Protocol for the specialist supervised individualised multifactorial treatment of new clinically diagnosed type 2 diabetes in general practice (IDA): a prospective controlled multicentre open-label intervention study

Stidsen, Jacob V; Nielsen, Jens Steen; Henriksen, Jan Erik; Friborg, Søren; Thomsen, Reimar Wernich; Olesen, Thomas Bastholm; Olsen, Michael Hecht; Beck‐Nielsen, Henning

doi:10.1136/bmjopen-2017-017493

Cited by 9 publications

(8 citation statements)

References 51 publications

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“…More than 24,000 cardiac computed tomography (CT) scans were performed between 2007 and 2017 as part of clinical examinations at Odense University Hospital, or as part of research studies at five centres (Odense, Svendborg, Vejle, Esbjerg, Silkeborg). After approval from the Danish Data Protection Agency, traditional cardiovascular risk factors and CAC scores were collected from the electronic patient databases at Odense University Hospital, the Western Denmark Heart Registry [ 12 ], The National Danish Ablation Database [ 13 ], and research databases (DANCAVAS [ 14 ], DanRisk [ 15 ], IDA [ 16 ], MYODAN [ 17 ], NOTICE [ 18 ], AMFAST [ 19 ], and Ilangkovan N et al [ 20 ].). The study participants’ medication status since 2004 was collected from the Danish National Health Service Prescription Database (DNHSPD) [ 21 ].…”

Section: Methodsmentioning

confidence: 99%

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Extent of arterial calcification by conventional vitamin K antagonist treatment

et al. 2020

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Background and aims Vitamin K antagonists (VKA) remain the most frequently prescribed oral anticoagulants worldwide despite the introduction of non-vitamin K antagonist oral anticoagulants (NOAC). VKA interfere with the regeneration of Vitamin K1 and K2, essential to the activation of coagulation factors and activation of matrix-Gla protein, a strong inhibitor of arterial calcifications. This study aimed to clarify whether VKA treatment was associated with the extent of coronary artery calcification (CAC) in a population with no prior cardiovascular disease (CVD). Methods We collected data on cardiovascular risk factors and CAC scores from cardiac CT scans performed as part of clinical examinations (n = 9,672) or research studies (n = 14,166) in the period 2007–2017. Data on use of anticoagulation were obtained from the Danish National Health Service Prescription Database. The association between duration of anticoagulation and categorized CAC score (0, 1–99, 100–399, ≥400) was investigated by ordered logistic regression adjusting for covariates. Results The final study population consisted of 17,254 participants with no prior CVD, of whom 1,748 and 1,144 had been treated with VKA or NOAC, respectively. A longer duration of VKA treatment was associated with higher CAC categories. For each year of VKA treatment, the odds of being in a higher CAC category increased (odds ratio (OR) = 1.032, 95%CI 1.009–1.057). In contrast, NOAC treatment duration was not associated with CAC category (OR = 1.002, 95%CI 0.935–1.074). There was no significant interaction between VKA treatment duration and age on CAC category. Conclusions Adjusted for cardiovascular risk factors, VKA treatment–contrary to NOAC—was associated to higher CAC category.

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Section: Methodsmentioning

confidence: 99%

“…Ablation Database [13], and research databases (DANCAVAS [14], DanRisk [15], IDA [16], MYODAN [17], NOTICE [18], AMFAST [19], and Ilangkovan N et al [20].). The study participants' medication status since 2004 was collected from the Danish National Health Service Prescription Database (DNHSPD) [21].…”

Section: Plos Onementioning

confidence: 99%

Extent of arterial calcification by conventional vitamin K antagonist treatment

et al. 2020

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“…This cross-sectional study used baseline data from a prospective controlled multicenter open-label intervention study—The Specialist Supervised Individualized Treatment of New Clinically Diagnosed Type 2 Diabetes in General Practice (IDA) ( 14 ). A total of 1,172 individuals with type 2 diabetes gave written informed consent to participate in IDA.…”

Section: Methodsmentioning

confidence: 99%

“…This procedure did not change the final number of observations as the inclusion criteria was still met. For more detailed information of the setup we refer to the study protocol ( 14 ).…”

Section: Methodsmentioning

confidence: 99%

Accelerometer-derived physical activity and sedentary behaviors in individuals with newly diagnosed type 2 diabetes: A cross-sectional study from the Danish nationwide DD2 cohort

