Proton radiation therapy for skull base chordomas and chondrosarcomas

Hug, Eugen B.; DeVries, Alexander; Laredo, Lilia N.; Slater, Jerry D.; Schaefer, Rosemary A.; Slater, James M.

doi:10.1016/s0959-8049(99)81485-3

Cited by 165 publications

(288 citation statements)

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“…Although some authors have reported an increase in tumor-free intervals after using radiotherapy for local control [26,32], others have reported radiotherapy has little influence on overall survival [8,9,28]. Two studies advocated the use of hadrons (ie, highdose protons or charged particles, such as carbon ions or helium) to improve the radiobiologic effect, mainly in cases of base of skull disease [17,23]. The physical and ballistic properties of hadrons allow delivery of higher doses to the target volume, while sparing organs at risk [7].…”

Section: Discussionmentioning

confidence: 99%

Sacral Chordoma: Can Local Recurrence After Sacrectomy Be Predicted?

Hanna¹,

Aston²,

Briggs³

et al. 2008

Clin Orthop Relat Res

109

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Surgical resection margins are reportedly the most important predictor of survival and local recurrence with sacral chordomas. We examined the relevance of invasion of the surrounding posterior pelvic musculature (piriformis and gluteus maximus) at initial diagnosis to local recurrence after sacrectomy. We retrospectively reviewed 18 patients with histologically verified sacral chordoma seen at our institution between 1998 and 2005. There were 14 men and four women with a mean age of 65.1 years (range, 31-78 years). The average overall followup was 4.4 years (range, 0.5-10 years), 5.4 years for the living patients (range, 3-10 years), and 2.8 years for the deceased (range, 0.5-5.4 years). Local recurrence occurred in 12 patients (66%) 29 months postoperatively (range, 2-84 months

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Section: Discussionmentioning

confidence: 99%

Sacral Chordoma: Can Local Recurrence After Sacrectomy Be Predicted?

Hanna¹,

Aston²,

Briggs³

et al. 2008

Clin Orthop Relat Res

109

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“…1 Bilateral loss of vision developing concurrently with radiographically proven tumour progression in the upper clivus has been described. 9 There has been no evidence of this in our patients.…”

Section: Discussionmentioning

confidence: 52%

Visual complications of proton beam therapy for clival chordoma

Bowyer

Natha

Marsh

et al. 2003

Eye

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Purpose Combining maximal surgical resection with high-dose proton radiation therapy is reported to be currently the best management of patients with clival chordoma. Method Since 1991, four consecutive patients from our institution with this tumour have been referred for postoperative proton beam radiotherapy.Result We have experienced an unusually high complication rate (50%) of delayed radiation optic neuropathy. This has resulted in profound, bilateral visual loss at 1 and 2 years postproton beam treatment. Conclusion It has served as a reminder that proton beam therapy is not an innocuous treatment option and this devastating complication should be taken into account when discussing the management of clivus chordoma. We postulate whether the optic apparatus is particularly sensitive to proton vs photon damage.

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“…[45][46][47][48]51,53 Pediatric CHs seem to fare better compared with their adult counterparts: 60-100% and 80-100%, respectively. 13,30,50,54,55 Nonetheless, younger children were frequently excluded in earlier series dealing with protons (since they require special attention, such as general anesthesia).…”

Section: Review Of Literaturementioning

confidence: 99%

“…45 This favorable outcome has been reproduced by multiple teams in US, Europe and Japan. [46][47][48] Doses were progressively upgraded to 75 Gy (EBR) (Gy (EBR) = physical dose × an estimated mean 1.1 RBE) and more, conventionally fractionated, at the price of an acceptable toxicity. Recently, carbon ions have also been advocated in place of protons.…”

Section: Review Of Literaturementioning

confidence: 99%

Reprint of “Chordoma in children: Case-report and review of literature”

Habrand

Datchary

Bolle

et al. 2016

Reports of Practical Oncology & Radiotherapy

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Sarcoma Protontherapy Children a b s t r a c tWe report an exceptional case of a very late local failure in a 9-year-old boy presenting with a chordoma of the cranio-cervical junction. The child was initially treated with a combination of surgical resection followed by high dose photon-proton radiation therapy. This aggressive therapy allowed a 9-year remission with minimal side-effects. Unfortunately, he subsequently presented with a local failure managed with a second full-dose course of protons. The child died one year later from local bleeding of unclear etiology.© 2015 Greater Poland Cancer Centre. Published by Elsevier Sp. z o.o. All rights reserved. IntroductionChordomas ( with the brachyury gene, a gene involved in the notochord development. 5,6 In the adults, they are located typically in the sacrococcygeal (SC) (50%), the intra cranial (IC), at the skull base (SB) (35%), and the intermediate spinal (S) regions (15%). Only 5% of cases have been described in the pediatric age, with unclear specificities concerning presentation, and outcome. We report in this paper a clinical case of skull base CH http://dx

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Proton radiation therapy for skull base chordomas and chondrosarcomas

Cited by 165 publications

References 0 publications

Sacral Chordoma: Can Local Recurrence After Sacrectomy Be Predicted?

Sacral Chordoma: Can Local Recurrence After Sacrectomy Be Predicted?

Visual complications of proton beam therapy for clival chordoma

Reprint of “Chordoma in children: Case-report and review of literature”

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