Proteomics and the Human Metabolome Project

Wishart, David S.

doi:10.1586/14789450.4.3.333

Cited by 41 publications

(23 citation statements)

References 21 publications

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“…Remarkably, the Human Metabolome Project (HMP) [19] aims to identify, quantify and catalogue all metabolites potentially found in human tissues. It is estimated that 8000 metabolites are detectable in the human body, ~3000 of which correspond to endogenous metabolites (Table 1).…”

Section: Metabolomics a Newly Emerging And Not Fully Explored Fi Eldmentioning

confidence: 99%

Approaches for the study of cancer: towards the integration of genomics, proteomics and metabolomics

et al. 2011

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Section: Metabolomics a Newly Emerging And Not Fully Explored Fi Eldmentioning

confidence: 99%

Approaches for the study of cancer: towards the integration of genomics, proteomics and metabolomics

et al. 2011

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“…Proteins use metabolites for their everyday functions in the form of cofactors, signaling molecules or stabilizing agents, and when these proteins eventually decompose they return to a metabolite form. Proteins require metabolites and in return the metabolites require the proteins [3].…”

Section: What Links the ''Omics''?mentioning

confidence: 99%

“…This is known as metabolic fingerprinting. A number of complex diseases, such as atherosclerosis, type 2 diabetes mellitus, and cancer [3] may result from a chronic imbalance of normal metabolism. Therefore, metabonomic based approaches may be of use in identifying surrogate biomarkers of pathological states [21].…”

Section: Applicationsmentioning

confidence: 99%

“…It is defined as ''the quantitative measurement of the dynamic multiparametric metabolic response of living systems to pathophysiologic stimuli or genetic modification'' and is concerned with the high throughput identification and quantification of the small molecule metabolites in the metabolome [2]. The metabolome is the collection of the complete complement of all low molecular weight (<1500 Daltons [Da]) metabolites found in a system (cell, tissue, or organism) under a given set of conditions [2,3]. The metabolome constitutes the interaction between small molecules, such as metabolic substrates and products, lipids, small peptides, vitamins, and other protein cofactors [4,5].…”

Section: Introductionmentioning

confidence: 99%

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Metabonomics: A Useful Tool for the Future Surgeon

Goldsmith

Fenton

Morris‐Stiff

et al. 2010

Journal of Surgical Research

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“…Many cancer cells use glucose inefficiently, through glycolysis rather than oxidative phosphorylation (Warburg effect) (Hsu and Sabatini 2008). For human studies, the Human Metabolome Project attempts to identify and catalog all of the metabolites found in the human bodies, aiming to complete a metabolite inventory for human beings, to generate resources that can facilitate metabolomics research across many different disciplines, as well as to provide detailed information about the linkage between human metabolites and the genes, proteins, and pathways with which they are involved (Wishart et al 2006;Wishart 2007).…”

Section: Metabolomicsmentioning

confidence: 99%

Omics Approaches in Cancer Research

Cho

2009

An Omics Perspective on Cancer Research

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Cancer is a complex genetic, proteomic, and cellular disease caused by multiple factors via genetic mutations (hereditary or somatic) or environmental factors. The emerging omics technologies are being increasingly used for cancer research and personalized drug discovery, including genomics, epigenomics, proteomics, cytomics, metabolomics, interactomics, and bioinformatics. Recent advances in high-throughput omics technologies have provided new opportunity in the molecular analysis of human cancer in an unprecedented speed and details.The detection and treatment of cancer is greatly facilitated by the omics technologies. For example, genomics analysis provides clue for gene regulation and gene knockdown for cancer management. The approval of Mammaprint and Oncotype DX indicates that multiplex diagnostic marker sets are becoming feasible. Discovery of the involvement of microRNAs in human cancers has opened a new page for cancer researchers. Some therapeutic drugs targeting on DNA methylation and histone deacetylation are currently undergoing keen studies. Proteomics also plays an important role in cancer biomarker discovery and quantitative proteome-disease relationships provide a mean for connectivity analysis. Fluorescent dye enables a more reliable analysis and it facilitates the progress of biochip and cytomics. The huge amount of information collected by multiparameter single cell flow-or slide-based cytometry measurements serves to investigate the molecular behavior of cancer cell populations. Cancer is also an ideal field of application for metabolite profiling owing to its unique biochemical properties.It is envisioned that omics technologies will enhance our understanding of molecular signatures of cancer on both qualitative and quantitative patterns. The novel omics technologies have brought powerful abilities to screen cancer cells at the gene, transcript, protein, metabolite, and their interaction network level in searching of novel drug targets, expounding the drug mechanism-of-action, identifying adverse effects in unexpected interaction, validating current drug targets, speeding up the discovery of new targets, exploring potential applications for novel drugs,

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Proteomics and the Human Metabolome Project

Cited by 41 publications

References 21 publications

Approaches for the study of cancer: towards the integration of genomics, proteomics and metabolomics

Approaches for the study of cancer: towards the integration of genomics, proteomics and metabolomics

Metabonomics: A Useful Tool for the Future Surgeon

Omics Approaches in Cancer Research

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