Proteus Syndrome: Need for Patient Centric Therapy

Abstract

Proteus syndrome (PS) is a hamartomatous disorder with multisystem involvement that results from mutation in the AKT1gene. Since the symptoms and severity of PS are unique to each patient, diagnosis and treatment become hard for the physician. This article is concentrated upon the identification and recognition of specific characteristics of the disease, pathophysiology, symptoms, diagnosis, treatment and the necessity of advanced diagnosis, effective generalized and personalized therapy, as well as the requirement of new drugs for the management of PS. Detailed studies on the PS and evidence from the case reports revealed the requirement of intensive care, accurate diagnosis, and an effective treatment for each patient preferably patient-centric drug delivery due to the high degree of variation in the symptoms and clinical features among patients.

Formulation of Polymeric Nanosuspension Containing Pramipexole Dihydrochloride and Hesperidin for Improved Treatment of Parkinson’s Diseases

“…It is usually an antioxidant molecule that has lost and needs to stabilize itself by stealing an electron from a nearby molecule. Antioxidant can neutralize the free radical by accepting or donating an electron to eliminate the unpaired condition [8][9][10][11][12]. Antioxidant is effective in the treatment of cancer, coronary heart disease, and neurodegenerative diseases.…”