Proton pump inhibitors: are they safe on kidneys: a histopathological study

Limaye, Ramachandra Prabhakar; Pendhari, Shabbir Rafik; Joshi, Kedar

doi:10.18203/2319-2003.ijbcp20162220

Cited by 2 publications

(2 citation statements)

References 7 publications

(17 reference statements)

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“…Esomeprazole is manufactured by AstraZeneca, (Egypt) in the form of sachet containing 10 mg. Each sachet was dissolved in 10 ml distilled water then 5mg/kg (1ml of the prepared solution), was given orally by an intragastric tube once daily for 4 weeks [18,19] .…”

Section: Drugsmentioning

confidence: 99%

Histological study of the effect of proton pump inhibitor (esomeprazole) on the renal cortex of adult male albino rats.

Salib

Kandeel

El-Mehey

et al. 2019

Egyptian Journal of Histology

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Background: Esomeprazole is one of the proton pump inhibitors used in the treatment of gastrointestinal disorders. In spite of its safety, it can induce many side effects, especially acute interstitial nephritis that may progress into acute renal failure. Aim: This work aimed to investigate the effect of proton pump inhibitor (esomeprazole) on the histological structure of the renal cortex of adult male albino rats, as well as the effect of stoppage of that exposure. Materials and methods: 30 adult male albino rats were divided into three groups (10 rats each); control, esomeprazole group: rats received 5 mg/kg/day esomeprazole orally for 4weeks, and recovery group by which rats received esomeprazole 5 mg/kg /day orally, then left for another 4 weeks without treatment. After that, the renal cortex obtained and processed for light and transmission electron microscopic examination. Results: Esomeprazole group showed shrunken glomeruli with widening of Bowman's space, vacuolated glomerular and tubular cells, with darkly stained nuclei, focal interruption of PAS reaction in the brush border of PCTs besides statistically significant decrease in the mean optical density for PAS when compared with control, and focal ultrastructural changes in renal corpuscles, proximal and distal convoluted tubules. In recovery group; partial improvement of the previous histopathological findings observed. Conclusion: Esomeprazole induced histopathological changes in the structure of the renal cortex of adult male albino rats, which could be partially improved if left to recover.

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Section: Drugsmentioning

confidence: 99%

Histological study of the effect of proton pump inhibitor (esomeprazole) on the renal cortex of adult male albino rats.

Salib

Kandeel

El-Mehey

et al. 2019

Egyptian Journal of Histology

View full text Add to dashboard Cite

show abstract

“…This is similar to the study of Tamilselvan et al and Santraet al 12 Our earlier experimental study had postulated a possible connection between use of PPI and AIN. 18 Based on such similar studies and other reports FDA has included this statement in his latest report in view of this information extensive use of PPI in dialysis patients is a potential problem in the nephrology unit. Multicentric as well as continuous follow-up studies might be needed before conclusive guidelines for contraindications are formed.…”

Section: Discussionmentioning

confidence: 87%

Use of proton pump inhibitors in dialysis unit in tertiary care hospital: a pharmaco-epidemiological study

Pendhari¹,

Joshi²,

Limaye³

2021

Int J Basic Clin Pharmacol

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Background: Proton pump inhibitors (PPI) are generally thought to be safer drug with fewer adverse effects. Though this class of the drug is thought to be well tolerated, a detail study about actual use of these agents in nephrology department is still awaited in many parts of India. There had been case reports and case series which were reporting PPIs producing acute interstitial nephritis progressing to acute renal failure. The risk of PPI treatment in haemodialysis patients remains unexplored. The aim of the study was to evaluate a drug utilization of PPI in patient undergoing haemodialysis procedure.Methods: In this study every day visit to the dialysis units of the hospitals was carried out. After taking consent from the patients, the information from the case-report form was noted like; age, sex, diagnosis, laboratory reports and drug prescried. No personally identifiable information about patient or physician was collected. After this an interview of patients was taken.Results: In this study, out of 126 patients 76.6% were male and 23.4% were female. Out of these 126 patients 88.89% patients were on PPI. Nearly 54% were using PPI for more than six months. Nearly 29% patients were using PPI for more than 12 months.Conclusions: As many case-reports and studies are suggesting, there is co-relation of PPI and acute interstitial nephritis from this study we suggest that especially in nephrology unit patients’, more caution must be exercised while using PPI.

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Proton pump inhibitors: are they safe on kidneys: a histopathological study

Cited by 2 publications

References 7 publications

Histological study of the effect of proton pump inhibitor (esomeprazole) on the renal cortex of adult male albino rats.

Histological study of the effect of proton pump inhibitor (esomeprazole) on the renal cortex of adult male albino rats.

Use of proton pump inhibitors in dialysis unit in tertiary care hospital: a pharmaco-epidemiological study

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