Protoberberine compounds extracted from Chelidonium majus L. as novel natural photosensitizers for cancer therapy

Warowicka, Alicja; Popenda, Łukasz; Bartkowiak, Grażyna; Musidlak, Oskar; Litowczenko, Jagoda; Kuźma, Dorota; Nawrot, Robert; Jurga, Stefan; Goździcka-Józefiak, Anna

doi:10.1016/j.phymed.2019.152919

Cited by 42 publications

(31 citation statements)

References 33 publications

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“…Nevertheless, the search for new photosensitizers is also an active target for the development of PDT. Several works have reported the use of new compounds as promising photosensitizers [ 162 , 163 , 164 , 165 , 166 , 167 , 168 , 169 , 170 ]. From synthesized compounds based on previous structures to entirely new compounds, the research is in continuously update.…”

Section: Photodynamic Therapymentioning

confidence: 99%

Exploring the Applications of the Photoprotective Properties of Anthocyanins in Biological Systems

Oliveira

Correia

Pereira

et al. 2020

IJMS

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Due to their physical and chemical characteristics, anthocyanins are amongst the most versatile groups of natural compounds. Such unique signature makes these compounds a focus in several different areas of research. Anthocyanins have well been reported as bioactive compounds in a myriad of health disorders such as cardiovascular diseases, cancer, and obesity, among others, due to their anti-inflammatory, antioxidant, anti-diabetic, anti-bacterial, and anti-proliferative capacities. Such a vast number of action mechanisms may be also due to the number of structurally different anthocyanins plus their related derivatives. In this review, we highlight the recent advances on the potential use of anthocyanins in biological systems with particular focus on their photoprotective properties. Topics such as skin aging and eye degenerative diseases, highly influenced by light, and the action of anthocyanins against such damages will be discussed. Photodynamic Therapy and the potential role of anthocyanins as novel photosensitizers will be also a central theme of this review.

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Section: Photodynamic Therapymentioning

confidence: 99%

Exploring the Applications of the Photoprotective Properties of Anthocyanins in Biological Systems

Oliveira

Correia

Pereira

et al. 2020

IJMS

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“…In recent years, the alkaloid has been used to reduce blood glucose and regulate blood lipids [ 12 ]. In our previous studies, we observed strong anti-proliferative activities of berberine and its derivatives extracted from C. majus , one of the most commonly used herbs in folk medicine for the treatment of viral infections, bacterial infections, and cancer [ 15 ]. The plant is a rich source of protoberberine alkaloids such as berberine, dihydroberberine, coptisine, sanguinarine, and protopine.…”

Section: Discussionmentioning

confidence: 99%

“…The purity of the studied alkaloidal fraction, determined on the basis of the HPLC chromatogram ( Supplementary Figure S1a ) was >98%. The HPLC/ESI-MS analyses were carried out as described previously [ 15 ]. The NMR spectra were recorded at 298 K by means of an Agilent DD2 800 MHz spectrometer equipped with a 5 mm 1H/13C/15N triple-resonance probe head.…”

Section: Methodsmentioning

confidence: 99%

Effect of Protoberberine-Rich Fraction of Chelidonium majus L. on Endometriosis Regression

et al. 2021

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Endometriosis is a gynecological disease defined by the presence of endometrial tissue outside the uterus. To date, the effective treatment of this disease is still based on invasive surgery or laparoscopy. Chelidonium majus L. (Papaveraceae) belongs to medicinal, latex-bearing plants. Extracts from the plant are a rich source of pharmacologically active agents. Protoberberine compounds derived from C. majus possess anticancer and antiproliferative activities. In the present study of a rat model of endometriosis, we investigated the influence of the plant protoberberine-rich fraction (BBR) obtained from the medicinal plant C. majus on the development of endometriosis. To understand of BBR therapeutic potential for endometriosis, metabolomics has been applied to study. BBR was prepared from an ethanolic extract of dry plants C. majus. Rats (n = 16) with confirmed endometriosis were treated with BBR administered orally (1 g/kg) for 14 days. Blood serum samples were collected from all of the animals and metabolites were studied using the NMR method. The metabolomic pattern was compared before and after the protoberberine treatment. The performed analysis showed significant changes in the concentrations of metabolites that are involved in energy homeostasis, including glucose, glutamine, and lactate. Histopathological studies showed no recurrence of endometriosis loci after treatment with BBR. The results of the study found that BBR treatment prevents the recurrence of endometriosis in rats. Moreover, metabolomics profiling can be applied to better understand the mechanisms of action of these protoberberine secondary plant metabolites. Our findings provide new insights into the pharmaceutical activity of natural protoberberine plant compounds.

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“…The critical effect of palmatine is due to its ability to inhibit WNV NS2B-NS3 protease (Jia et al, 2010). Columbamine, (-)−8-oxotetrahydropalmatine, oxypalmatine (Gunatilaka, 1998) Papaveraceae Chelidonium majus Berberine, coptisine, chelidonine, chelerythrine, sanguinarine, and protopine (Warowicka et al, 2019) Ranunculaceae Thalictrum sp Thalifendine, thalifendlerine, thalidastine, coptisine, berberine, jatrorrhizine Shamma and Dudock (1968) Protoberberine alkaloids are structurally related compounds. Many of the medicinal plants containing these alkaloids are exhibiting antiviral properties.…”

Section: Palmatinementioning

confidence: 99%

“…Protoberberines are one of the essential group of isoquinoline alkaloids (Warowicka et al, 2019). Isoquinolines are one of the diverse and most abundant groups of natural products with various pharmaceutical properties (Qing et al, 2017).…”

Section: Introductionmentioning

confidence: 99%

Yellow Medicine of Nature- The future Chartbuster Protoberberine Antivirals

Narasimhan

2021

ijrps

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Emerging viral diseases are one of the principal threat towards the plants, animals and humans. Viruses are fast evolving, resulting in reduced effectiveness of existing drugs and vaccines. At this juncture, the importance of traditional medicine, as well as medicinal plant active principles, occupies central attention of researchers across the world. Protoberberine alkaloids, an essential group of isoquinoline family of alkaloids, exhibit properties were affecting the life cycle of DNA and RNA viruses. However, from this protoberberine group, only berberine alkaloid has been studied in detail for its mechanism of action. Berberine is useful both in the case of enveloped and non-enveloped viruses. Berberine inhibits viral life cycle by modulating NF-kB signalling, targeting viral glycoproteins and downregulation of MEK-ERK signalling. Apart from this, berberine also inhibits ACE. All protoberberine alkaloids share a characteristic protoberberine skeleton. The protoberberine containing botanicals also exhibited antiviral properties. Therefore protoberberine alkaloids and protoberberine containing botanicals are interesting to experiment in detail for their antiviral properties and mechanism of action in emerging viral diseases of plants, animals and humans.

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Protoberberine compounds extracted from Chelidonium majus L. as novel natural photosensitizers for cancer therapy

Cited by 42 publications

References 33 publications

Exploring the Applications of the Photoprotective Properties of Anthocyanins in Biological Systems

Exploring the Applications of the Photoprotective Properties of Anthocyanins in Biological Systems

Effect of Protoberberine-Rich Fraction of Chelidonium majus L. on Endometriosis Regression

Yellow Medicine of Nature- The future Chartbuster Protoberberine Antivirals

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