“…Importantly, notice that a cMPR was used in our study for the manual analysis, which already tends to present a lower IOV compared to the more traditional double-oblique reconstruction technique (which additionally requires manual alignment and reconstruction of the AoA plane directly in the 3D MDCT image). 22 Such a result emphasizes the increased reproducibility obtained when using the proposed automated framework, in which the user only identifies two points and the software automatically segments and identifies the AoA plane. In the case of a fully automatic analysis, no interaction is required at all, therefore eliminating any userinduced variability.…”