Background: Keinböck's disease (KD) is an uncommon medical condition characterized by avascular necrosis of the lunate. Conservative treatment of this condition consists of immobilization, strengthening and range of motion (ROM) exercises of the surrounding musculature of the wrist. Tissue flossing is a relatively new treatment technique that incorporates wrapping latex bands around the targeted body part, followed by a brief period of exercise. Tissue flossing is thought to provide similar therapeutic effects to blood reperfusion and/or blood flow restriction therapy. Purpose: Present a clinical case detailing the use of flossing bands in the treatment of a collegiate men's basketball player suffering from KD of the right wrist. Treatment: A 21-year old basketball player reported to the athletic training clinic complaining of worsening wrist pain and stiffness. The patient had attempted conservative treatment with little relief. Following evaluation with magnetic resonance imaging, the patient was diagnosed with KD. At this time, the use of tissue flossing to attempt to restore pain free ROM and to potentially increase blood flow began. After two weeks of treatment, the patient's symptoms and reported function had improved. The patient continued treatment and rehabilitation program until the beginning of his competitive season, at which point he began a maintenance program. Uniqueness: The KD diagnosis would increase likelihood of surgical intervention later on. However, in this case, the patient was able to return to full function without surgical intervention to date. We are unaware of any case report describing the use of tissue flossing bands as an adjunct treatment for KD. Conclusion: Tissue flossing bands may be a viable therapeutic procedure for symptoms such as pain and/or decreased ROM. Further studies need to be conducted in order to determine the potential therapeutic application and methodology of tissue following bands.