Proteomics study of colorectal cancer and adenomatous polyps identifies TFR1, SAHH, and HV307 as potential biomarkers for screening

Tang, Meifang; Zeng, Liuhong; Zeng, Zhao-Lei; Liu, Jie; Yuan, Jie; Wu, Dongjie; Lü, Ying; Zi, Jian; Ye, Mingzhi

doi:10.1016/j.jprot.2021.104246

Cited by 8 publications

(3 citation statements)

References 48 publications

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“…Colon cancer tissues have much lower level of TfR1 expression than nearby normal tissues, which prevents it from absorbing iron via TfR1 during colorectal carcinogenesis (8). TfR1 has a parallel relationship in individual blood and colon tissue, and it can be used as a potential marker for screening CRC and precancerous lesions together with adenosylhomocysteinase (SAH H) an d immunoglobulin heavy variable 3-7 (HV307) (52). However, there is also study claimed that TfR1 mRNA and protein levels in colon cancer tissue are significantly higher (53).…”

Section: Transferrin Receptormentioning

confidence: 99%

Iron metabolism in colorectal cancer

Huang

et al. 2023

Front. Oncol.

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Iron, as one of the essential trace elements in the human body, is involved in a wide range of critical biochemical reactions and physiological processes, including the maintenance of the normal cell cycle, mitochondrial function, nucleotide metabolism, and immune response. In this context, iron is naturally associated with cancer occurrence. Cellular iron deficiency can induce apoptosis, however, iron can also engage in potentially harmful reactions that produce free radicals because of its capacity to gain and lose electrons. Studies suggest that dietary iron, particularly heme iron, may be one of the leading causes of colorectal cancer (CRC). Moreover, patients with CRC have abnormal iron absorption, storage, utilization, and exportation. Therefore, iron is crucial for the development and progression of CRC. Elaborating on the alterations in iron metabolism during the onset and advancement of CRC would help to further explain the role and mechanism of iron inside the body. Thus, we reviewed the alterations in numerous iron metabolism-related molecules and their roles in CRC, which may provide new clues between iron metabolism and CRC.

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Section: Transferrin Receptormentioning

confidence: 99%

Iron metabolism in colorectal cancer

Huang

et al. 2023

Front. Oncol.

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“…TFR1 is highly expressed in several cancers, including BC and CC, which provide appropriate conditions for ferritin to be used as a targeted nanodrug carrier [126,127]. A recent study reported the use of ferritin cages to mount the flavonoid curcumin, which improved the stability and delivery efficiency of the bioactive and increased its oncogenic effect on BC in vivo and in vitro [128].…”

Section: Potential Applications Of Self-assembled Proteins and Peptid...mentioning

confidence: 99%

Potential Application of Self-Assembled Peptides and Proteins in Breast Cancer and Cervical Cancer

Zhang,

Chen,

Geng

et al. 2023

IJMS

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Ongoing research is gradually broadening the idea of cancer treatment, with attention being focused on nanoparticles to improve the stability, therapeutic efficacy, targeting, and other important metrics of conventional drugs and traditional drug delivery methods. Studies have demonstrated that drug delivery carriers based on biomaterials (e.g., protein nanoparticles and lipids) and inorganic materials (e.g., metal nanoparticles) have potential anticancer effects. Among these carriers, self-assembled proteins and peptides, which are highly biocompatible and easy to standardize and produce, are strong candidates for the preparation of anticancer drugs. Breast cancer (BC) and cervical cancer (CC) are two of the most common and deadly cancers in women. These cancers not only threaten lives globally but also put a heavy burden on the healthcare system. Despite advances in medical care, the incidence of these two cancers, particularly CC, which is almost entirely preventable, continues to rise, and the mortality rate remains steady. Therefore, there is still a need for in-depth research on these two cancers to develop more targeted, efficacious, and safe therapies. This paper reviews the types of self-assembling proteins and peptides (e.g., ferritin, albumin, and virus-like particles) and natural products (e.g., soy and paclitaxel) commonly used in the treatment of BC and CC and describes the types of drugs that can be delivered using self-assembling proteins and peptides as carriers (e.g., siRNAs, DNA, plasmids, and mRNAs). The mechanisms (including self-assembly) by which the natural products act on CC and BC are discussed. The mechanism of action of natural products on CC and BC and the mechanism of action of self-assembled proteins and peptides have many similarities (e.g., NF-KB and Wnt). Thus, natural products using self-assembled proteins and peptides as carriers show potential for the treatment of BC and CC.

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“…With the rapid development of multi-omics analytical techniques, they have been widely used to explore the mechanism of various diseases, including gastrointestinal diseases ( 7 , 8 ), cardiovascular diseases ( 9 ), and cancers ( 10 ). Few research on multi-omics techniques focused on calf diarrhea.…”

Section: Introductionmentioning

confidence: 99%

Differential proteomic of plasma provides a new perspective on scientific diagnosis and drug screening for dampness heat diarrhea in calves

Yan

Zhang²,

Wang³

et al. 2022

Front. Vet. Sci.

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Dampness heat diarrhea (DHD) is one of the most common syndromes of calf diarrhea. Its complex etiology and lack of objective diagnostic criteria bring great challenges to the diagnosis and treatment of this disease. This study aims to screen some prospective diagnostic biomarkers or therapeutic targets for calves with DHD by investigating the differential protein profiles of plasma between DHD calves and clinically healthy calves by mass spectrometry-based proteomic. A total of 120 DHD calves and 90 clinically healthy calves were divided into two groups randomly, 30 DHD calves and 30 clinically healthy calves in the test group, and 90 DHD calves and 60 clinically healthy calves in the validation group. In the test group, a total of 52 proteins were differentially expressed between calves with DHD and clinically healthy calves, 13 proteins were significantly increased and 39 proteins were significantly decreased. The differentially expressed proteins were associated with the intestinal immune network of IgA production, caffeine metabolism, purine metabolism, and PI3K signaling pathway. In the validation group, 13 proteins were selected from 52 differential expression proteins for parallel reaction monitoring validation to verify their associations with DHD calves. The targeted proteomic results showed that fibronectin precursor (FN1) and apolipoprotein C-IV precursor (APOC4) were significantly associated with DHD in calves, and they were downregulated in sick calves. In conclusion, the differential expression of plasma proteins was associated with DHD pathogenesis in calves, and the FN1 and APOC4 might be the potential clinical biomarkers for diagnosis of DHD in calves, and the intestinal immune network of IgA production, caffeine metabolism, purine metabolism, and PI3K signaling pathway are the candidate targets to treat DHD in calves. Our finding provides a reference for further investigating the pathogenesis, developing techniques of diagnosis, and screening treatment drugs for DHD in calves.

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Proteomics study of colorectal cancer and adenomatous polyps identifies TFR1, SAHH, and HV307 as potential biomarkers for screening

Cited by 8 publications

References 48 publications

Iron metabolism in colorectal cancer

Iron metabolism in colorectal cancer

Potential Application of Self-Assembled Peptides and Proteins in Breast Cancer and Cervical Cancer

Differential proteomic of plasma provides a new perspective on scientific diagnosis and drug screening for dampness heat diarrhea in calves

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