Proteomics: Haematological Perspectives

Tissot, Jean‐Daniel; Schneider, Philippe

doi:10.1007/1-4020-2323-5_3

Cited by 1 publication

(2 citation statements)

References 196 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Removal of fibrinogen (Factor I) is easily obtained by clotting. However, this method induced the disappearance of many other proteins involved in the coagulation process such as prothrombin (Factor II), which is absent in serum [21]. Inversely, many peptides, absent in plasma but detectable in serum, can be identified after coagulation.…”

Section: Overviewmentioning

confidence: 99%

See 1 more Smart Citation

Recent advances in blood‐related proteomics

et al. 2005

Self Cite

View full text Add to dashboard Cite

Service régional vaudois de transfusion sanguine, Lausanne, SwitzerlandBlood is divided in two compartments, namely, plasma and cells. The latter contain red blood cells, leukocytes, and platelets. From a descriptive medical discipline, hematology has evolved towards a pioneering discipline where molecular biology has permitted the development of prognostic and diagnostic indicators for disease. The recent advance in MS and protein separation now allows similar progress in the analysis of proteins. Proteomics offers great promise for the study of proteins in plasma/serum, indeed a number of proteomics databases for plasma/ serum have been established. This is a very complex body fluid containing lipids, carbohydrates, amino acids, vitamins, nucleic acids, hormones, and proteins. About 1500 different proteins have recently been identified, and a number of potential new markers of diseases have been characterized. Here, examples of the enormous promise of plasma/serum proteomic analysis for diagnostic/prognostic markers and information on disease mechanism are given. Within the blood are also a large number of different blood cell types that potentially hold similar information. Proteomics of red blood cells, until now, has not improved our knowledge of these cells, in contrast to the major progresses achieved while studying platelets and leukocytes. In the future, proteomics will change several aspects of hematology.

show abstract

Section: Overviewmentioning

confidence: 99%

“…B lymphocytes eventually differentiate into plasma cells and secrete antibodies, which corresponds to the humoral immune response, whereas T lymphocytes play a determinant role in the cellular immune response. Several studies report on the proteome of T cells [21]. T lymphocytes can be divided into two main classes.…”

Section: Leukocytesmentioning

confidence: 99%