Exhumation of the roots of collapsing orogens is a key process in the evolution of mountain belts, which is critical for the understanding of orogenic cycles. From new structural analyses, K-Ar and 40 Ar/ 39 Ar on muscovite, biotite and K-feldspar, and available U-Pb ages, we constrain the cooling and exhumation history of granitic batholiths from the main structural zones of the Variscan orogen in Iberia. We show that: (1) the oldest Ar dated granites (ca. 335 Ma on biotite) record exhumation of gneisses crystallized much earlier (up to ca. 530-510 Ma U-Pb age); (2) granitoids crystallized at ca. 330 Ma record mostly ductile stretching (L-tectonites striking around N-S), consistent with N-S extension (Variscan intra-orogenic collapse); (3) most granites crystallized between ca. 320 and 305 Ma record ductile stretching consistent with deformation along NW-SE to ENE-WSW shear zones during the late-Variscan compression (C3); (4) granites crystallized after 305 Ma record mostly isotropic strain (no visible ductile foliation or lineation), consistent with their emplacement during/after the final collapse of the Variscan orogeny (E2); (5) comparison betweenAr ages on micas and zircon U-Pb ages shows two contrasting situations: (i) similar ages, reflecting crystallization and fast cooling, which can be explained by relatively shallow intrusion and/or fast tectonic uplift; (ii) significant difference between U-Pb and Ar ages, supporting crystallization of deeper seated intrusions and their subsequent uplift for several Ma to tens of Ma; (6) thermochronological modelling on K-feldspar supports significant tectonic exhumation in the core of the chain between ca. 315 and 285 Ma, followed by late-stage passive denudation; 7) Late Carboniferous to early Permian tectonic exhumation was accompanied by significant formation of ore-deposits. Tin deposits occur in pegmatites and/or quartz veins associated with muscovite-rich syn-C3 granites and those of tungsten in quartz veins, breccia pipes and skarns associated with the E2 biotite-rich granites.