Proton Pumps: Molecular Mechanisms, Inhibitors and Activators of Proton Pumping

Siletsky, Sergey A.

doi:10.3390/ijms24109070

Cited by 2 publications

(2 citation statements)

References 7 publications

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“…While a definitive cure does not exist, dietary adjustments and DAO enzyme supplements help to manage symptoms and improve the quality of life for those with HIT or DAO deficiency [18]. In addition, DAO interactions with pharmaceutical drugs are crucial considerations in managing histaminerelated conditions like fibromyalgia [19]; certain pharmaceutical drugs, like proton pump inhibitors (PPIs) [20] and non-steroidal anti-inflammatory drugs (NSAIDs) [21], have been reported to potentially inhibit DAO activity, impacting individuals with HIT and necessitating awareness of medication interactions [20,22]. This inhibition may contribute to histamine-intolerance-related symptoms, potentially impacting individuals with fibromyalgia.…”

Section: Introductionmentioning

confidence: 99%

Exploring the Relationship between Diamine Oxidase and Psychotropic Medications in Fibromyalgia Treatment, Finding No Reduction in Diamine Oxidase Levels and Activity except with Citalopram

Tobajas,

Alemany-Fornés,

Samarra

et al. 2024

JCM

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Background: Histamine intolerance manifests when there is an imbalance between the production of histamine and the body’s capacity to metabolise it. Within the gastrointestinal tract, diamine oxidase (DAO) plays a pivotal role in breaking down ingested histamine. Insufficient levels of DAO have been linked to various diseases affecting the respiratory, cardiovascular, nervous, muscular, and digestive systems; some of these symptoms are evidenced in fibromyalgia syndrome. This underscores the crucial role of DAO in maintaining the histamine balance and highlights its association with diverse physiological systems and health conditions. The management of fibromyalgia commonly involves the use of psychotropic medications; however, their potential interactions with DAO remain not fully elucidated. Methods: This study delved into the influence of various psychotropic medications on DAO activity through in vitro experiments. Additionally, we explored their impact on the human intestinal cell line Caco-2, examining alterations in DAO expression at both the mRNA and protein levels along with DAO activity. Results: Notably, the examined drugs—sertraline, pregabalin, paroxetine, alprazolam, and lorazepam—did not exhibit inhibitory effects on DAO activity or lead to reductions in DAO levels. In contrast, citalopram demonstrated a decrease in DAO activity in in vitro assays without influencing DAO levels and activity in human enterocytes. Conclusions: These findings imply that a collaborative approach involving psychotropic medications and DAO enzyme supplementation for individuals with fibromyalgia and a DAO deficiency could offer potential benefits for healthcare professionals in their routine clinical practice.

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Section: Introductionmentioning

confidence: 99%

Exploring the Relationship between Diamine Oxidase and Psychotropic Medications in Fibromyalgia Treatment, Finding No Reduction in Diamine Oxidase Levels and Activity except with Citalopram

Tobajas,

Alemany-Fornés,

Samarra

et al. 2024

JCM

View full text Add to dashboard Cite

show abstract

“…Although there is no definitive cure for HIT or DAO deficiency, individuals with these conditions can often manage their symptoms and enhance their quality of life through dietary adjustments and supplements like DAO enzymes [27]. Some pharmaceutical drugs, including proton pump inhibitors (PPIs) [28] and NSAIDs [29], have been reported to potentially inhibit DAO activity, which could lead to histamine-intolerance-related symptoms. Understanding these interactions is essential for patients with HIT who may be taking medications that affect DAO function.…”

Section: Introductionmentioning

confidence: 99%

Diamine Oxidase Interactions with Anti-Inflammatory and Anti-Migraine Medicines in the Treatment of Migraine

Tobajas,

Alemany-Fornés,

Samarra

et al. 2023

JCM

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Histamine intolerance arises when there is a disparity between the production of histamine and the body’s ability to break it down. In the gastrointestinal tract, the primary enzyme responsible for metabolizing ingested histamine is diamine oxidase (DAO), and a shortage of this enzyme has been associated with some diseases related to the respiratory, cardiovascular, nervous, muscular, and digestive systems, in addition to migraines. The treatment of migraines typically revolves around the utilization of both anti-migraine and anti-inflammatory drugs, but their interaction with DAO is not thoroughly understood. In this study, we examined the impact of nonsteroidal anti-inflammatory drugs (NSAIDs) and anti-migraine medications on DAO activity through in vitro experiments. We also investigated their effects on the human intestinal cell line Caco-2, assessing changes in DAO expression (both at the mRNA and protein levels) as well as DAO activity. The tested drugs, including ibuprofen, acetylsalicylic acid, paracetamol, a combination of acetylsalicylic acid with paracetamol and caffeine, zolmitriptan, and sumatriptan, did not inhibit DAO activity or reduce their levels. However, naproxen reduced DAO protein levels in human enterocyte cultures while not affecting DAO activity. These results suggest that combining anti-inflammatory and anti-migraine drugs with DAO enzyme supplementation for migraine patients with DAO deficiency could be beneficial for healthcare professionals in their daily practice.

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Proton Pumps: Molecular Mechanisms, Inhibitors and Activators of Proton Pumping

Abstract: Protein molecular machines, also known as proton pumps, are the most important element of biological membranes [...]

Cited by 2 publications

References 7 publications

Exploring the Relationship between Diamine Oxidase and Psychotropic Medications in Fibromyalgia Treatment, Finding No Reduction in Diamine Oxidase Levels and Activity except with Citalopram

Exploring the Relationship between Diamine Oxidase and Psychotropic Medications in Fibromyalgia Treatment, Finding No Reduction in Diamine Oxidase Levels and Activity except with Citalopram

Diamine Oxidase Interactions with Anti-Inflammatory and Anti-Migraine Medicines in the Treatment of Migraine

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