2004
DOI: 10.1124/jpet.104.079475
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Proximal Tubular Toxicity of Ochratoxin A Is Amplified by Simultaneous Inhibition of the Extracellular Signal-Regulated Kinases 1/2

Abstract: Ochratoxin A (OTA) is a mycotoxin involved in the development of chronic nephropathies and a known carcinogen. As we have shown previously, OTA activates mitogen-activated protein kinases [extracellular signal-regulated kinase 1 and 2 (ERK1/2), c-jun amino-terminal kinase (JNK), and extracellular-regulated protein kinase 38 (p38)] in proximal tubular cells (opossum kidney and normal rat kidney epithelial). ERK1/2, JNK, or p38 are thought to mediate opposite action on apoptosis, fibrosis, and inflammation. As w… Show more

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Cited by 36 publications
(15 citation statements)
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“…7). The MAPK phosphorylation level remained constant over the next 3 hr; these results are in concordance with those of previous studies and confirm the time-dependent OTA activation of these three MAPKs (Sauvant et al, 2005).…”
Section: Discussionsupporting
confidence: 82%
“…7). The MAPK phosphorylation level remained constant over the next 3 hr; these results are in concordance with those of previous studies and confirm the time-dependent OTA activation of these three MAPKs (Sauvant et al, 2005).…”
Section: Discussionsupporting
confidence: 82%
“…, extracellular signal-regulated kinase 1 and 2 (ERK1/2)), c-jun amino-terminal kinase (JNK), and extracellular-regulated protein kinase 38 (p38) in proximal tubular cells [41,42]. In our paper, we have examined the role of pRaf/MEK1/2 and p38 in OTA-mediated TNF-α release in comparison with LPS.…”
Section: Resultsmentioning
confidence: 99%
“…Cidofovir Human tubules/HK-2 [144] Cisplatin Mouse PTC [71,171,180] Mouse CDC [181] Cyclosporine A MDCK [182] Rat: subcortical and juxtamedullary kidney sections [179] Tubular and interstitial cells [ Endotoxins Human tubular epithelial cells [185,186] Mice (Fas-/-, TNFR1-/-TNFR2-/-) [187] C3H/HeJ Mice [188] Fluoroquinolones Human: distal tubular cells [189] Mercuric chloride Cultured rat proximal tubular cells (WKPT) [178] LLC-PK1 [190] Microcystin Rat: kidney cortex and medulla [191] Ochratoxin A PRK [192] OK [193] NRK-52E [193] Oxalate MDCK [194] Radio-contrast agents MDCK [195][196][197] LLC-PK1 [197,198] …”
Section: Intrinsic Pathwaymentioning
confidence: 99%