Protocol for SARS-CoV-2 infection of kidney organoids derived from human pluripotent stem cells

Garreta, Elena; Moya-Rull, Daniel; Stanifer, Megan L.; Monteil, Vanessa; Prado, Patricia; Marco, Andrés; Tarantino, Carolina; Gallo, Maria; Jonsson, Gustav; Hagelkrüys, Astrid; Mirazimi, Alì; Boulant, Steeve; Penninger, Josef; Montserrat, Núria

doi:10.1016/j.xpro.2022.101872

Cited by 2 publications

(1 citation statement)

References 5 publications

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“…But when the COVID-19 pandemic hit, the potential of organoids to study infectious diseases truly unfolded. Recent studies demonstrate the ability of kidney ( Garreta et al, 2022 ; Jansen et al, 2022a ; Monteil et al, 2020 ), intestine ( Giobbe et al, 2021 ; Lamers et al, 2020 ; Stanifer et al, 2020 ; Zhou et al, 2020 ), colon ( Han et al, 2021 ), liver ( Richards et al, 2022 ; Yang et al, 2020 ), heart ( Mills et al, 2021 ; Sharma et al, 2020 ; Wong et al, 2020 ), lung ( Han et al, 2021 ; Lamers et al, 2021a ), brain ( Andrews et al, 2022 ; Mesci et al, 2022 ; Pellegrini et al, 2020b ; Song et al, 2021a ) and vascular ( Monteil et al, 2020 ) organoids to model and understand SARS-CoV-2 infection and reveal their potential as a drug-testing platform. For instance, researchers have used iPSC-derived respiratory and colorectal organoids in high-throughput screening of U.S. Food and Drug Administration (FDA)-approved drugs that reduce SARS-CoV-2 replication ( Han et al, 2021 ).…”

Section: Organoid Models For the Neurological Implications Of Acute C...mentioning

confidence: 99%

Understanding the neurological implications of acute and long COVID using brain organoids

García-González,

Martí-Sarrias,

Puertas

et al. 2023

Disease Models &Amp; Mechanisms

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As early as in the acute phase of the coronavirus disease 2019 (COVID-19) pandemic, the research community voiced concerns about the long-term implications of infection. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), like many other viruses, can trigger chronic disorders that last months or even years. Long COVID, the chronic and persistent disorder lasting more than 12 weeks after the primary infection with SARS-CoV-2, involves a variable number of neurological manifestations, ranging from mild to severe and even fatal. In vitro and in vivo modeling suggest that SARS-CoV-2 infection drives changes within neurons, glia and the brain vasculature. In this Review, we summarize the current understanding of the neuropathology of acute and long COVID, with particular emphasis on the knowledge derived from brain organoid models. We highlight the advantages and main limitations of brain organoids, leveraging their human-derived origin, their similarity in cellular and tissue architecture to human tissues, and their potential to decipher the pathophysiology of long COVID.

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Section: Organoid Models For the Neurological Implications Of Acute C...mentioning

confidence: 99%

Understanding the neurological implications of acute and long COVID using brain organoids

García-González,

Martí-Sarrias,

Puertas

et al. 2023

Disease Models &Amp; Mechanisms

View full text Add to dashboard Cite

show abstract

Single-Cell Advances in Investigating and Understanding Chronic Kidney Disease and Diabetic Kidney Disease

Bhayana,

Schytz,

Bisgaard Olesen

et al. 2024

The American Journal of Pathology

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Protocol for SARS-CoV-2 infection of kidney organoids derived from human pluripotent stem cells

Cited by 2 publications

References 5 publications

Understanding the neurological implications of acute and long COVID using brain organoids

Understanding the neurological implications of acute and long COVID using brain organoids

Single-Cell Advances in Investigating and Understanding Chronic Kidney Disease and Diabetic Kidney Disease

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