Proton therapy is the most cost‐effective modality for partial breast irradiation

Ovalle, V.; DeWyngaert, J. Keith; Orton, Colin G.

doi:10.1118/1.4922709

Cited by 2 publications

(1 citation statement)

References 17 publications

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“…Several institutes have been reporting on the application of particle therapy for breast cancer; however, those reports concern proton therapy as part of postoperative adjuvant therapy [17–20]. To the best of our knowledge, the only articles on carbon ion radiotherapy for breast cancer in the literature are two case reports from NIRS [13, 21].…”

Section: Discussionmentioning

confidence: 99%

A Phase I clinical trial of carbon ion radiotherapy for Stage I breast cancer: clinical and pathological evaluation

Karasawa

Omatsu

Arakawa

et al. 2019

Journal of Radiation Research

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Even with its high RBE and >20 years history, there had been no breast cancer clinical trial using carbon-ion radiotherapy. We started a Phase I trial of carbon ion radiotherapy for Stage I breast cancer in 2013. This article describes the clinical and pathological evaluation of this study. Patients with low-risk Stage I breast cancer were eligible. A dose escalation study was designed, with dose levels of 48.0, 52.8 or 60.0 Gy relative biological effectiveness (RBE) administered in four fractions within 1 week. Three months after radiotherapy, the patients underwent tumor excision for pathological evaluation. Between April 2013 and December 2014, three cases receiving 48 Gy (RBE), three cases receiving 52.8 Gy (RBE) and one case receiving 60 Gy (RBE) underwent this protocol. No adverse effects were observed except for Grade 1 acute skin reaction in four cases. Pathological evaluation revealed that all four cases with doses of 52.8 Gy (RBE) and 60.0 Gy (RBE) achieved Grade 2b or more, but only two cases reached Grade 3. At the end of 2017, all cases were alive without recurrence or late had not caused any late adverse reaction. Carbon ion radiotherapy for Stage I breast cancer seems to be safe, and we found that it did not reach enough treatment effect 3 months after the treatment.

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