Domazet

Tarp

Thomsen

et al. 2023

Front. Sports Act. Living

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IntroductionHabitual physical activity behaviors of individuals with new-onset type 2 diabetes are largely unknown. We aimed to investigate accelerometer-derived physical activity behaviors in individuals with newly diagnosed type 2 diabetes. We also examined sociodemographic and health-related correlates of a high-risk physical activity profile.MethodsThis cross-sectional study used data from 768 participants enrolled in an intervention study nested within the Danish Centre for Strategic Research in Type 2 diabetes (DD2) cohort. Physical activity was assessed by 24-h dual monitor accelerometry. Prevalence ratios of having a high-risk physical activity profile were estimated using Poisson regression adjusted for age and sex.ResultsStudy participants spent on average 9.7 (25th and 75th percentiles, 8.3; 11.1) hours/day sitting, walked for 1.1 (0.8; 1.6) hours/day and accumulated 4,000 (2,521; 5,864) steps/day. Still, 62% met the recommendations for physical activity. Characteristics associated with a high-risk physical activity profile (observed in 24.5% of participants) included older age, higher body mass index (BMI), unemployment, retirement, comorbidities, and current smoking. Hence, participants aged 60–69, 70–79 and 80+ years had prevalence ratios of 2.12 (95% CI 1.31; 3.42), 1.99 (1.18; 3.34) and 3.09 (1.42; 6.75) for a high-risk activity profile, respectively, versus participants <50 years. BMI values of 30–39 and 40+ were associated with 1.83 (1.06; 3.15) and 3.38 (1.88; 6.05) higher prevalence ratios compared to normal-weight. Unemployment or retirement was associated with 1.62 (1.09; 2.41) and 2.15 (1.37; 3.39) times higher prevalence ratios, compared to individuals in the working force. Having a Charlson Comorbidity Index score of 1–2 or 3+ was associated with 1.36 (1.03–1.79) and 1.90 (1.27–1.84) higher prevalence ratios, while current smoking was associated with a prevalence ratio of 1.72 (1.25; 2.35) compared to never smokers.ConclusionThis study shows that 62% of individuals with newly diagnosed type 2 diabetes met the recommendations for physical activity. Still, the majority of participants were also highly sedentary and accumulated very few daily steps, emphasizing the need for focusing on both increasing physical activity and reducing sedentary behaviors in the prevention of diabetes-related complications. Individuals with a high-risk physical activity profile were characterized by more obesity, socioeconomic inequalities, advanced age and comorbidities.Trial registration number: NCT02015130.

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“…This population-based cross-sectional study is nested in the "Individually tailored treatment in type 2 diabetes" (IDA) study (Stidsen et al, 2017), which is imbedded in the "Danish Centre for Strategic Research in Type 2 Diabetes" (DD2) cohort study (Nielsen et al, 2012). In brief, the IDA study aims to investigate the effect of individualized treatment in general practice for patients with newly diagnosed T2DM.…”

Section: Research Design and Study Populationmentioning

confidence: 99%

Retinal microvascular markers in type 2 diabetes subphenotypes and latent autoimmune diabetes of adults

Pedersen

Stidsen

Rasmussen

et al. 2023

Acta Ophthalmologica

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Purpose To estimate if newly diagnosed patients with different subphenotypes of type 2 diabetes (T2DM) or latent autoimmune diabetes of adults (LADA) differ with respect to subclinical retinal microvascular structure or diabetic retinopathy (DR). Methods This population‐based, cross‐sectional study of 340 patients (675 eyes) classified patients with recently diagnosed T2DM in different subphenotypes according to beta cell function and insulin sensitivity in to; classical (n = 218), hyperinsulinaemic (n = 86), insulinopenic (n = 20), or LADA (n = 16). Retinal 6‐field images were graded according to the International Clinical DR Severity Scale by a retinal expert. Retinal microvascular structures were analysed in eyes by a semiautomatic software. Results Median age and duration of diabetes were 58.1 (49.9; 65.5) and 0.9 (0.5; 2.4) years, respectively, and 56.8% were male. In a multivariate linear mixed model regression analysis of eyes without DR (n = 570), there was no statistically significant difference in retinal venular or arteriolar width between subtypes and patients with classical T2DM. In addition, eyes from different subphenotypes did not differ according to vessel density, tortuosity or fractal dimension. In a multivariate logistic regression model adjusted for age, sex, HbA1c, diabetes duration, body mass index, mean arterial blood pressure and history of cardiovascular disease, there was a tendency towards persons with hyperinsulinaemic T2DM to be more likely to have DR (OR 1.97, 95% CI 0.95; 4.09) compared to classical T2DM. Conclusion We found no difference in retinal microvascular structure in patients with newly diagnosed subtypes of T2DM. However, DR may be more prevalent in newly diagnosed patients with hyperinsulinaemic T2DM compared to individuals with classical T2DM.

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Protocol for the specialist supervised individualised multifactorial treatment of new clinically diagnosed type 2 diabetes in general practice (IDA): a prospective controlled multicentre open-label intervention study

Cited by 9 publications

References 51 publications

Extent of arterial calcification by conventional vitamin K antagonist treatment

Extent of arterial calcification by conventional vitamin K antagonist treatment

Accelerometer-derived physical activity and sedentary behaviors in individuals with newly diagnosed type 2 diabetes: A cross-sectional study from the Danish nationwide DD2 cohort

Retinal microvascular markers in type 2 diabetes subphenotypes and latent autoimmune diabetes of adults

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