Proton Magnetic Resonance Chemical Shift Imaging ( 1 H CSI)-Directed Stereotactic Biopsy

Son, Byung-chul; Kim, M.-C.; Choi, Byung Gil; Kim, E.-N.; Baik, Hyun-Man; Choe, Bo-Young; Shoji, Nobuyuki; Kang, Joon-Ki

doi:10.1007/s007010170137

Cited by 26 publications

(11 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The ratio of specific molecules correlates with a specific group of lesions or with their histological malignancy [24,25,28,29] . Single-voxel spectroscopy can differentiate gliomas according to their degree of malignancy with an accuracy of 86% and can help in the diagnosis of a high-grade glioma with an error of about 5% [32,33] .…”

Section: Introductionmentioning

confidence: 99%

Frameless Stereotactic Cerebral Biopsy: Our Experience in 296 Cases

Frati¹,

Pichierri²,

Bastianello³

et al. 2011

Stereotact Funct Neurosurg

View full text Add to dashboard Cite

Aims: To evaluate the reliability, safety and accuracy of a the frameless stereotactic system in our clinical series and the differences between head fixation by means of a standard Mayfield head holder and the pinless FESS frame, and to evaluate the usefulness of biopsy targeting on the basis of magnetic resonance spectroscopy (MRS) data. Methods: The spectroscopic analysis was used to facilitate the targeting of the lesion. The fusion image function embedded in the Neuronavigation Unit was used postoperatively to assess the level of accuracy of the biopsy. The grading of the glioma specimens was correlated to the spectroscopic data. Results: 296 patients underwent cerebral biopsy in 8 years. The diagnostic yield was 99.7%. The spectroscopic choline/N-acetyl aspartate ratio in different areas of the same tumor correlated well with the histological grading of the lesion. Conclusion: The frameless stereotactic systems guarantee excellent biopsy results. Advanced imaging, in particular MRS, facilitates the correct targeting of nonenhancing lesions.

show abstract

Section: Introductionmentioning

confidence: 99%

Frameless Stereotactic Cerebral Biopsy: Our Experience in 296 Cases

Frati¹,

Pichierri²,

Bastianello³

et al. 2011

Stereotact Funct Neurosurg

View full text Add to dashboard Cite

show abstract

“…However, changes on MRimages are nonspecific and differential diagnosis from ischemia, encephalitis, lymphoma, subacute sclerosing panencephalitis, leukoencephalopathies and multiple sclerosis is necessary. Neither 1 1), and an increase of Cho reflecting an increased membraneturnover and increased cellularity (12,13). A recent study reported that MR spectroscopy of eight patients with GC also showed neoplastic patterns and that the histopathologic grade of GC was correlated with the extent of Cho/NAAlevel (14).…”

Section: Discussionmentioning

confidence: 99%

Gliomatosis Cerebri Involving the Lumbosacral Spinal Cord

et al. 2003

View full text Add to dashboard Cite

show abstract

“…Previously, it was shown that high-grade gliomas revealed a 2-to 3-fold higher choline concentration compared with low-grade tumors [21] . MRS-guided stereotactic biopsy of brain tumors was shown to be feasible in several studies [22][23][24][25][26][27][28][29] . The purpose of this prospective study was to evaluate the value of CSI-guided stereotactic biopsy in the area of the highest choline concentration in suggestive low-grade gliomas.…”

Section: H-chemical-shift Imaging Of Cholinementioning

confidence: 99%

Stereotactic Biopsy in Gliomas Guided by 3-Tesla <sup>1</sup>H-Chemical-Shift Imaging of Choline

Hermann¹,

Hattingen

Krauss

et al. 2008

Stereotact Funct Neurosurg

View full text Add to dashboard Cite

Objective: To investigate chemical-shift imaging (CSI) to guide stereotactic biopsy of the choline ‘hot spot’ in cerebral lesions suggestive of low-grade glioma. Methods: Nine patients with hyperintense lesions on T₂-weighted images of standard magnetic resonance imaging without contrast enhancement underwent advanced magnetic resonance studies. These studies included 3-dimensional T₁-weighted sequences with contrast enhancement and 2-dimensional ¹H-CSI spectroscopy at 3 T. Signal intensity maps with relative signal intensities for choline were generated. The region with the highest choline signal intensity (the hot spot) was chosen as the target for stereotactic biopsy. The histopathological results were correlated with the increase in choline. Results: All spectroscopic data were of sufficient quality. In 5 instances the neuropathological diagnosis was grade II glioma, according to the WHO classification, and in 4 instances it was grade III glioma. According to the CSI criteria, all grade III gliomas and 4 of the 5 grade II gliomas were classified correctly. One grade II glioma was overestimated by CSI as a high-grade glioma. Conclusion:¹H-CSI-guided stereotactic biopsy may offer advantages as compared to conventional stereotactic biopsy. The biopsy of the choline hot spot in suggestive low-grade gliomas may help to identify focal points of higher tumor malignancy independent of contrast enhancement.

show abstract

Proton Magnetic Resonance Chemical Shift Imaging ( 1 H CSI)-Directed Stereotactic Biopsy

Cited by 26 publications

References 8 publications

Frameless Stereotactic Cerebral Biopsy: Our Experience in 296 Cases

Frameless Stereotactic Cerebral Biopsy: Our Experience in 296 Cases

Gliomatosis Cerebri Involving the Lumbosacral Spinal Cord

Stereotactic Biopsy in Gliomas Guided by 3-Tesla <sup>1</sup>H-Chemical-Shift Imaging of Choline

Contact Info

Product

Resources

About