Proton-Pump Inhibitors and Outcome of Endoscopic Hemostasis in Bleeding Peptic Ulcers: A Series of Metaanalyses

Andriulli, Angelo; Annese, Vito; Caruso, N.; Pilotto, Alberto; Accadia, L.; Niro, Grazia; Quitadamo, M.; Merla, Antonio; Fiorella, Serafina; Leandro, Gioacchino

doi:10.1111/j.1572-0241.2005.40636.x

Cited by 85 publications

(64 citation statements)

References 40 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Several prospective controlled studies and Values are mean ± SD Group I, patients treated with soft coagulation; Group II, patients treated with hemoclips; NSAIDs, nonsteroidal anti-inflammatory drugs meta-analyses have demonstrated the efficacy of endoscopic hemostasis [18][19][20][21][22][23][24][25][26][27][28][29][30][31][32]. In these studies, endoscopic hemostasis was performed with local injection therapy, thermal coagulation therapy or mechanical hemostatic methods such as clipping, and there were few statistical differences between these procedures with regard to the hemostatic rate (ranging from 70.0 to 98.5%).…”

Section: Discussionmentioning

confidence: 99%

Evaluation of hemostasis with soft coagulation using endoscopic hemostatic forceps in comparison with metallic hemoclips for bleeding gastric ulcers: a prospective, randomized trial

Arima

Sakata

Ogata³

et al. 2009

J Gastroenterol

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 99%

Evaluation of hemostasis with soft coagulation using endoscopic hemostatic forceps in comparison with metallic hemoclips for bleeding gastric ulcers: a prospective, randomized trial

Arima

Sakata

Ogata³

et al. 2009

J Gastroenterol

View full text Add to dashboard Cite

show abstract

“…Adjuvant PPI therapy, administered following diagnostic and/or therapeutic EGD, has been proven effective, as well, leading to a decrease in recurrent PUD bleeding, need for blood transfusion, need for surgery, and duration of hospital stay [3,18,19] . Despite these major impacts, studies have not demonstrated an impact of PPIs on mortality due to UGIH [3,20,21] . Furthermore, whether in the neoadjuvant or adjuvant setting, the optimal dosing, route of administration, and duration of post-endoscopy PPI has not been clearly established.…”

Section: Pharmacologic Therapy Prior To Endoscopymentioning

confidence: 99%

Management of non-variceal upper gastrointestinal tract hemorrhage: Controversies and areas of uncertainty

Trawick

Yachimski²

2012

WJG

View full text Add to dashboard Cite

Upper gastrointestinal tract hemorrhage (UGIH) remains a common presentation requiring urgent evaluation and treatment. Accurate assessment, appropriate intervention and apt clinical skills are needed for proper management from time of presentation to discharge. The advent of pharmacologic acid suppression, endoscopic hemostatic techniques, and recognition of Helicobacter pylori as an etiologic agent in peptic ulcer disease (PU�) has revolutionized the treatment of UGIH. �espite this, acute UGIH still carries considerable rates of morbidity and mortality. This review aims to discuss current areas of uncertainty and controversy in the management of UGIH. Neoadjuvant proton pump inhibitor (PPI) therapy has become standard empiric treatment for UGIH given that PU� is the leading cause of non-variceal UGIH, and PPIs are extremely effective at promoting ulcer healing. However, neoadjuvant PPI administration has not been shown to affect hard clinical outcomes such as rebleeding or mortality. The optimal timing of upper endoscopy in UGIH is often debated. Upon completion of volume resuscitation and hemodynamic stabilization, upper endoscopy should be performed within 24 h in all patients with evidence of UGIH for both diagnostic and therapeutic purposes. With rising healthcare cost paramount in today's medical landscape, the ability to appropriately triage UGIH patients is of increasing value. Upper endoscopy in conjunction with the clinical scenario allows for accurate decision making concerning early discharge home in low-risk lesions or admission for further monitoring and treatment in higher-risk lesions. Concomitant pharmacotherapy with non-steroidal anti-inflammatory drugs (NSAI�s) and antiplatelet agents, such as clopidogrel, has a major impact on the etiology, severity, and potential treatment of UGIH. Long-term PPI use in patients taking chronic NSAI�s or clopidogrel is discussed thoroughly in this review.

