Proton Beam Therapy for Unresectable Malignancies of the Nasal Cavity and Paranasal Sinuses

Zenda, Sadamoto; Kohno, Ryosuke; Kawashima, Mitsuhiko; Arahira, Satoko; Nishio, Teiji; Tahara, Makoto; Hayashi, Ryuichi; Kishimoto, Seiji; Ogino, Takashi

doi:10.1016/j.ijrobp.2010.08.009

Cited by 82 publications

(32 citation statements)

References 21 publications

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“…53,57,65 A recent report from Japan described long-term toxicities after proton therapy in 90 patients with nasal cavity, paranasal sinus, or skull base malignancies. 52 Late toxicities reached grade 3 in 17 patients (19%) and grade 4 in 6 patients (7%) (encephalomyelitis infection in 2 patients, optic nerve disorder in 4 patients).…”

Section: Particle Therapiesmentioning

confidence: 99%

Head and Neck Cancers, Version 1.2015

Pfister

Spencer

Brizel

et al. 2015

J Natl Compr Canc Netw

200

246

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These NCCN Guidelines Insights focus on recent updates to the 2015 NCCN Guidelines for Head and Neck (H&N) Cancers. These Insights describe the different types of particle therapy that may be used to treat H&N cancers, in contrast to traditional radiation therapy (RT) with photons (x-ray). Research is ongoing regarding the different types of particle therapy, including protons and carbon ions, with the goals of reducing the long-term side effects from RT and improving the therapeutic index. For the 2015 update, the NCCN H&N Cancers Panel agreed to delete recommendations for neutron therapy for salivary gland cancers, because of its limited availability, which has decreased over the past 2 decades; the small number of patients in the United States who currently receive this treatment; and concerns that the toxicity of neutron therapy may offset potential disease control advantages.

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Section: Particle Therapiesmentioning

confidence: 99%

Head and Neck Cancers, Version 1.2015

Pfister

Spencer

Brizel

et al. 2015

J Natl Compr Canc Netw

200

246

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“…Regarding the clinical outcomes after PBT, several studies including a study from our institution demonstrated that 5-year OS ranged from 70–80%, although the histological types of patients analyzed were not homogenous. These results indicated that clinical outcomes were slightly better than those after conventional radiation therapy [9, 14, 15, 16]. The main advantages of radiation therapy for nasal cavity and paranasal malignancies are to preserve organs and their functions by delivering enough total dose to the tumors while sparing excessive doses to the adjacent critical normal structures such as the brain, brainstem and the optic structures.…”

Section: Discussionmentioning

confidence: 99%

“…In cases where the disease has spread deeply into the intracranial region, surgical approaches are often complicated by the risk of serious functional deformity and a lack of satisfactory surgical clearance [7, 8]. Therefore, definitive radiation therapies (RTs) including 3D-conformal radiation therapy (3DCRT) or intensity modulated radiation therapy (IMRT) and proton beam therapy (PBT) are often performed as an alternative treatment [2, 4, 9]. …”

Section: Introductionmentioning

confidence: 99%

“…However, Zenda et al reported that patients with nasal or paranasal malignancies occasionally survive for long periods without complete response at the primary tumor site [9]. To our knowledge, however, there have been few reports that have examined response evaluation for nasal or paranasal sinus malignancies after non-surgical approaches.…”

Section: Introductionmentioning

confidence: 99%

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Impact of early radiological response evaluation on radiotherapeutic outcomes in the patients with nasal cavity and paranasal sinus malignancies

Hojo

Zenda

Akimoto

et al. 2012

Journal of Radiation Research

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We analyzed the correlation between primary tumor response within 6 months after radiation therapy (RT) including proton beam therapy (PBT) and progression free survival rate (PFS) in patients with nasal cavity and paranasal sinus malignancies to clarify the impact of early radiological evaluation of treatment response on prognosis. Sixty-five patients treated between January 1998 and December 2008, and whose follow-up duration was more than 2 years were included. The Response Evaluation Criteria in Solid Tumors (version 1.1) was used for the evaluation of treatment. Median age was 59 years (range 21–83 years). Olfactory neuroblastoma (n = 20, 30%) and squamous cell carcinoma (n = 15, 23%) were the major pathological tumor types. The median follow-up duration was 51.6 months. Radiological response evaluation within 6 months after treatment demonstrated that 15% of the patients achieved complete response (CR), and 3-year progression free survival rates of all patients was 49.2%. The 3-year PFS rates according to response for the treatment were 55.6% in the patients with CR and 46.4% in those with non-CR, respectively (P = 0.643). However, the 3-year PFS rates were 80.% in the patients with CR and 10.% in those with non-CR (P = 0.051) in the patients with squamous cell carcinoma (SCC) histology. Radiological response evaluation within 6 months did not have a significant impact on prognosis when analysis included all histology, although early radiological response within 6 months after RT had a borderline significant impact on treatment outcomes for the patients with nasal and paranasal SCC.

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“…The surgical margin was negative for cancer cells. In January 2008, she had developed a recurrence in the left upper eyelid, and underwent radiotherapy with a total dose of 57.6 Gy of proton beam therapy followed by orbital exenteration of the left eye [11,12]. In July 2012, positron emission tomography–computed tomography (PET-CT) revealed a solitary pulmonary nodule 0.5 cm in size in the right upper lobe of the patient’s lung, which had increased to 1.1 cm by September 2013 (Figure 1A).…”

Section: Case Presentationmentioning

confidence: 99%

Surgical treatment of a solitary pulmonary metastasis from eyelid sebaceous carcinoma: report of a case

et al. 2014

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BackgroundOcular sebaceous carcinoma is an uncommon, aggressive ocular neoplasm with potential for regional and distant metastasis.Case presentationA 77-year-old woman was found to have a solitary pulmonary lesion 6 years after the initial treatment of sebaceous carcinoma of the eyelid. Video-assisted lung wedge resection of an undetermined pulmonary nodule was carried out successfully. Microscopically, the tumor showed foamy cytoplasm and atypical nuclei, consistent with metastasis of eyelid sebaceous carcinoma.ConclusionThis is the first case report of resected solitary pulmonary metastasis of eyelid sebaceous carcinoma. Pulmonary resection is a good option for the treatment and diagnosis of metastatic eyelid sebaceous carcinoma.

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Proton Beam Therapy for Unresectable Malignancies of the Nasal Cavity and Paranasal Sinuses

Cited by 82 publications

References 21 publications

Head and Neck Cancers, Version 1.2015

Head and Neck Cancers, Version 1.2015

Impact of early radiological response evaluation on radiotherapeutic outcomes in the patients with nasal cavity and paranasal sinus malignancies

Surgical treatment of a solitary pulmonary metastasis from eyelid sebaceous carcinoma: report of a case

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