Proton pump inhibitor-related headaches: A nationwide population-based case-crossover study in Taiwan

Liang, Jen Feng; Chen, Yung Tai; Fuh, Jong Ling; Li, Szu Yuan; Chen, Tzeng Ji; Tang, Chao Hsiun; Wang, Shuu Jiun

doi:10.1177/0333102414535114

Cited by 18 publications

(10 citation statements)

References 40 publications

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“…The headache association was confirmed in a crossover study conducted in Taiwan where lansoprazole and esomeprazole use increased headache incidence (OR, 1.20, 95% CI, [1.07,1.35], P < 0.002) 44 . However, according to our findings the headache effect may be common to both treatment classes, since there was no significant difference in headache reports between PPI and H2RA cohorts.…”

Section: Discussionmentioning

confidence: 78%

Proton-pump inhibitor use is associated with a broad spectrum of neurological adverse events including impaired hearing, vision, and memory

Makunts

Alpatty

Lee

et al. 2019

Sci Rep

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Proton-pump inhibitors, PPIs, are considered effective therapy for stomach acid suppression due to their irreversible inhibition of the hydrogen/potassium pump in the gastric parietal cells. They are widely prescribed and are considered safe for over-the-counter use. Recent studies have shown an association between PPI use and Alzheimer dementia, while others have disputed that connection. We analyzed over ten million United States Food and Drug Administration Adverse Event Reporting System reports, including over forty thousand reports containing PPIs, and provided evidence of increased propensity for memory impairment among PPI reports when compared to histamine-2 receptor antagonist control group. Furthermore, we found significant associations of PPI use with a wide range of neurological adverse reactions including, migraine, several peripheral neuropathies, and visual and auditory neurosensory abnormalities.

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Section: Discussionmentioning

confidence: 78%

Proton-pump inhibitor use is associated with a broad spectrum of neurological adverse events including impaired hearing, vision, and memory

Makunts

Alpatty

Lee

et al. 2019

Sci Rep

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“…Data of all situational factors were organized and analyzed. To account for such pairing, conditional logistic regression, a standard method for the case-crossover design [ 13 , 14 ], was used to assess the significance of the associations between the studied event-specific risk factors and occurrence of UAI. Matched odds ratios (OR) and their 95% confidence intervals (CI) were presented.…”

Section: Methodsmentioning

confidence: 99%

“…The matched (conditional) logistic regression method is a standard method to analyze such data. In our case, a pair of episodes of UAI and PAI of the same individual is used as unit of analysis [ 13 , 14 ]. Hence, it allows researchers to investigate various event-specific risk factors to distinguish episodes of UAI from episodes of PAI.…”

Section: Introductionmentioning

confidence: 99%

Event-Specific Risk Factors Predicting Episodes of Unprotected Anal Intercourse with Male Nonregular Partners among Men Who Have Sex with Men Using Case-Crossover Study Design

Lau

et al. 2014

BioMed Research International

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This study investigated event-specific factors that determine episodes of unprotected and protected anal intercourse (UAI and PAI) among 215 men who have sex with men (MSM), who used condoms inconsistently with nonregular partners (NRP) in the last six months, in Hong Kong. A case-crossover study design was used. Lower likelihood of episodes involving UAI with NRP was associated with (1) five partner attributes (NRP were <35 years old, at least three previous anal sex experiences with the NRP, perception that participant and the NRP had asymmetrical sexual experience, perception that the NRP was feminine, and liking toward the NRP; OR = 0.16–0.52), (2) six situational variables (the participant having had UAI with another man in the last week, having discussed condom use, perception that the NRP liked to use condom, partner's suggestion to have PAI, participant's suggestion to have PAI, and participant's plan to use condoms; OR = 0.11–0.39), and (3) four environmental/setting variables (condoms already placed at the venue, display of condom use promotion materials, participant's possession of a condom, and the NRP possessed a condom; OR = 0.27–0.45). HIV prevention targeting MSM should focus on event-specific protective factors, which may be different from those obtained from studies distinguishing condom users versus nonusers.

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“…Some PPIs, such as lansoprazole, esomeprazole, and pantoprazole, are reported to cause adverse neurological effects, mainly headaches [ 30 , 31 ] and dizziness/vertigo [ 32 ]. Other adverse effects that involve the CNS (at a frequency of <1%) include depression, diplopia, disturbed sleep, drowsiness, insomnia, nervousness, and tremor.…”

Section: The Effect Of Ppis On the Central Nervous Systemmentioning

confidence: 99%

Proton Pump Inhibitors and Dementia: Physiopathological Mechanisms and Clinical Consequences

et al. 2018

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Alzheimer's disease (AD) is the most common type of dementia, mainly encompassing cognitive decline in subjects aged ≥65 years. Further, AD is characterized by selective synaptic and neuronal degeneration, vascular dysfunction, and two histopathological features: extracellular amyloid plaques composed of amyloid beta peptide (Aβ) and neurofibrillary tangles formed by hyperphosphorylated tau protein. Dementia and AD are chronic neurodegenerative conditions with a complex physiopathology involving both genetic and environmental factors. Recent clinical studies have shown that proton pump inhibitors (PPIs) are associated with risk of dementia, including AD. However, a recent case-control study reported decreased risk of dementia. PPIs are a widely indicated class of drugs for gastric acid-related disorders, although most older adult users are not treated for the correct indication. Although neurological side effects secondary to PPIs are rare, several preclinical reports indicate that PPIs might increase Aβ levels, interact with tau protein, and affect the neuronal microenvironment through several mechanisms. Considering the controversy between PPI use and dementia risk, as well as both cognitive and neuroprotective effects, the aim of this review is to examine the relationship between PPI use and brain effects from a neurobiological and clinical perspective.

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Proton pump inhibitor-related headaches: A nationwide population-based case-crossover study in Taiwan

Abstract: PPI usage is associated with an increased risk for acute headache. Female patients and use of lansoprazole or esomeprazole present the greatest risks of headache.

Cited by 18 publications

References 40 publications

Proton-pump inhibitor use is associated with a broad spectrum of neurological adverse events including impaired hearing, vision, and memory

Proton-pump inhibitor use is associated with a broad spectrum of neurological adverse events including impaired hearing, vision, and memory

Event-Specific Risk Factors Predicting Episodes of Unprotected Anal Intercourse with Male Nonregular Partners among Men Who Have Sex with Men Using Case-Crossover Study Design

Proton Pump Inhibitors and Dementia: Physiopathological Mechanisms and Clinical Consequences

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