Proteomics of Pancreatic Neuroendocrine Tumors: A Systematic Review

Abstract

: Pancreatic neuroendocrine tumors (PanNETs) are rare tumors having usually an indolent behavior, but sometimes with unpredictable aggressiveness. PanNETs are more often non-functioning (NF), unable to produce functioning hormones, while 10-30% present as functioning (F)-PanNETs, such as insulinomas, gastrinomas, and other rare tumors. Diagnostic and prognostic markers, but also new therapeutic targets, are still lacking. Proteomics techniques represent therefore promising approaches for the future management of PanNETs. We conducted a systematic review to summarize the state of the art of proteomics in PanNETs. A total of 9 studies were included, focusing both on NF- and F-PanNETs. Indeed, proteomics is useful for the diagnosis, the prognosis and the detection of therapeutic targets. However, further studies are required. It is also warranted to standardize the analysis methods and the collection techniques, in order to validate proteins with a relevance in the personalized approach to PanNETs management.

An Insight on Functioning Pancreatic Neuroendocrine Neoplasms

“…Interestingly, different candidate protein biomarkers, such as FASLG, which is negatively correlated with Ki67 and found in lower levels in PanNETs G3 [50], could be useful for diagnosis, prognosis and the detection of therapeutic targets [51].…”