“…Early in vitro findings suggest that bamlanivimab may e iciently neutralise the lineage B.1.1.7; however, no neutralising e ect could be detected against variant B.1.351 (Widera 2021). Use of mAb cocktails, a mixture of several mAbs and mAb fragments targeting di erent epitopes on the receptor-binding domain (RBD), may be more e icient in retaining the ability to neutralise SARS-CoV-2 and prevent the emergence of escape variants (Baum 2020a;Koenig 2021).…”
Section: How the Intervention Might Workmentioning
To assess the e ectiveness and safety of SARS-CoV-2-neutralising mAbs, including mAb fragments, to prevent infection with SARS-CoV-2 causing COVID-19; and to maintain the currency of the evidence, using a living systematic review approach.
“…Early in vitro findings suggest that bamlanivimab may e iciently neutralise the lineage B.1.1.7; however, no neutralising e ect could be detected against variant B.1.351 (Widera 2021). Use of mAb cocktails, a mixture of several mAbs and mAb fragments targeting di erent epitopes on the receptor-binding domain (RBD), may be more e icient in retaining the ability to neutralise SARS-CoV-2 and prevent the emergence of escape variants (Baum 2020a;Koenig 2021).…”
Section: How the Intervention Might Workmentioning
To assess the e ectiveness and safety of SARS-CoV-2-neutralising mAbs, including mAb fragments, to prevent infection with SARS-CoV-2 causing COVID-19; and to maintain the currency of the evidence, using a living systematic review approach.
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