To study the quenching of single-particle strengths of carbon isotopes, a systematic analysis is made for 9−12,14−20C, with single neutron knockout reactions on Be/C targets, within an energy range from around 43 to 2100 MeV/nucleon, using the Glauber model. Incident energies do not show obvious effect on the resulting values across this wide energy range. The extracted quenching factors are found to be strongly dependent on the proton–neutron asymmetry, which is consistent with the recent analysis of knockout reactions but is different from the systematics of transfer and quasi-free knockout reactions. Quenching of single-paricle strengths of carbon isotopes 9−12,14−20C with knockout reactions for incident energies 43-2100 MeV/nucleon.