Proton beam radiotherapy versus fractionated stereotactic radiotherapy for uveal melanomas: A comparative study

Weber, Damien Charles; Bogner, Joachim; Verwey, Jorn; Georg, Dietmar; Dieckmann, Karin; Escudé, L.; Caro, M.; Pötter, Richard; Goitein, Gudrun; Lomax, Anthony; Miralbell, Raymond

doi:10.1016/j.ijrobp.2005.01.057

Cited by 65 publications

(45 citation statements)

References 41 publications

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“…The primary specification of the treatment-planning concept is to have optimum coverage as the planning priority. This was also confirmed with 2 studies by Weber et al [18,19]. They reported that CI was similar irrespective of target volume when proton and photons were compared.…”

Section: Discussionsupporting

confidence: 82%

Dosimetric Comparison of Pencil-Beam Scanning and Photon-Based Radiation Therapy as a Boost in Carcinoma of Cervix

Sharma

Hug

Bhushan

et al. 2017

International Journal of Particle Therapy

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Purpose: Brachytherapy is essential for local treatment in cervical carcinoma, but some patients are not suitable for it. Presently, for these patients, the authors prefer a boost by using intensity-modulated radiation therapy (IMRT). The authors evaluated the dosimetric comparison of proton-modulated radiation therapy versus IMRT and volumetric-modulated arc therapy (VMAT) as a boost to know whether protons can replace photons. Patients and Methods: Five patients who received external beam radiation therapy to the pelvis by IMRT were reviewed. Three different plans were made, including pencil beam scanning (PBS), IMRT, and VMAT. The prescribed planning target volume (PTV) was 20 Gy in 4 fractions. The dose to 95% PTV (D 95% ), the conformity index, and the homogeneity index were evaluated for PTV. The D max , D 2cc , and D mean were evaluated for organs at risk along with the integral dose of normal tissue and organs at risk. Results: The PTV coverage was optimal and homogeneous with modulated protons and photons. For PBS, coverage D 95% was 20.01 6 0.02 Gy (IMRT, 20.08 6 0.06 Gy; VMAT, 20.1 6 0.04 Gy). For the organs at risk, D max of the bladder for PBS was 21.05 6 0.05 Gy (IMRT, 20.8 6 0.21 Gy; VMAT, 21.65 6 0.41 Gy) while the D max for the rectum for PBS was 21.04 6 0.03 Gy (IMRT, 20.81 6 0.12 Gy; VMAT, 21.66 6 0.38 Gy). Integral dose to normal tissues in PBS was 14.17 6 2.65 Gy (IMRT, 25.29 6 6.35 Gy; VMAT, 25.24 6 6.24 Gy). Conclusions: Compared with photons, modulated protons provide comparable conformal plans. However, PBS reduces the integral dose to critical structures significantly compared with IMRT and VMAT. Although PBS may be a better alternative for such cases, further research is required to substantiate such findings.

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Section: Discussionsupporting

confidence: 82%

Dosimetric Comparison of Pencil-Beam Scanning and Photon-Based Radiation Therapy as a Boost in Carcinoma of Cervix

Sharma

Hug

Bhushan

et al. 2017

International Journal of Particle Therapy

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“…Dose conformation can be as good in SRT for photon technique as for protons (10). As it has been demonstrated that dose reduction to optic nerve or macula is equal for both beam qualities in case where the tumor is at a distance < 2 mm.…”

Section: Discussionmentioning

confidence: 99%

“…As it has been demonstrated that dose reduction to optic nerve or macula is equal for both beam qualities in case where the tumor is at a distance < 2 mm. Only organs at risk, such as the lacrimal glands, were found to profit from proton irradiation [10]. The treatment time is longer for photon than for proton treatment.…”

Section: Discussionmentioning

confidence: 99%

Stereotactic Photon Beam Irradiation of Uveal Melanoma: Indications and Experience at the University of Vienna since 1997

et al. 2007

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“…For treatment planning the same goal as for patient treatments was applied, i.e. to fully encompass the PTV with the 80% isodose, while minimizing the dose to both optic nerve and lens [2,6,8]. A prescription dose of 5 Gy per fraction was chosen to ensure that the irradiation dose falls completely in the sensitivity range of EBT films.…”

Section: Treatment Plan Categoriesmentioning

confidence: 99%

“…In 1997 the Department of Radiotherapy, Medical University Vienna/Vienna General Hospital, started to treat uveal melanoma with linac based stereotactic radiotherapy (SRT). Although the standard external beam therapy for uveal melanoma remains proton beam therapy, the Vienna group developed an SRT treatment concept based on conformal mMLC treatments that are delivered in a computer controlled gated manner [6][7][8].…”

Section: Introductionmentioning

confidence: 99%

Multi-dimensional dosimetric verification of stereotactic radiotherapy for uveal melanoma using radiochromic EBT film

Sturtewagen

Fuß

Paelinck

et al. 2008

Zeitschrift für Medizinische Physik

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Proton beam radiotherapy versus fractionated stereotactic radiotherapy for uveal melanomas: A comparative study

Cited by 65 publications

References 41 publications

Dosimetric Comparison of Pencil-Beam Scanning and Photon-Based Radiation Therapy as a Boost in Carcinoma of Cervix

Dosimetric Comparison of Pencil-Beam Scanning and Photon-Based Radiation Therapy as a Boost in Carcinoma of Cervix

Stereotactic Photon Beam Irradiation of Uveal Melanoma: Indications and Experience at the University of Vienna since 1997

Multi-dimensional dosimetric verification of stereotactic radiotherapy for uveal melanoma using radiochromic EBT film

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