Proventriculitis in Broiler Chickens: Immunohistochemical Characterization of the Lymphocytes Infiltrating the Proventricular Glands

Pantin‐Jackwood, Mary J.; Brown, Thomas; Huff, G. R.

doi:10.1354/vp.41-6-641

Cited by 13 publications

(5 citation statements)

References 27 publications

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“…TVP, characterized by proventricular enlargement, ingesta retention in the lumen, and fragility of the gastric isthmus, has become a major issue worldwide in avian flocks since the 1970s ( 31 ). TVP was diagnosed according to the presence of clinical runting-stunting symptoms, gross lesions in the swollen proventriculi, histological lesions in the proventriculi, including necrotic oxynticopeptic cells, lymphocytic infiltration, glandular hyperplasia, and metaplasia ( Supplementary Figure 1 ).…”

Section: Resultsmentioning

confidence: 99%

Novel Cyclovirus Identified in Broiler Chickens With Transmissible Viral Proventriculitis in China

Yan

Zhou

et al. 2020

Front. Vet. Sci.

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In October 2018, an outbreak of transmissible viral proventriculitis (TVP) occurred in 30-day-old commercial broiler chickens on a farm in Weifang, China. TVP, an infectious viral disease characterized by runting and stunting, is associated with many viruses, and has a significant economic impact on the global poultry industry. TVP is diagnosed according to clinical symptoms, gross and histological lesions, and negative PCR results for pathogenic bacteria, avian leukosis virus subgroup J, Marek's disease virus, reticuloendotheliosis virus, infectious bursa disease virus, avian reovirus, chicken anemia virus, infectious bronchitis virus, chicken proventricular necrosis virus, gyrovirus 3 and chicken circovirus. To further detect the possible causative pathogens of TVP, we used PacBio third-generation sequencing to examine proventricular samples. A dominant abundance of the novel cyclovirus (CyCV), chCyCV-SDAU-1, was identified in broilers with TVP. The complete chCyCV-SDAU-1 genome was verified via inverse PCR, was 1936 bp long, and consisted of Rep, Cp, and two intergenic regions. Phylogenetic tree analysis showed that chCyCV-SDAU-1 formed an independent branch with other cycloviruses. The homology of chCyCV-SDAU-1 with 20 others known cycloviruses was < 40%. Retrospective investigation showed that the CyCV infection rate in the broilers with TVP was 80% (16/20), while no CyCV was found in healthy chickens. In conclusion, a novel CyCV was identified in chickens with TVP, though its role in this disease is unclear.

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Section: Resultsmentioning

confidence: 99%

Novel Cyclovirus Identified in Broiler Chickens With Transmissible Viral Proventriculitis in China

Yan

Zhou

et al. 2020

Front. Vet. Sci.

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“…Glandular and muscular gastritis is a transmissible disease that affects commercial chickens. It is characterized by the enlargement and ulceration of the glandular and muscular stomachs, poor feed conversion, poor uniformity, decreased body weight, and loose stools with undigested feed ( 5 ). The precise etiology of glandular and muscular gastritis remains unknown.…”

Section: Discussionmentioning

confidence: 99%

“…Several agents have been implicated as potential causes. Non-infectious causes include mycotoxins ( 4 ), biogenic amines ( 5 ), and high-level dietary copper ( 6 ). The infectious agents that have been implicated include clostridium infection ( 7 ), chicken proventricular necrosis virus infection ( 8 ), and infectious bursal disease virus infection ( 9 ).…”

Section: Introductionmentioning

confidence: 99%

Comparison of gut microbiota immunity and pathology in specific-pathogen-free chickens with glandular and muscular gastritis using different methods

Yan,

Yang,

Lin

et al. 2024

Front. Vet. Sci.

