Proton Pump Inhibitor-Associated Large Hyperplastic Polyp in Non-<b><i>Helicobacter pylori</i></b>-Infected Stomach

Abstract

A proton pump inhibitor (PPI)-associated hyperplastic polyp (HP) in the non-&lt;i&gt;Helicobacter pylori&lt;/i&gt;-infected stomach is rare, and its endoscopic features remain poorly described. A 42-year-old man with tarry stool was referred to our hospital for examination and treatment. He had taken PPI for 14 years and was confirmed to be &lt;i&gt;H. pylori&lt;/i&gt;-negative. Transnasal endoscopy revealed bleeding from a 20-mm, reddish pedunculated polyp with a nodular surface, located in the greater curvature of the upper gastric body. Endoscopic mucosal resection was performed, and the lesion was diagnosed as an HP. To our knowledge, this report represents a valuable addition to the HP literature describing a rare case of PPI-associated large HP in the non-&lt;i&gt;H. pylori&lt;/i&gt;-infected stomach.

Severe Anemia from Multiple Gastric Hyperplastic Polyps in a Hemodialysis Patient after Long-term Use of a Proton-pump Inhibitor

“…Most likely, long-term use of a proton-pump inhibitor promotes hyperplastic polyp formation, particularly in gastric mucosa with chronic injury. Similar to our case, there were multiple cases where proton-pump inhibitor-related hyperplastic polyps were detected in gastric mucosa without H. pylori infection ( 28 , 44 , 45 ). Further research is necessary to identify risk factors for hyperplastic polyp formation.…”