Proximalisation of Colorectal Carcinoma: A 10-year Study in Italy

Fenoglio, Luigi; Cena, Paola; Bracco, Christian; Pomero, Fulvio; Migliore, Elena; Benedetti, Valentina; Morino, Mario; Perin, Paolo Cavallo

doi:10.1007/s10620-007-9916-z

Cited by 3 publications

(7 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Granulation tissue can be prominent, particularly in the cap polyps (Cheng, 2009), and a vascular component is a key finding in the angiogenic polypoid proliferations. Additionally, distortion of the muscularis mucosa might obliterate the usual histological landmarks of mucosa and submucosa (Fenoglio et al, 2008). The surface of these polyps might be covered by a membrane of mucinous and inflammatory exudates, providing a picture similar to that of ischemic colitis.…”

Section: Discussionmentioning

confidence: 99%

MMP9 is protective against lethal inflammatory mass lesions in the mouse colon

Hald

Rønø

Melander

et al. 2011

Disease Models &Amp; Mechanisms

View full text Add to dashboard Cite

SUMMARYThe family of matrix metalloproteinases (MMPs) is responsible for extracellular matrix degradation during physiological and pathophysiological tissue remodeling processes such as embryogenesis, tissue repair and cancer progression. Despite these important roles of MMPs, inhibition or ablation of individual members of the MMP family in animal models have been shown to have little effect. It has been speculated that this results from a functional overlap between individual MMPs and (as-yet-unclassified) functional overlaps between MMPs and other protease systems. We here present genetic data showing that concomitant ablation of MMP9 (gelatinase B) and the serine protease plasmin results in lethal inflammatory mass lesions in the colon. These lesions possessed several histological attributes that are characteristic of mucosal prolapse seen in humans, and they were found to be associated with splenomegaly, enlarged mesenteric lymph nodes, decreased thymus size and altered populations of circulating immune cells. A time-course study provided evidence that the massive lymphoid hyperplasia and reactive changes were secondary to discrete fibrinous lesions also observed in mice only deficient for plasminogen (Plg), the zymogen for plasmin. These data demonstrate a non-appreciated vital protective role for MMP9 in the absence of Plg.

show abstract

Section: Discussionmentioning

confidence: 99%

MMP9 is protective against lethal inflammatory mass lesions in the mouse colon

Hald

Rønø

Melander

et al. 2011

Disease Models &Amp; Mechanisms

View full text Add to dashboard Cite

show abstract

“…By increasing the incidence of proximal carcinomas, it seems evident that only FS may not be considered the gold standard as a screening method while total colonoscopy might be the method of choice for CRC screening in subjects at an intermediate risk [34]. To date, in Italy, four epidemiological studies have been performed in order to highlight likely variations in the anatomic distribution of this neoplasm [19,23,35,36] with contrasting results. In a twenty year study (1978-1999) performed in Northern Italy [19], a significant increase both in the incidence of CRCs and proximal lesions was observed, more markedly in the female gender over age 70 years.…”

Section: Discussionmentioning

confidence: 99%

“…In contrast to the previous two studies, the study published in 2004 [36] and carried out between 1984-1998, showed no significant changes in the CRC distribution, but rather an increase in the incidence of the lesions in all the colon segments, attributed by the authors to the age of the general population. In 2008, a retrospective study [35] was carried out on Turin population between 1992-2001; results showed a reduced prevalence (from 9.9% to 6.8%) with no evidence of proximalization. On the contrary, an increased number of both diagnosed lesions and proximal shifts as regards polyps was found.…”

Section: Discussionmentioning

confidence: 99%

A shift from distal to proximal neoplasia in the colon: a decade of polyps and CRC in Italy

et al. 2010

Self Cite

View full text Add to dashboard Cite

show abstract

“…Several studies, mainly in the United States, have revealed a proximal shift of CRC during the past few decades, 11,12,14,43 whereas other Western reports have demonstrated no alteration in the anatomic distribution of CRC. 15,16,40 Surprisingly, recent studies in Asia have indicated that there was a rightward shift of CRC in several Asian countries, especially in Japan. 21,42 However, other studies have not found a trend towards an increased prevalence of RSCC.…”

Section: Discussionmentioning

confidence: 99%

“…increasing quite noticeably, [10][11][12][13][14] although other Western studies do not support this finding. [15][16][17] However, relevant studies are limited in Eastern populations. A few studies in Asia have suggested a proximal shift in CRC, [18][19][20][21] whereas other Eastern scientists stated that no shift was found.…”

mentioning

confidence: 99%

Reevaluation of a rightward shift in colorectal cancer: A single‐center retrospective study in Tianjin

Chen

Liu

et al. 2019

J of Digest Diseases

View full text Add to dashboard Cite

Objectives Some Western reports have shown a proximal shift in colorectal cancer (CRC), but there are few studies in China. This study aimed to provide more information for the management and screening of CRC by investigating trends in the anatomic distribution of CRC among the Chinese population in recent years. Methods A retrospective study was conducted on patients with CRC admitted to the Digestive Endoscopy Center of Tianjin Medical University General Hospital between January 2000 and December 2017. Patients were divided into a left‐sided colorectal cancer (LSCRC) group and a right‐sided colon cancer (RSCC) group. The detection rates of LSCRC and RSCC based on patients' age and sex, and on the time periods were analyzed. Results A total of 2319 cases were diagnosed with CRC among 75 183 consecutive patients. The prevalence of CRC showed a significant reduction from 2000‐2008 to 2009‐2017 (3.8% vs 2.7%, P < .001). The proportion of RSCC presented a downtrend from 2000‐2008 to 2009‐2017 (40.6% vs 37.7%, P > .05). There were slightly more RSCCs in female patients than in male patients, with no significant difference (40.9% vs 36.5%, P > .05). The proportion of RSCC in patients aged ≥50 years was similar to that in younger patients. The alarming symptoms between LSCRC and RSCC showed a significant difference (P < .05). Conclusions In the present study, the prevalence of CRC declined significantly with time. However, there did not appear to be a rightward shift in CRC among the patients in Tianjin over the past 18 years.

show abstract

Proximalisation of Colorectal Carcinoma: A 10-year Study in Italy

Abstract: We can suppose that proximalisation of carcinoma has not yet appeared in Italy.

Cited by 3 publications

References 28 publications

MMP9 is protective against lethal inflammatory mass lesions in the mouse colon

MMP9 is protective against lethal inflammatory mass lesions in the mouse colon

A shift from distal to proximal neoplasia in the colon: a decade of polyps and CRC in Italy

Reevaluation of a rightward shift in colorectal cancer: A single‐center retrospective study in Tianjin

Contact Info

Product

Resources

About