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The objective of this study is to review different methods to screen for the optimal model for preventing and treating chicken glandular and muscular gastritis syndrome. Twenty-four 40-day-old specific pathogen-free (SPF) chickens were randomly allocated into four groups (N = 6): polyethylene glycol + ammonium chloride group (M1 group), acetic acid + rhubarb group (M2 group), polyethylene glycol + rhubarb group (M3 group), and control group. The control group had free access to water, while the remaining groups received different doses of molding reagents added to their drinking water. The animal models were assessed based on clinical manifestations, histopathology findings, serological analysis, and composition of intestinal microbiota to establish an optimal approach for constructing an avian model of glandular and muscular gastritis. The SPF chickens in each model group exhibited typical symptoms of glandular and muscular gastritis, poor spirit, yellow loose stools with undigested feed, and enlargement and ulceration of the glandular and muscular stomach. Among these groups, the M3 group had the highest incidence rate of 100%. Compared to the control group, the body weight and body temperature of the chicken in the three model groups were reduced, and the glandular and muscular stomachs and duodenum showed different degrees of bleeding, mucosal abscission, and other pathological injuries. Additionally, the levels of serum IL-2 and α-amylase activity decreased while the content of IL-4 increased. After conducting 16s rDNA sequencing, it was observed that the abundance of Bacteroides, Faecalibacterium, and Ruminococcaceae UCG-014 was significantly increased in the model group compared to the control group. Conversely, there was a notable decrease in the levels of Megamonas and Lactobacillus, which are speculated to be associated with arachidonic acid metabolism, the NF-κB signaling pathway, and TNF signaling pathways. The combination of polyethylene glycol and rhubarb emerged as the most effective method for establishing the glandular and muscular gastritis model in SPF chickens. This constructed chicken model displayed distinct signs of damage to the glandular and muscular stomach, inflammatory response, and disturbance in the intestinal flora, thereby providing a foundation for future research on the prevention and treatment of this syndrome.

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“…Probably the Ensenadan Stage/Age was the period in the Pleistocene with a great number of mammals with ecological requirements of more open and arid environments [69]. The diversity of pampatheres during this Stage/Age is lower than that of the other cingulates, only two species of Pampatheriidae are recorded so far ( P .…”

Section: Discussionmentioning

confidence: 99%

A Peculiar New Pampatheriidae (Mammalia: Xenarthra: Cingulata) from the Pleistocene of Argentina and Comments on Pampatheriidae Diversity

et al. 2015

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Pampatheriidae are a group of cingulates native to South American that are known from the middle Miocene to the lower Holocene. Two genera have been recognized between the lower Pleistocene and the lower Holocene: Pampatherium Gervais and Ameghino (Ensenadan, Bonaerian and Lujanian, lower Pleistocene–lower Holocene) and Holmesina Simpson (Blancan, Irvingtonian, upper Pliocene–lower Holocene). They have been mainly differentiated by their osteoderm morphology and cranio-dental characters. These taxa had a wide latitudinal distribution, extending from the southern part of South America (Península Valdés, Argentina) to North America (Florida, USA). In this contribution, we describe a new genus and species of Pampatheriidae for the lower and middle Pleistocene of Buenos Aires Province and for the upper Pleistocene of Santa Fe Province (Argentina).The new taxon is represented by disarticulated osteoderms, one skull element, two thoracic vertebrae and a right femur and patella. It has extremely complex osteoderm ornamentations and particular morphological characters of the cranial element and femur that are not found in any other species of the family. This new taxon, recorded in the lower–middle Pleistocene (Ensenadan Stage/Age) and in the upper Pleistocene–early Holocene (Lujanian Stage/Age), is incorporated to the Pleistocene mammal assemblage of South America. Finally, the Pampatheriidae diversity is greater during the Lujanian Stage/Age than the Ensenadan Stage/Age.

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Proventriculitis in Broiler Chickens: Immunohistochemical Characterization of the Lymphocytes Infiltrating the Proventricular Glands

Cited by 13 publications

References 27 publications

Novel Cyclovirus Identified in Broiler Chickens With Transmissible Viral Proventriculitis in China

Novel Cyclovirus Identified in Broiler Chickens With Transmissible Viral Proventriculitis in China

Comparison of gut microbiota immunity and pathology in specific-pathogen-free chickens with glandular and muscular gastritis using different methods

A Peculiar New Pampatheriidae (Mammalia: Xenarthra: Cingulata) from the Pleistocene of Argentina and Comments on Pampatheriidae Diversity

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