving diagnostics, therapies, and patient outcomes, phosphoproteomics research contributes to the ongoing efforts to enhance human health and well-being.…”

Section: Phosphoproteomicsmentioning

confidence: 99%

Exploring the Benefits of Trimethylation Enhancement using Diazomthane (TrEnDi) in Mass Spectropmetry-Based Phosphoproteomics

Vij

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This study provides a comprehensive investigation of TrEnDi for phosphopeptide analysis using mass spectrometry (MS). The goal is to broaden the scope of TrEnDi in phosphopeptide research, emphasizing its versatility and efficacy in peptide analysis. The initial phase involved applying TrEnDi to synthetic peptides, FLEEpXK (X= S, T or Y) and STEALMYCAR, to assess its impact on phosphate and sulfur-containing residues. Through iterative optimization, involving the synthesis of different phosphopeptides and LC-MS parameters, enhanced sensitivity and peptide retention were achieved. The successful application of TrEnDi to synthetic peptides prompted its evaluation on myoglobin and stathmin. TrEnDi-modified peptides demonstrated improved ionization efficiency, retention times, and sensitivity, confirming the successful derivatization. The study highlights future avenues, including exploring N-terminal phosphorylated residues, extending TrEnDi to diverse phosphoproteins, establishing a dedicated database, and integrating it with other methodologies. This research highlights TrEnDi's potential as a valuable tool for comprehensive phosphoproteomic analysis in conjunction with MS.

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Proteomics and Its Application in Pandemic Diseases

Cited by 3 publications

References 42 publications

Exploring peptide studies related to SARS-CoV to accelerate the development of novel therapeutic and prophylactic solutions against COVID-19

Exploring peptide studies related to SARS-CoV to accelerate the development of novel therapeutic and prophylactic solutions against COVID-19

Diverse vaccine platforms safeguarding against SARS-CoV-2 and its variants

Exploring the Benefits of Trimethylation Enhancement using Diazomthane (TrEnDi) in Mass Spectropmetry-Based Phosphoproteomics

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