Protoberberine alkaloids: A review of the gastroprotective effects, pharmacokinetics, and toxicity

Xiang, Ze-Dong; Guan, Hui-Da; Zhao, Xiang; Xie, Qi; Cai, Fu-Jie; Xie, Zhe-Jun; Dang, Rui; Li, Man-Lin; Wang, Chang-Hong

doi:10.1016/j.phymed.2024.155444

Cited by 4 publications

(1 citation statement)

References 166 publications

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“…Studies have indicated that NPs can exert bidirectional influences on pharmacological agents; for example, BBR displays differential modulatory effects on the uptake of nimodipine by cerebral microvascular endothelial cells, with an inhibitory effect at high concentrations and an enhancing effect at low concentrations [ 176 ]. Enzymes involved in metabolism and transport proteins are also instrumental in the modulation of DDIs [ 177 ]. Co-administration of multiple compounds can cause competitive metabolic processes, which may alter drug bioavailability and pharmacokinetics, thus modifying therapeutic outcomes and possibly inducing adverse reactions [ 178 , 179 ].…”

Section: Mechanisms Of Action Toxicity and Drug–drug Interactions Of ...mentioning

confidence: 99%

The Role of Natural Products in Diabetic Retinopathy

Zhao,

Chen,

Yan

2024

Biomedicines

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Diabetic retinopathy (DR) is one of the most severe complications of diabetes mellitus and potentially leads to significant visual impairment and blindness. The complex mechanisms involved in the pathological changes in DR make it challenging to achieve satisfactory outcomes with existing treatments. Diets conducive to glycemic control have been shown to improve outcomes in diabetic patients, thus positioning dietary interventions as promising avenues for DR treatment. Investigations have demonstrated that natural products (NPs) may effectively manage DR. Many types of natural compounds, including saponins, phenols, terpenoids, flavonoids, saccharides, alkaloids, and vitamins, have been shown to exert anti-inflammatory, antioxidant, anti-neovascular, and antiapoptotic effects in vivo and in vitro. Nevertheless, the clinical application of NPs still faces challenges, such as suboptimal specificity, poor bioavailability, and a risk of toxicity. Prospective clinical studies are imperative to validate the therapeutic potential of NPs in delaying or preventing DR.

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Section: Mechanisms Of Action Toxicity and Drug–drug Interactions Of ...mentioning

confidence: 99%

The Role of Natural Products in Diabetic Retinopathy

Zhao,

Chen,

Yan

2024

Biomedicines

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Elucidation of complexation mechanism of rosmarinic acid and berberine

Tsutsumi,

Akita,

Ohata

et al. 2025

Journal of Molecular Structure

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Advancing Cancer Immunotherapy through Engineering New PD-L1 Degraders: A Comprehensive Study from Small Molecules to PD-L1-Specific Peptide–Drug Conjugates

Zeng,

Yang,

et al. 2024

J. Med. Chem.

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Despite the considerable achievements of antibodies targeting PD-1/PD-L1 in cancer immunotherapy, limitations in antitumor immune response and pharmacokinetics hinder their clinical adoption. Small molecules toward PD-L1 degradation signifies an innovative avenue to modulate PD-1/PD-L1 axis. Herein, we unveil a comprehensive engineering involving the development of new PD-L1 degraders based on the berberine (BBR) and palmatine (PMT) bioactive frameworks and explore their translational potential for cancer immunotherapy using a peptide-drug conjugate strategy. Chemical modifications at the O-9 position of PMT dramatically enhance the PD-L1 degradation capacity. Further conjugation of PMT degraders with an anti-PD-L1 peptide featuring disulfide linkers enables efficient GSH-specific prodrug activation, yielding synergistic immunotherapeutic benefits through both external PD-L1 blockade and internal PD-L1 degradation mechanisms. This work elucidates the compelling charm of the discovery and application of PD-L1 degraders, offering solutions to the challenges in advancing cancer immunotherapy in widespread clinics.

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Protoberberine alkaloids: A review of the gastroprotective effects, pharmacokinetics, and toxicity

Cited by 4 publications

References 166 publications

The Role of Natural Products in Diabetic Retinopathy

The Role of Natural Products in Diabetic Retinopathy

Elucidation of complexation mechanism of rosmarinic acid and berberine

Advancing Cancer Immunotherapy through Engineering New PD-L1 Degraders: A Comprehensive Study from Small Molecules to PD-L1-Specific Peptide–Drug Conjugates

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