Proximal femoral focal deficiency (PFFD) is a rare and sporadic congenital anomaly. The femoral dysplasia may range from hypoplastic femur to the severe form of femoral agenesis. Only few cases have been reported in Africa, and none in Cameroon before now. We hereby report two cases of PFFD, among which one is an unusual case of femoral agenesis. The were no identifiable risk factors for this anomaly in the maternal and family histories. Definitive treatment of this anomaly is complex, challenging, multidisciplinary, and somewhat difficult to carryout in limited resource facilities.