Protonenpumpenhemmer für den Intensivpatienten

Abstract

Stress-associated gastrointestinal mucosal lesions may complicate critical illness. Proton pump inhibitors (PPI) are the well-established therapeutic standard for acid-related mucosal injury. The role of PPI in preventing stress-associated mucosal damage is not completely clear yet. Although PPI are well tolerated, side effects such as increased infection risk, kidney injury, drug interactions, electrolyte disturbances or changes in microbiome composition have to be considered.