Proton therapy for uveal melanomas and other eye lesions

Munzenrider, John E.

doi:10.1007/bf03038893

Cited by 46 publications

(18 citation statements)

References 48 publications

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“…As of December 2002, over 3000 patients with uveal melanoma had been treated with protons at the MGH in collaboration with MEEI (Munzenrider, 1999). The 5-year actuarial local control rate Figure 1 Depth -dose distributions for a spread-out Bragg peak (SOBP, red), its constituent pristine Bragg peaks (blue), and a 10 MV photon beam (black).…”

Section: Ocular (Uveal) Melanomamentioning

confidence: 99%

Proton beam therapy

et al. 2005

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Conventional radiation therapy directs photons (X-rays) and electrons at tumours with the intent of eradicating the neoplastic tissue while preserving adjacent normal tissue. Radiation-induced damage to healthy tissue and second malignancies are always a concern, however, when administering radiation. Proton beam radiotherapy, one form of charged particle therapy, allows for excellent dose distributions, with the added benefit of no exit dose. These characteristics make this form of radiotherapy an excellent choice for the treatment of tumours located next to critical structures such as the spinal cord, eyes, and brain, as well as for paediatric malignancies.

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Section: Ocular (Uveal) Melanomamentioning

confidence: 99%

Proton beam therapy

et al. 2005

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“…A metal bead that was used to simulate a tumor can be clearly identified in the bottom right image secondary glaucoma. Other options are available along with the development of radiotherapy, including plaque brachytherapy [16,28], proton radiotherapy [23], transpupillary thermotherapy [24], and the promising stereotactic radiotherapy [2,18,21]. Taking the advantages of non-invasive treatment, Cyberknife radiosurgery has become an effective alternative for uveal melanoma.…”

Section: Discussionmentioning

confidence: 99%

A mechanical eyeball phantom for uveal melanoma radiosurgery by cyberknife

Chen

Hatoum

et al. 2014

J Radiat Oncol

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Objective A treatment option for uveal melanoma has been investigated using the Cyberknife system, due to its advantage of real-time image guidance during therapy. However, unpredictable eyeball movement imposes challenges to the state-ofart technology. As a solution, we derived a 2D/3D transformation algorithm that is based on the pupil's 2D coordinates captured by an optical tracking system to predict the tumor's 3D positions in real-time. In order to validate our developed algorithm and other methods, a mechanical phantom that can simulate the eyeball's movement is highly desirable. Methods We designed a mechanical phantom that consists of a camera module, an eyeball module with an embedded "tumor", an eyeball holder module, and an eyeball moving module. All materials are made with acrylic or nylon plastics with the exception of the linear motion stages and the camera. Results In the calibration procedure, the phantom is scanned using a CT scanner. By using the recorded pupil's coordinates and extracted tumor coordinates, the 2D/3D transformation model yields 0.39±0.09 mm root-sum-squared error for five calibration positions between the actual 3D coordinates and the predicted coordinates. In the validation procedure, the eyeball is rotated to 11 different positions through the mechanical phantom. The 2D/3D transformation model yields 0.58±0.27 mm root-sum-squared error for these positions between the Cyberknife-identified 3D coordinates and the predicted coordinates. The eyeball's position can be controlled within millimeter accuracy. Conclusion The designed mechanical phantom is suitable for validating image-guided radiosurgery methods. Further dynamic evaluations can confirm these methods for clinical applications.

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“…The Massachussets General Hospital/Harvard Cyclotron Laboratory (MGH/HCL) in Boston played a pioneering role, and 2568 uveal melanoma patients were treated through September 1998 [17].…”

Section: Uveal Melanomamentioning

confidence: 99%

Hadrons (protons, neutrons, heavy ions) in radiation therapy: rationale, achievements and expectations

Wambersie¹,

Gahbauer²

2001

Radiochimica Acta

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The safety, efficacy and reliability of photon beams is well established; however, new types of beams continue to be introduced and explored with the aim of achieving improved selectivity from better dose distribution or from radiobiological mechanisms. Fast neutrons were the first non-conventional radiation used in cancer therapy. Fast neutrons, a form of high-LET radiation, were introduced for the following radiobiological reasons: (1) a reduction of the OER with increasing LET, (2) a reduction in the difference in radiosensitivity related to the position of the cells in the mitotic cycle, (3) less repair and thus less clinical relevance of the different repair mechanisms. The best, clinically proven, indications for fast neutrons are salivary gland tumours, locally advanced prostatic adenocarcinomas and slowly growing, well differentiated sarcomas. Proton beams brought a significant improvement in the physical selectivity. Worldwide, the number of proton therapy centres in operation and in the planning stage increases continuously. The best clinical results so far have been reported for uveal melanoma, tumours of the base of skull, and some brain tumours in children. Heavy ions combine the advantage of better physical selectivity of protons with the radiobiological advantages of fast neutrons for some tumour types. Heavy ions were applied at Berkeley from 1975 to 1992, and at NIRS in Chiba since 1994. A pilot study started at GSI-Darmstadt in 1997. Boron neutron capture therapy (BNCT) aims at a physical selectivity at the cellular level; it is still in an experimental phase.

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Proton therapy for uveal melanomas and other eye lesions

Cited by 46 publications

References 48 publications

Proton beam therapy

Proton beam therapy

A mechanical eyeball phantom for uveal melanoma radiosurgery by cyberknife

Hadrons (protons, neutrons, heavy ions) in radiation therapy: rationale, achievements and expectations

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