Proton pump inhibitor prescribing patterns in the UK: a primary care database study

Abstract

 The prevalence of PPI use in the UK general population is high and still increasing. The majority of patients only use PPIs short term, with only 26% using them longterm. Clear attempts to step down long-term use were identified in two fifths of the patients, so there remain further opportunities for reducing the cost and side effects of PPI use through improving adherence to recommended withdrawal strategies.

Do FDA label changes work? Assessment of the 2010 class label change for proton pump inhibitors using the Sentinel System's analytic tools

“…For example, we found the proportion of female users was 58.1% to 58.4%, which is similar to the 55.9% described in a recent UK Clinical Practice Research Database study 18 and the 55.0% in a regional study of elderly Swedes. 25 The general increase in PPI prescriptions was also observed in previous research from the United Kingdom, 18 the United States, 26 and Australia. 27 The apparent decrease in OP screening/interventions and lack of appreciable change in high-dose PPI use were counter to our hypothesis that these would have increased and decreased, respectively, had the label change been effective.…”

“…While few others have assessed the impact of label changes on prescriber behaviors, our descriptive findings compare other research that has evaluated PPI prescription patterns and demographics both in the United States and elsewhere. For example, we found the proportion of female users was 58.1% to 58.4%, which is similar to the 55.9% described in a recent UK Clinical Practice Research Database study and the 55.0% in a regional study of elderly Swedes . The general increase in PPI prescriptions was also observed in previous research from the United Kingdom, the United States, and Australia …”

“…Prevalent use was defined as any PPI use at the time of outcome assessment, whereas incident users could not have had a PPI prescription in the 183 days before the incident dispensing. Consistent with the FDA label change and previous research on the incidence of fractures, long‐term usage was defined as a PPI episode of 1 year or more. Dosage was defined using the NDCs that represented the lower vs higher dose strength for each individual PPI.…”

Snapshot of proton pump inhibitors prescriptions in a tertiary care hospital in Switzerland: less is more?

“…A database study from 2016 demonstrates that the PPI use in UK general practices increased between 1990 and 2014 and that 60% of long-term users did not attempt to discontinue or step down the dose [32]. These data suggest that the re-evaluation of the adequacy of the PPI treatment was not done although patients should benefit from a reconsideration of the usefulness of their treatment on a regular basis.…”

Long‐term use of proton pump inhibitors, dose–response relationship and associated risk of ischemic stroke and myocardial infarction

“…drugs worldwide [1][2][3][4]. A number of studies have suggested, however, that many patients are prescribed PPIs inappropriately [5][6][7][8].…”