Proton Pump Inhibitors for Stress Ulcer Bleeding Prophylaxis in Critically Ill Patients: A Cost Analysis Study

Abstract

Objective: Stress ulcer prophylaxis is generally administered for the prevention stress-related mucosal disease (SRMD) in critically ill patients. Proton pump inhibitors (PPIs) are most commonly prescribed in preventing bleeding from SRMD. Pantoprazole intravenous (iv) and omeprazole iv are the most effective, but clinically effective is not always efficient. This study aimed to investigate whether the most efficient PPIs for prophylaxis in intensive care unit settings.Methods: An observational study was conducted on June 2014 with comparative design by using medical records in January 2012-November 2014 in a private hospital in Bandung city. Both retrospective and prospective data collection was performed in this study. Paired t-test analysis was used to compare average cost of the drugs with significant level p<0.05. Results:The results showed the average cost of pantoprazole iv 458.142 Indonesian Rupiah (IDR)/patient and omeprazole iv 575.573 IDR/patient; there were significant differences of average drug cost between pantoprazole iv and omeprazole iv (p=0.0085). Conclusion:Both pantoprazole iv and omeprazole iv were effective, but pantoprazole iv had been found more efficient.