Provisional Tic Disorder is not so transient

Kim, Soyoung; Greene, Deanna J.; Bihun, Emily C.; Koller, Jonathan M.; Hampton, Jacqueline M.; Acevedo, Haley; Reiersen, Angela M.; Schlaggar, Bradley L.; Black, Kevin J.

doi:10.1038/s41598-019-40133-4

Cited by 48 publications

(52 citation statements)

References 54 publications

(50 reference statements)

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“…Consistent with our previous report ( [3]; 20 participants overlapping), NewTics participants' tic symptoms improved on average between the baseline and follow-up sessions. The mean total tic score was 17.59 (SD = 6.10) at the baseline session and 13.78 (SD = 7.60) at the 12-month follow-up session.…”

Section: Mean Clinical Changesupporting

confidence: 91%

“…Provisional Tic Disorder (PTD) is diagnosed when tics have been present for less than a year. Tic symptoms may persist over one year but with variability in severity across individuals; while most children experience improvement in tic symptoms within the first few months, some children may show worsening of tic symptoms which can impair quality of life [3]. Better prognostic ability in PTD may lead to patient-specific treatment, with a focus on those who are at risk of tic symptom worsening.…”

Section: Introductionmentioning

confidence: 99%

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Hippocampal volume in Provisional Tic Disorder predicts tic severity at 12-month follow-up

Kim

Greene

D’Andrea

et al. 2020

Preprint

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Background: Previous studies have investigated the relationships between the volumes of subcortical structures (e.g. caudate, putamen, thalamus, amygdala, hippocampus) and present tic symptom severity or future tic outcome in individuals with Tourette syndrome (TS). The largest such study found increased hippocampal volume in children with TS, but studies in adolescents and adults found the opposite. Subcortical volumes have not been studied in children in their first year after tic onset.Objective: This study aimed to examine whether the volumes of subcortical structures measured shortly after tic onset can predict tic symptom severity at the one-year anniversary of tic onset, when TS can first be diagnosed. Methods:We obtained T1-weighted structural MRI scans from 40 children (24 with prospective motion correction [vNavs]) whose tics had begun less than 9 months (median 3.7 months) prior to the first study visit (baseline). We re-examined them at the 12-month anniversary of their first tic (follow-up), assessing tic severity using the YGTSS. We quantified the volumes of subcortical structures using volBrain software.Results: Hippocampal volume measured at the baseline visit correlated with tic outcome at the 12-month follow-up, with a larger hippocampus at baseline predicting worse tic outcome at follow-up. The volumes of other subcortical structures did not predict tic outcome at follow-up.Conclusion: These findings suggest that hippocampal volume may be an important marker in predicting prognosis in Provisional Tic Disorder.

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Section: Mean Clinical Changesupporting

confidence: 91%

Section: Introductionmentioning

confidence: 99%

Hippocampal volume in Provisional Tic Disorder predicts tic severity at 12-month follow-up

Kim

Greene

D’Andrea

et al. 2020

Preprint

Self Cite

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“…This study consisted of baseline and 12-month follow-up study visits. The baseline visit consisted of neuropsychological tests and clinical examination on one day (the full list of assessments has been reported in our previous work [ 3 ]) and an MRI scan visit (functional and structural MRI) within one week of the baseline visit. Clinical examination was repeated at a follow-up session 12-months after the best estimate date of the first definite tic.…”

Section: Methodsmentioning

confidence: 99%

“…While most children experience improvement in tic symptoms within the first few months after tic onset, some children continue to have tics for more than one year, meeting criteria for a Persistent (Chronic) Tic Disorder or Tourette’s Disorder (hereafter referred to as Tourette syndrome, “TS”). For children with persisting tics, severity can be quite variable across individuals, with some experiencing a significant worsening of tic symptoms that can impair quality of life [ 3 ]. Better prognostic ability in PTD may lead to patient-specific treatment, with treatment focused on those who are at greater risk of an increase in tic symptoms.…”

Section: Introductionmentioning

confidence: 99%

Hippocampal Volume in Provisional Tic Disorder Predicts Tic Severity at 12-Month Follow-up

Kim

Greene

D’Andrea

et al. 2020

JCM

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Previous studies have investigated differences in the volumes of subcortical structures (e.g., caudate nucleus, putamen, thalamus, amygdala, and hippocampus) between individuals with and without Tourette syndrome (TS), as well as the relationships between these volumes and tic symptom severity. These volumes may also predict clinical outcome in Provisional Tic Disorder (PTD), but that hypothesis has never been tested. This study aimed to examine whether the volumes of subcortical structures measured shortly after tic onset can predict tic symptom severity at one-year post-tic onset, when TS can first be diagnosed. We obtained T1-weighted structural MRI scans from 41 children with PTD (25 with prospective motion correction (vNavs)) whose tics had begun less than 9 months (mean 4.04 months) prior to the first study visit (baseline). We re-examined them at the 12-month anniversary of their first tic (follow-up), assessing tic severity using the Yale Global Tic Severity Scale. We quantified the volumes of subcortical structures using volBrain software. Baseline hippocampal volume was correlated with tic severity at the 12-month follow-up, with a larger hippocampus at baseline predicting worse tic severity at follow-up. The volumes of other subcortical structures did not significantly predict tic severity at follow-up. Hippocampal volume may be an important marker in predicting prognosis in Provisional Tic Disorder.

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“…Children with other neurodevelopmental or psychiatric comorbidities or learning disabilities were excluded. The mean Yale Global Tic Severity Scale (YGTSS) total tic score (TTS) was 20.7±6.4 (range: 8-33) [5,54] in the whole patient group. Two participants showed minimal tic severity (TTS � 10); 17 showed mild tic severity (score [11][12][13][14][15][16][17][18][19][20]; and 19 showed moderate to severe tic severity (score > 20).…”

Section: Participantsmentioning

confidence: 99%

Impairment of visually guided associative learning in children with Tourette syndrome

Eördegh¹,

Pertich²,

Tárnok³

et al. 2020

PLoS ONE

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The major symptoms of Tourette syndrome are motor and vocal tics, but Tourette syndrome is occasionally associated with cognitive alterations as well. Although Tourette syndrome does not affect the majority of cognitive functions, some of them improve. There is scarce evidence on the impairment of learning functions in patients with Tourette syndrome. The core symptoms of Tourette syndrome are related to dysfunction of the basal ganglia and the frontostriatal loops. Acquired equivalence learning is a kind of associative learning that is related to the basal ganglia and the hippocampi. The modified Rutgers Acquired Equivalence Test was used in the present study to observe the associative learning function of patients with Tourette syndrome. The cognitive learning task can be divided into two main phases: the acquisition and test phases. The latter is further divided into two parts: retrieval and generalization. The acquisition phase of the associative learning test, which mainly depends on the function of the basal ganglia, was affected in the entire patient group, which included patients with Tourette syndrome with attention deficit hyperactivity disorder, obsessive compulsive disorder, autism spectrum disorder, or no comorbidities. Patients with Tourette syndrome performed worse in building associations. However, the retrieval and generalization parts of the test phase, which primarily depend on the function of the hippocampus, were not worsened by Tourette syndrome.

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Provisional Tic Disorder is not so transient

Cited by 48 publications

References 54 publications

Hippocampal volume in Provisional Tic Disorder predicts tic severity at 12-month follow-up

Hippocampal volume in Provisional Tic Disorder predicts tic severity at 12-month follow-up

Hippocampal Volume in Provisional Tic Disorder Predicts Tic Severity at 12-Month Follow-up

Impairment of visually guided associative learning in children with Tourette syndrome

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