Objective: To present the evidence available in the literature on nursing care for users with sickle cell anemia. Methodology: Integrative, qualitative review, with database research. 15 articles published between 2015-2022 were considered. The descriptors were used: “Sickle cell anemia”, “Nursing Care”, “Nursing” and “Hemotherapy Services”. Results: Two thematic categories were found: Nursing care for students with sickle cell anemia; Nursing care for users with sickle cell anemia in the Health Care Network services. Final considerations: Care for this population stands out, with actions that begin from the newborn stage and are also aimed at the black population, as well such as using approaches beyond conventional ones, such as pain relief strategies and helping people deal with a health problem that will accompany them throughout their lives.