Proton magnetic resonance spectroscopy of late delayed radiation-induced injury of the brain

Chan, Y. L.; Yeung, David W. K.; Leung, Sing Fai; Cao, Guang

doi:10.1002/(sici)1522-2586(199908)10:2<130::aid-jmri4>3.0.co;2-r

Cited by 84 publications

(53 citation statements)

References 29 publications

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“…To reduce the systematic variations among the animals studied and to extract the dominating metabolic changes, metabolite ratios were used in this study. The tCr concentration was used as a normalising factor since its concentration in normal brain is relatively constant, which is reported in earlier studies 13,20 . Earlier MRS studies have also observed no change in the concentration of creatine during acute or delayed response of radiation exposure 21,22 .…”

Section: Resultsmentioning

confidence: 99%

“…There are several proton MRS based studies available in the literature that report radiation induced metabolic impairment in brain but these studies are limited to fractionated or focal radiation exposure [11][12][13][14][15][16][17] . In the present study, to further extend the prospects of MRS in whole body radiation exposure scenario and to understand the differential effect of varied radiation doses in brain, in vivo proton MRS has been used to look for early metabolic changes after whole body exposure to different doses of radiation in mice.…”

Section: Introductionmentioning

confidence: 99%

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Early Differential Neurometabolite Response of Hippocampus on Exposure to Graded dose of Whole Body Radiation: An in Vivo 1H MR Spectroscopy Study

et al. 2017

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Whole body radiation exposure induced injury may occur during medical or industrial accidents as well as during terrorist radiation exposure scenario. A lot of information is available on alterations in brain function and metabolism post localised cranial irradiation; changes in brain associated with whole body radiation exposure are still limited. The present study has been conducted to assess early differential effect of low and high whole body radiation exposure on hippocampus neurometabolites using in vivo proton magnetic resonance spectroscopy ( 1 H MRS). Hippocampal 1 H MRS was carried out in controls (n = 6) and irradiated mice exposed to 3 Gy, 5 Gy, and 8 Gy of radiation (n = 6 in each group) at different time points i.e., day 0, 1, 3, 5 and 10 post irradiation at 7 T MRI system. Quantitative assessment of the neurometabolites was done using LCModel. The results revealed significant decrease in myoionisitol (mI)/creatine (tCr) and taurine (tau)/tCr in animals exposed to 5 Gy and 8 Gy dose compared to controls. In 3 Gy dose group, none of the metabolites showed significant alterations at any of the time point post irradiation as compared to controls. Overall our findings suggest differential change in hippocampal volume regulatory mechanism associated neuro-metabolites following whole body radiation exposure with maximum reduction in case of high dose group. We speculate that these alterations may be a consequence of oxidative stress, neuro inflammation or systemic inflammatory response following whole body radiation exposure.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Early Differential Neurometabolite Response of Hippocampus on Exposure to Graded dose of Whole Body Radiation: An in Vivo 1H MR Spectroscopy Study

et al. 2017

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“…(5,19,22) Using MRI images to study 1H-MRS, authors report that based on some metabolites and metabolite ratios evaluation, it is possible to differentiate between BM recurrence and radionecrosis. (3,8) However pathological specimens still remain the gold standard for distinguishing tumor from necrosis, because non of the imaging modalities is possible to reliably differentiate necrosis from progression in 100% of the cases. (20) Since currently one can not reliably make differentiation between tumor progression and radiation effect noninvasively, delayed neurosurgical resection does need to be considered for patients with symptomatic progression of intracerebral lesion after GKS.…”

Section: Methodsmentioning

confidence: 99%

Diagnostic Pitfalls of Brain Metastases After Brain Irradiation

Peev¹

2010

JofIMAB

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Although brain metastases are one of the most frequently diagnosed sequelae of systemic malignancy, their optimal management still is not well defined. In that respect the different diagnostic and therapeutic approaches of BMs patients is an issue for serious discussions. Among the most commonly used diagnostic tools are computed tomography (CT) scans, magnetic resonance imaging (MRI) scans, single photon emission computed tomography (SPECT) and positron emission tomography (PET) scans etc. Nowadays the aforementioned diagnostic modalities are usually combined in order to obtain complete diagnostic information important for establishing the optimal treatment.With the present report we try to elaborate on the value of the modern diagnostic tools in differentiating between tumor progression versus radiation necrosis in irradiated patients with resected brain metastases.Although the present advancement of the modern imaging modalities differentiating between tumor progression versus radiation necrosis is often difficult. Application of the metabolic imaging modalities like SPECT, PET and proton magnetic resonance spectroscopy (1H-MRS) contributes for the diagnose but still pathological specimens remain a gold standard for distinguishing tumor from necrosis, because none of the imaging modalities is possible to reliably differentiate necrosis from progression in 100% of the cases.

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“…), there is now a generally recognized 'normal' spectral pattern for both short-echotime and long-echo-time spectra. Departures from these normal brain spectral patterns are readily discerned by the eye for some pathologies like tumors, in which the Cho resonance generally dominates [102][103][104][105].…”

Section: Proton Mrsmentioning

confidence: 99%

“…The increased Cho signal from tumor is generally useful when there is some question as to the nature of a non-contrast-agent-enhancing signal abnormality such as may be associated with a low-grade tumor, when identifying residual tumor in general and, in particular, when differentiating radiation-induced treatment changes from recurrent tumor [104,105]. In such cases, the multi-voxel approach is preferred over single-voxel approaches since choosing where to place the single voxel from imaging characteristics alone may be difficult.…”

Section: Proton Mrsmentioning

confidence: 99%

Magnetic resonance and the human brain: anatomy, function and metabolism

Talos

Mian

Zou

et al. 2006

Cell. Mol. Life Sci.

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The introduction and development, over the last three decades, of magnetic resonance (MR) imaging and MR spectroscopy technology for in vivo studies of the human brain represents a truly remarkable achievement, with enormous scientific and clinical ramifications. These effectively non-invasive techniques allow for studies of the anatomy, the function and the metabolism of the living human brain. They have allowed for new understandings of how the healthy brain works and have provided insights into the mechanisms underlying multiple disease processes which affect the brain. Different MR techniques have been developed for studying anatomy, function and metabolism. The primary focus of this review is to describe these different methodologies and to briefly review how they are being employed to more fully appreciate the intricacies associated with the organ, which most distinctly differentiates the human species from the other animal forms on earth.

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Proton magnetic resonance spectroscopy of late delayed radiation-induced injury of the brain

Cited by 84 publications

References 29 publications

Early Differential Neurometabolite Response of Hippocampus on Exposure to Graded dose of Whole Body Radiation: An in Vivo 1H MR Spectroscopy Study

Early Differential Neurometabolite Response of Hippocampus on Exposure to Graded dose of Whole Body Radiation: An in Vivo 1H MR Spectroscopy Study

Diagnostic Pitfalls of Brain Metastases After Brain Irradiation

Magnetic resonance and the human brain: anatomy, function and metabolism

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