show abstract

“…Plusieurs études ont constaté qu'une grande proportion des décès surviennent chez des patients présentant une comorbidité sévère, chez qui, l'hémorragie, même mineure, est mal tolérée [39][40][41][42][43].…”

Section: Discussionunclassified

Épidémiologie des hémorragies digestives hautes en Tunisie

et al. 2010

View full text Add to dashboard Cite

L'hémorragie digestive haute demeure une cause fréquente d'hospitalisation, de morbidité et de mortalité. Les études épidémiologiques sont limitées dans notre pays. But : Déterminer les causes et l'évolution des patients ayant une hémorragie digestive haute, colligés au CHU de Monastir. Matériels et méthodes : Les dossiers de 874 patients qui ont subi une endoscopie digestive haute pour hémorragie digestive pendant une durée de dix ans (1997)(1998)(1999)(2000)(2001)(2002)(2003)(2004)(2005)(2006)(2007) ont été rétro-spectivement analysés. Résultats : Les hémorragies digestives hautes ont représenté 5,3 % de l'ensemble des endoscopies digestives hautes. On avait noté une nette prédominance masculine (63,1 %), avec un âge moyen de 54 ± 12 ans. L'origine de saignement a été détectée dans 90 % des cas. La précision diagnostique était plus grande quand l'endoscopie est pratiquée dans les 24 premières heures suivant l'apparition de l'hémorragie, et en présence de l'hématémèse. L'ulcère gastroduodénal est la cause la plus fréquente de l'hémorragie digestive haute (50,5 %), suivi des gastroduodénites hémorragiques (24 %). La prévalence de l'hémorragie digestive par rupture des varices oesogastriques était de 9,49 %. Le traitement endoscopique a été utilisé dans 103 cas (11,7 %). Une intervention chirurgicale a été effectuée chez 51 patients (5,83 %), incluant 9,9 % des patients ayant un ulcère hémor-ragique. Trente-six patients étaient décédés (4,1 %). Conclusion : L'ulcère hémorragique est la cause la plus fré-quente d'hémorragie digestive dans notre pays. La mortalité était élevée dans le groupe des patients ayant saigné par rupture des varices oesogastriques. La plupart des cas d'hémor-ragie digestive haute peuvent être traités par hémostase endoscopique, quand l'endoscopie diagnostique établit la source. Mots clésHémorragie digestive haute · Ulcère gastroduodénal · Gastroduodénite hémorragique · Endoscopie Abstract Background: Acute upper gastrointestinal bleeding (UGIB) continues to be a common cause of hospital admission and morbidity and mortality. Epidemiological studies are still limited in our country. Aim and objectives: The aim of this study is to determine the causes and outcome of patients with UGIB presenting at the teaching hospital of Monastir. Materials and methods: The study was carried out at the teaching hospital of Monastir. The records of 874 patients who underwent endoscopy for UGIB over a period of 10 years (1997)(1998)(1999)(2000)(2001)(2002)(2003)(2004)(2005)(2006)(2007) were retrospectively analysed. Results: The acute UGIB represented 5.3% of all high digestive endoscopy. Male predominance (63.1%) was noted with an average age of 54 ± 12 years. A bleeding site could be detected in 75.6% of the patients. Diagnostic accuracy was greater within the first 24 hours of the bleeding onset and in the presence of hematemesis. Peptic ulcer was the main cause of UGIB (50.5%) followed by erosive mucosal disease (24%). The prevalence of variceal bleeding was 9.49%. Endoscopic treatment was used in 103 case...

show abstract

Proton-Pump Inhibitors and Outcome of Endoscopic Hemostasis in Bleeding Peptic Ulcers: A Series of Metaanalyses

Cited by 85 publications

References 40 publications

Evaluation of hemostasis with soft coagulation using endoscopic hemostatic forceps in comparison with metallic hemoclips for bleeding gastric ulcers: a prospective, randomized trial

Evaluation of hemostasis with soft coagulation using endoscopic hemostatic forceps in comparison with metallic hemoclips for bleeding gastric ulcers: a prospective, randomized trial

Management of non-variceal upper gastrointestinal tract hemorrhage: Controversies and areas of uncertainty

Épidémiologie des hémorragies digestives hautes en Tunisie

Contact Info

Product

Resources

About