Proteomics in Veterinary Medicine and Animal Science: Neglected Scientific Opportunities with Immediate Impact

Abstract

Animal/veterinary proteomics is an evolving field which holds a great promise not only for fundamental and applied discoveries regarding biology and pathology of domestic species, but can also be implemented in comparative applications of human diseases research. Experimental proteomics in domestic animals have advantages over use of rodents, such as multiple sampling in time series and availability of biological samples in sufficient volume for multiple analyses, such that both experimental and natural disease processes can be investigated. While there are certain technical limitations in the expansion of the field, they can currently be circumvented and in the future mastered with a greater participation of proteomic experts, which will in turn drive the accessibility of species-specific reagents, data volume expansion in bioinformatic databases, and increased funding. This Viewpoint highlights some comparative proteomics studies addressing important issues and encourages readers to expand their horizons of domestic animal proteomics research. It will hopefully inspire new fruitful collaborations between veterinary and animal scientists and proteomic specialists for research in these areas that can have immediate and direct impact on health, society, and the economy.

Mass Spectrometry‐Based Analysis of Time‐Resolved Proteome Quantification

“…These studies can provide information about the biology and pathology of domestic species, and information can also be applicable to human research (reviewed in ref. []). In addition, unlike experiments using rodents, the use of large animals increases the time frame period spanned, increases the availability of sample volume for multiple analyses, and due to the more similar physiology of these animals, the information can be better extended to human studies.…”

Review: Proteomic approaches to control lactational parameters in dairy cows

“…Proteomics which is the application of advanced technology such as nano liquid chromatography (LC) and mass spectrometry (MS) to characterise the full complement of proteins in a biological sample, has had an increasing role in investigations of animal science and veterinary medicine (Almeida et al, 2014). This is not only to provide novel insights into the physiology and pathophysiology of farm and companion animals but also to provide insight into questions on basic scientific questions which includes the processes involved in lactation required for maximising milk production (Bilic et al, 2018). While still to mature into a widespread technology, proteomics and related omic approaches such as metabolomics, the analysis of all metabolites in a sample, there has been considerable progress.…”

Plasma proteomic profiles differ between European and North American myotid bats colonized by Pseudogymnoascus destructans

“…To address the paucity of comparative European and North American Pd infection studies and to get further insights on the molecular mechanisms associated with the infection, we compared the plasma proteomic profile of hibernating North American M. lucifugus and European M. myotis . Blood plasma composition is an important indicator of physiological changes during infection in human (Anderson, Polanski, et al., 2004) and veterinary medicine (Bilić et al., 2018; Ghodasara, Sadowski, Satake, Kopp, & Mills, 2017; Horvatić et al., 2016). Furthermore, proteomic approaches have been used to understand the pathways associated with hibernation in several model and non‐model organisms (Grabek, Martin, & Hindle, 2015), including bats (Hecht et al., 2015).…”