Proton magnetic resonance spectroscopy in anorexia nervosa: correlations with cognition

Ohrmann, Patricia; Kersting, Anette; Suslow, Thomas; Lalee-Mentzel, Judith; Donges, Uta‐Susan; Fiebich, Martin; Arolt, Volker; Heindel, Walter; Pfleiderer, Bettina

doi:10.1097/00001756-200403010-00033

Cited by 64 publications

(58 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It is of note that elevated homocysteine levels have been associated with better short-and long-term verbal memory performance in females with anorexia nervosa and bulimia nervosa [15] . A significant reduction in glutamate/glutamine levels has also been observed in anorectic patients [43] .…”

Section: Discussionmentioning

confidence: 85%

Homocysteine and Cognitive Function in Geriatric Depression

et al. 2010

View full text Add to dashboard Cite

Background/Objectives: Cognitive dysfunction is a common aspect of the spectrum of symptoms of geriatric depression. High homocysteine levels have been linked to cognitive decline in neuropsychiatric disorders. The present study investigated possible associations between cognitive impairment observed in geriatric depression and homocysteine levels. Methods: The performance of 25 mentally healthy individuals and 40 patients with geriatric depression in terms of language processing, processing speed, concentration and attention was assessed with the Stroop Test and the d2 Test of Attention. Serum homocysteine was determined with an enzyme immunoassay. Results: The performance of depressed patients was significantly worse in language processing (p = 0.001) and processing speed (p < 0.0001). Depressed patients with high levels of homocysteine performed better than patients with homocysteine concentrations ≤11.7 µmol/l in both cognitive domains (p = 0.006 and 0.009, respectively). Moreover, homocysteine level was positively associated with language processing (p = 0.002) and processing speed (p = 0.002). Conclusions: These findings indicate that under the special circumstances of geriatric depression (perturbation of glutamatergic transmission and glutamate metabolism), homocysteine is positively associated with the performance in language processing and processing speed.

show abstract

Section: Discussionmentioning

confidence: 85%

Homocysteine and Cognitive Function in Geriatric Depression

et al. 2010

View full text Add to dashboard Cite

show abstract

“…50) These changes may be related to decline of cognitive functioning. 51) There are reports that impairment of memory-related behavior and reduced anxiety behavior results from PM in rats. 12,[20][21][22] We have also previously reported alterations in cognitive function in PM mice.…”

Section: Discussionmentioning

confidence: 99%

Executive Functions of Postweaning Protein Malnutrition in Mice

Sato

Nakagawasai

Tan-No

et al. 2011

Biological & Pharmaceutical Bulletin

View full text Add to dashboard Cite

An inadequate supply of nutrition is one of the main nongenetic factors affecting brain development.1) Liu et al. 2) demonstrated that children with malnutrition signs at three years of age tend to have low IQ, excessive motor activity and antisocial behavior in adulthood. In the framework of such nutritional inadequacy, early protein malnutrition (PM) adversely affects central nervous system (CNS) maturation, resulting in long-lasting, or even permanent, deleterious effects. 3,4)Malnutrition is a common problem worldwide and occurs in both developing and developed countries. In developing countries malnutrition is associated with poverty or socioeconomic problems, whereas in developed countries, the weight of the newborn is influenced by the mothers diet 5) and the weight at birth affects subsequent development. 6) Also, in developed countries, severe malnutrition is commonly found in patients with eating disorders which frequently occurs during adolescence leading to interruptions of somatic and psychological development. The use of common weight control techniques by healthy weight adolescents can produce chronic undernutrition. 7)In rats, there are two principal types of PM experimental models: prenatal (i.e., gestation period) and early postnatal (i.e., lactation period) malnutrition. There are many studies focused on body and brain morphological affects of these PM models, such as body and brain weight, 3) hippocampal effects, 8,9) span of basilar dendrities 10) and neocortical effects.11) The prenatal and early postnatal PM also causes various abnormal behaviors, such as increased exploratory behavior, 12,13) reduced anxiety, 13,14) decreased social interaction, 15) increased depressive behavior, 16) increased aggressive behavior, 17,18) prepulse inhibition deficits 19) and impairment of memory-related behavior. [20][21][22] In contrast, there are remarkably few reports concerning postweaning PM effects on the CNS. Lukoyanov and Andrade 23) found that eight months of PM in adult rats induced a marked loss of neurons and synapses in the hippocampal formation and that the morphological alterations led to noticeable impairments in openfield behavior and spatial learning in the water maze. Thus, even if PM begins in adult animals, abnormal behaviors are induced which take a long time to express.The human brain develops rapidly in the last third of pregnancy and the first two years of life. Brain weight increases with age and achieves adult weight between six and 14 years of age. By two years of age the brain is approximately 80% of the adult weight and at one time it was believed that, to a large extent, brain development had ended. More recently it has become apparent that brain development continues through adolescence and even as adults the brain can adapt to changing circumstances. Adolescence is a particularly important time for brain development as more adult ways of thinking emerge: abstract thinking, deductive reasoning and the ability to solve problems. 24) There is increasing evidence that diet...

show abstract

“…A recent 1 H-MRS study of 11 unmedicated female AN patients reported reduced dorsolateral prefrontal cortex myo-inositol relative to healthy controls, inversely correlating this reduction with duration of illness (Ohrmann et al, 2004). In an earlier 1 H-MRS study of 20 patients with AN or BN, reduced frontal white matter myo-inositol concentrations were found in patients compared with healthy controls, with those patients with the lowest body mass index having the greatest reductions (Roser et al, 1999).…”

Section: Eating Disordersmentioning

confidence: 92%

A review of the possible relevance of inositol and the phosphatidylinositol second messenger system (PI‐cycle) to psychiatric disorders—focus on magnetic resonance spectroscopy (MRS) studies

Kim

McGrath

Silverstone

2005

Human Psychopharmacology

119

View full text Add to dashboard Cite

Myo-inositol is an important part of the phosphatidylinositol second messenger system (PI-cycle). Abnormalities in nerve cell myo-inositol levels and/or PI-cycle regulation has been suggested as being involved in the pathophysiology and/or treatment of many psychiatric disorders including bipolar disorder, major depressive disorder, panic disorder, obsessive-compulsive disorder, eating disorders and schizophrenia. This review examines the metabolism and biochemical importance of myo-inositol and the PI-cycle. It relates this to the current in vivo evidence for myo-inositol and PI-cycle involvement in these psychiatric disorders, particularly focusing upon the magnetic resonance spectroscopy (MRS) findings in patient studies to date. From this review it is concluded that while the evidence suggests probable relevance to the pathophysiology and/or treatment of bipolar disorder, there is much less support for a significant role for the PI-cycle or myo-inositol in any other psychiatric disorder. More definitive investigation is required before PI-cycle dysfunction can be considered specific to bipolar disorder.

show abstract

Proton magnetic resonance spectroscopy in anorexia nervosa: correlations with cognition

Cited by 64 publications

References 21 publications

Homocysteine and Cognitive Function in Geriatric Depression

Homocysteine and Cognitive Function in Geriatric Depression

Executive Functions of Postweaning Protein Malnutrition in Mice

A review of the possible relevance of inositol and the phosphatidylinositol second messenger system (PI‐cycle) to psychiatric disorders—focus on magnetic resonance spectroscopy (MRS) studies

Contact Info

Product

Resources

About