Protocol for diversion of confirmed positive bulk raw milk tankers to calf ranches – A review of the Pharmacokinetics of tetracyclines and sulfonamides in veal calves

DeDonder, Keith D.; Gehring, R.; Tell, Lisa A.; Riviere, Jim E.

doi:10.1017/s1466252316000098

Cited by 4 publications

(4 citation statements)

References 13 publications

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“…For OTC bioequivalence and pharmacokinetics studies, most investigations have been conducted in cattle and chickens, but fewer in pigs (6, 10, 25–28). …”

Section: Introductionmentioning

confidence: 99%

Evaluation of Bioequivalence of Two Long-Acting 20% Oxytetracycline Formulations in Pigs

et al. 2017

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The aim of this study was to explore the bioequivalence of long-acting oxytetracycline in two formulations, a reference formulation (Terramycin 20% LA, Pfizer) and a test one (Kangtekang 20% LA, Huishen). Both formulations were administered intramuscularly at 20 mg/kg body weight at each of 24 healthy animals during a two-period crossover parallel experimental design. The oxytetracycline (OTC) concentrations in plasma were measured by high-performance liquid chromatography, and the limit of quantification was 0.05 µg/ml with a recovery ratio of above 90%. Moreover, the descriptive pharmacokinetics parameters (Cmax, AUC0–144h, and AUC0–∞) were calculated and compared under analysis of variance, and 90% confidence interval (CI) were compared, except for Tmax analyzed by non-parametric tests based on Wilcoxons’s signed rank test. The comparison results of Cmax, AUC0–144h, AUC0–∞, and Tmax were 5.066 ± 0.486, 5.071 ± 0.877 µg/ml, 118.926 ± 13.259, 126.179 ± 17.390 µg h/ml, 123.087 ± 13.906, 130.732 ± 18.562 µg h/ml, 0.740 ± 0.278, 0.650 ± 0.258 h, respectively, and did not reveal any significant differences. In addition, 90% CIs of these ratios for reference and test product were within an interval of 80–125%, and the relative bioavailability of test one was (94.291 ± 15.287)%. Therefore, it has been concluded that test OTC was bioequivalent to the reference formulation in pigs.

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“…For OTC bioequivalence and pharmacokinetics studies, most investigations have been conducted in cattle and chickens, but fewer in pigs (6, 10, 25–28). …”

Section: Introductionmentioning

confidence: 99%

Evaluation of Bioequivalence of Two Long-Acting 20% Oxytetracycline Formulations in Pigs

et al. 2017

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“…This milk can be used to feed calves to avoid a total loss. However, to neutralize the risk of detecting drugs in them, it is essential to wait twenty days of quarantine so that the residue tests come out negative [150].…”

Section: Nutritionmentioning

confidence: 99%

Disciplinary Categorization of the Cattle Supply Chain—A Review and Bibliometric Analysis

et al. 2022

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Global warming is a problem that threatens humanity, with livestock being one of the causes. A systematic literature review was carried out by using some appropriate elements of the PRISMA statement to identify disciplines that work to mitigate the effects of the livestock industry by organizing them according to their approach to addressing this problem. The main objective is to find information and classify the disciplines, papers, literature review methodologies, research gaps, authors, and journals developing the management of the cattle supply chain. This paper could analyze and mitigate the adverse effects on society and the environment generated by the industry, organizing them according to their approach. Twenty databases were consulted between March and May 2020, from which 146 review documents were chosen. The papers reviewed were published between 2003 and 2020. The eligibility criteria for selection were open access to the full text, publication in an indexed journal, and a focus on any discipline related to cattle. The unselected papers did not have DOIs or duplicates, and those focused on other types of meat and book chapters. Subsequently, the information in the selected papers was described and consolidated, and these papers had 602 authors and were from 99 journals. Next, a discipline categorization was proposed. The results were organized, showing that among all the analysis criteria, the category of veterinary medicine had the best results in terms of indicators; therefore, additional research is needed on the other disciplines, especially in culture, technology, management, quality control, tanneries, and transportation, as there was less research within these disciplines. It is recommended that research on a mix of the different proposed disciplines be conducted. The proposed categorization’s main contribution is to identify and group the cattle supply chain’s different disciplines and the definition of research gaps organized under a structure organizational management model. Finally, a multicriteria selection methodology must be used that prioritizes the discipline categories proposed in this review to guide future research.

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“…Finally, FARAD recently developed a strategy for the estimation of appropriate WDIs that allow bulk milk (pooled milk from multiple cows generally from multiple operations) from tankers contaminated with violative drug residues that is unsuitable for human consumption to be repurposed and fed to calves instead of being discarded. 31…”

Section: Estimation Of Wdis Following Contaminant Exposurementioning

confidence: 99%

Guide to FARAD resources: historical and future perspectives

Riviere¹,

Tell²,

Baynes³

et al. 2017

javma

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Protocol for diversion of confirmed positive bulk raw milk tankers to calf ranches – A review of the Pharmacokinetics of tetracyclines and sulfonamides in veal calves

Cited by 4 publications

References 13 publications

Evaluation of Bioequivalence of Two Long-Acting 20% Oxytetracycline Formulations in Pigs

Evaluation of Bioequivalence of Two Long-Acting 20% Oxytetracycline Formulations in Pigs

Disciplinary Categorization of the Cattle Supply Chain—A Review and Bibliometric Analysis

Guide to FARAD resources: historical and future perspectives

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